Heterocycles with Nitrogen (N)

<p>Applications 5-Amino-4H-1,2,4-triazole-3-carboxylic Acid is a building block used in the synthesis of purine nucleotide analogs by a promiscuous hypoxanthine phosphoribosyltransferase.<br>References Scism, R.A., et. al.: Org. Lett., 9, 4179 (2007)<br></p>

<p>Applications 2-Benzoylpyrrole (cas# 7697-46-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(1-Adamantyl)-4,5-dihydro-1H-imidazole (cas# 52725-79-8) is a useful research chemical.<br></p>

<p>Applications 6-Chloro-3-Fluoro-2-Iodopyridine (cas# 1211590-36-1) is a useful research chemical.<br></p>

<p>Applications Methyl 5-Oxopyrrolidine-3-carboxylate has been used as a reactant in the synthesis of tert-butyloxycarbonyl protected 4,5-methano-β-proline.<br>References Tymtsunik, A.V., et. al.: Tetrahedron Lett., 55, 3312 (2014)<br></p>

<p>Applications Bimodal effect of the picolinic acid derivatives on the rate of wheat and pea germination.<br>References Hamaker, J., et al.: Science, 141, 363 (1963),<br></p>

<p>Applications 1-(2-Chlorophenyl)-3-phenyl-4-(m-tolyl)-6,8-dihydro-1H-pyrazolo[3,4-e][1,4]thiazepin-7(4H)-one is an intermediate for the synthesis of 1-(2-Chlorophenyl)-1,4,6,7-tetrahydro-4-(3-methylphenyl)-7-oxo-3-phenyl-8H-pyrazolo[3,4-e][1,4]thiazepine-8-acetic Acid (C597045).<br></p>

<p>Applications 1-Acetyl-1H-pyrazole-4-boronic acid, pinacol ester<br></p>

<p>Applications 6-Methoxy-4-pyrimidinamine is used in the synthesis of carbamothiolacrylamides as selective EP2 antagonists in the treatment of neurodegenerative peripheral diseases. Also used in the preparation of PARP-1 inhibitors.<br>References Ganesh, T. et al.: ACS Med. Chem. Lett., 4, 616 (2013); Rhee, H. et al.: Bioorg, Med. Chem., 17, 7537 (2009);<br></p>

<p>Applications 3-Piperidinesulfonic Acid is an isomer of piperidine-4-sulfonic acid, a new specific GABA agonist.<br>References Krogsgaard-Larsen, P., et al.: J. Neurochem., 34, 756 (1980)<br></p>

<p>Applications Pyridine-15N, is the labeled analogue of Pyridine (P991280), a basic six-membered heterocyclic ring. Pyridine is a base structure present in many biologically active compounds like the vitamins niacin and pyridoxal. Pyridine is used in dehalogenation reactions and can be used as a base in condensation reactions.<br>References Egyed, J. et al.: Bull. Soc. Chim. Fra., 11, 3014 (1973); Li, Y. et al.: Wuli HUa. Xueb., 14, 1048 (1998);<br></p>

<p>Applications Phenyl (4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamate Hydrochloride is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.<br>References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);<br></p>

<p>Applications 2,5-Diacetamido-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one (cas# 22365-29-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Bromo-N-[4-bromo-2-(2-pyridinylcarbonyl)phenyl]-acetamide is a derivative of 2-(2-Amino-5-bromobenzoyl)pyridine (A601785); an intermediate in the preparation of Bromazepam (B678500).<br>References Panderi, I., et al.: J. Pharm. Biomed. Anal., 17, 327 (1998); El-Haj, B., et al.: J. Anal. Toxicol., 25, 316 (2001); Hansen, S., et al.: J. Pharm. Biomed. Anal., 39, 322 (2005)<br></p>

<p>Applications 3-chloropyridazine hydrochloride (cas# 856847-77-3) is a useful research chemical.<br></p>

<p>Applications Benzimidazole-4,5,6,7-d4 (CAS# 64531-29-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Imidazole rings are found in numberous natural compounds such as enzymes, nucleic acid, and alkaloids that play a role in biological processes.<br></p>

<p>Applications 4-Amino-2,6-dichloropyridine (cas# 2587-02-2) is a compound useful in organic synthesis.<br>References Altenbach, R., et al.: J. Med. Chem., 51, 6571 (2008), Namba, K., et al.: Bioorg. Med. Chem., 16, 6131 (2008),<br></p>

<p>Applications α-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-4-hydroxybenzeneacetic acid is used in the preparation of Cefoperazone an antibiotic.<br>References Xu, Y., et al.: Zhongguo Yaoke Daxue Xuebao, 28, 264 (1997);<br></p>

<p>Applications 2-Hydrazino-1H-1,3-benzimidazole<br></p>

<p>Applications N-(3-{[2-chloro-5-(trifluoromethyl)pyrimidin-4-yl]amino}phenyl)prop-2-enamide (cas# 1374507-25-1) is a useful research chemical.<br></p>

<p>Applications 5-Bromo-6-chloropyridine-3-sulfonyl Chloride (cas# 216394-05-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinol, can be used for the synthesis of a novel series of [3.2.1] azabicyclic biaryl ethers as α3β4 and α6/4β4 nicotinic receptor agonists.<br>References Lowe, J. A., et al.: Bioorg. Med. Chem. Lett., 20, 4749 (2010);<br></p>

<p>Applications 4-(chloromethyl)-3,5-dimethyl-1H-pyrazole (cas# 152239-41-3) is a useful research chemical.<br></p>

<p>Applications N-BOC-Piperidin-4-ylmethyleneboronic acid pinacol ester is a useful research chemical.<br></p>

<p>Applications 6-Methyl-2,3'-bipyridine (cas# 78210-78-3) is a useful research chemical.<br></p>

<p>Applications 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile (cas# 33097-13-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Hydroxypyridine, is a building block used in various chemical synthesis. It is used for the synthesis of bicyclic pyridinol analogues acting as antioxidants and capable of preserving mitochondrial function.<br>References Xiaoqing, X. C., et al.: Bioorg. Med. Chem., 20 (11), 3584 (2012);<br></p>

<p>Applications (4-Chlorobenzo[b]thiophen-2-yl)(piperazin-1-yl)methanone is a useful research chemical.<br></p>

<p>Applications 1,1’-Thiocarbonyldiimidazole can be used to deoxygenate carboxylic monosaccharide analogues.<br>References Loke, I., et al.: Tetrahedron, 68, 697 (2012),<br></p>

<p>Applications Pyridine-2,6-d2 (CAS# 17265-96-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-[4-(3-Pyrrolidinyl)1,3-thiazol-2yl]guanidine is a reagent which is used in biological studies as antiulcer agent.<br>References Gupta, S., et al.: J. Chem. Info. Comp. Sci, 39, 272 (1999)<br></p>

<p>Applications 4,6-Dimethyl-2-(methylthio)pyrimidine is a useful reactant for the synthesis of substituted heterocycles via nickel-catalyzed cross-coupling reaction.<br>References Melzig, L., et al.: J. Org. Chem., 75, 2131-33 (2010);<br></p>

<p>Applications 6-Bromopicolinic acid<br></p>

<p>Applications 2-(3-Aminophenyl)-1H-benzo[d]imidazol-6-amine (cas# 13676-49-8) is a useful research chemical.<br></p>

<p>Applications 5-(Trifluoromethyl)-1H-pyrazole-4-carboxylic acid (cas# 543739-84-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-​Hydrazinyl-​4-​methylbenzoxazole is a useful research chemical.<br></p>

<p>Applications 6-Bromo-2-fluoropyridin-3-ol (cas# 850142-72-2) is a useful research chemical.<br></p>

<p>Applications N-3-Piperidinylcarbamic Acid 1,1-Dimethylethyl Ester is used in the synthesis of highly selective spleen tyrosine kinase inhibitors. Also used in the synthesis of a potent NHE1 inhibitor displaying cardioprotective effects.<br>References Lucas, M. et al.: J. Med. Chem., 55, 10414 (2012); Huber, J. et al.: J. Med. Chem., 55, 7114 (2012);<br></p>

<p>Applications Methyl 5-Hydroxy-2-benzimidazolecarbamate-d3, is a labeled analogue of Methyl 5-Hydroxy-2-benzimidazolecarbamate (M312585), which is a derivative of Carbendazim (C175900).<br>References Zeng, Z., et al.: J. Agric. Food Chem., 44, 3374 (1996), Lewis, D., et al.: Xenobiotica, 28, 235 (1998), Hodgson, E., et al.: J. Biochem. Mol. Toxicol., 21, 182 (2007),<br></p>

<p>Applications 1-isobutyl-1H-pyrazole-3-carboxylic acid (cas# 1006493-64-6) is a useful research chemical.<br></p>

<p>Applications 7-Bromo-5-(pyridin-2-yl)-1H-benzo[e][1,4]diazepine-2(3H)-thione is used in the preparation of triazolobenzodiazepines with antianxiety and antidepressant activity.<br>References Hester, J.B., et. al.: J. Med. Chem., 23, 392 (1980)<br></p>

<p>Applications 6-Desamino-6-oxo Phenazopyridine is a Phenazopyridine (P313751) degradation product/impurity, and is a useful synthetic intermediate.<br>References Nickerson, B., et al.: J. Liq. Chromatogr., 18, 3947 (1995)<br></p>

<p>Applications [1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine (cas# 3176-50-9) is a useful research chemical.<br></p>

<p>Applications (R)-3-Aminopiperidine-2-one<br></p>

<p>Applications 3-Bromopropionic Acid N-Hydroxysuccinimide (cas# 101314-84-5) is a compound useful in organic synthesis.<br></p>

<p>Applications {2-[(Pyridin-4-ylmethyl)thio]-1,3-thiazol-4-yl}acetic acid (cas# 1040631-48-8) is a useful research chemical.<br></p>

<p>Applications 2-Fluoropyridine-5-carbonyl chloride<br></p>

<p>Applications N-[1-[1-(4-Methoxyphenyl)-1H-tetrazol-5-yl]-1-methylpropyl]-1H-indole-3-ethanamine,<br></p>

<p>Applications 2,4-Dichloro-5-bromopyrimidine (cas# 36082-50-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,6-di-tert-Butylpyridine is used in the preparation of polymers with n-type nitroxide side groups to be used in organic radical batteries.<br>References Jaehnert, T., et. al.: Eur. Polymer J., 61, 105 (2014)<br></p>

<p>Applications N-Boc-3-(1-cyano-2-ethoxy-2-oxoethylidene)-1-piperidine is a useful synthetic intermediate.<br></p>

<p>Applications 2-(5-Ethylpyridin-2-yl)prop-2-en-1-ol is a key intermediate in the synthesis of pioglitazone hydrochloride.<br>References Mohanty, S., et al.: Org. Process Res. Dev., 18, 168 (2014)<br></p>

<p>Applications 2,2,6,6-Tetramethylpiperidine-1,4-diol is related to 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy (H956500), which is a free radical scavenger. 2,2,6,6-Tetramethylpiperidine-1,4-diol has also been shown to be an in vitro and in vivo radioprotector. It is used as a reagent in stereoselective preparation of tetrasubstituted triarylated olefins via Pd-catalyzed sequential oxidative Heck arylation of alkenes with arylboronic acids using nitroxides as oxidants.<br>References Flather, M., et al.: Lancet, 355, 1575 (2000); Sasso, F., et al.: Metabolism, 52, 675 (2003); Kass, D., et al.: Circ. Res., 94, 1533 (2004); Murdoch, C., et al.: Cardiovasc Res., 71, 208 (2006); Hahn, M., et al.: Free Radic. Biol. Med., 28, 953 (2000); He, Z., et al.: Angew. Chem. Int. Ed., 51, 3699 (2012);<br></p>

<p>Applications N-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-carboxamide hydrochloride (cas# 1219957-27-3) is a useful research chemical.<br></p>

<p>Applications Methyl 6-Amino-3,5-dibromopyridine-2-carboxylate is used as a reagent in the synthesis of imidazopyridines as Syk inhibitors. Also used as a reagent in the synthesis of quinoline, quinoxaline and naphthyridine derivatives as antibacterial agents.<br>References Blomgren, P., et al.: PCT Int. Appl. WO 2011112995 A1 20110915. Sep 15, 2011; Daines, R.A., et al.: PCT Int. Appl. WO 2007016610 A2 20070208. Feb 8, 2007<br></p>

<p>Applications 3-Amino-5-ethyl-5-phenylimidazolidine-2,4-dione (cas# 1139-11-3) could be useful for biological studies. An anticonvulsant.<br>References Lange, J., et al.: Pol. (1982), PL 123138 B1<br></p>

<p>Applications 6,7-Dihydro-Imidazo[1,5-a]pyrazin-8(5H)-one is a useful research chemical.<br></p>

<p>Applications 1,2-Benzisoxazole has therapeutic uses. It could be useful for treating parkinsonism.<br>References Panza, F., et al.: Expert Opin. Pharmacother., (2020)<br></p>