Heterocycles with Nitrogen (N)

<p>Applications 2-Hydrazino-1H-1,3-benzimidazole<br></p>

<p>Applications α-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-4-hydroxybenzeneacetic acid is used in the preparation of Cefoperazone an antibiotic.<br>References Xu, Y., et al.: Zhongguo Yaoke Daxue Xuebao, 28, 264 (1997);<br></p>

<p>Applications (3E)-4-(5-Ethoxy-3-pyridinyl)-3-buten-1-ol is an intermediate in the synthesis of TC 2559 Fumarate (T012005), which is a partial agonist for AChR α4β2.<br></p>

<p>Applications Benzimidazole-4,5,6,7-d4 (CAS# 64531-29-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Bromo-N-[4-bromo-2-(2-pyridinylcarbonyl)phenyl]-acetamide is a derivative of 2-(2-Amino-5-bromobenzoyl)pyridine (A601785); an intermediate in the preparation of Bromazepam (B678500).<br>References Panderi, I., et al.: J. Pharm. Biomed. Anal., 17, 327 (1998); El-Haj, B., et al.: J. Anal. Toxicol., 25, 316 (2001); Hansen, S., et al.: J. Pharm. Biomed. Anal., 39, 322 (2005)<br></p>

<p>Applications (S)-3-Aminopiperidin-2-one-D6 is a labelled analogue of (S)-3-Aminopiperidin-2-one (A627940). (S)-3-Aminopiperidin-2-one, is an building block , used in the synthesis of various pharmaceutical compounds. It is an intermediate in the synthesis of calpinactam derivatives, possessing antimycobacterial activity.<br>References Kenichiro, N., et al.: Bioorg. Med. Chem. Lett., 22, 7739 (2012);<br></p>

<p>Applications Phenyl (4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamate Hydrochloride is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.<br>References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);<br></p>

<p>Applications Pyridine-15N, is the labeled analogue of Pyridine (P991280), a basic six-membered heterocyclic ring. Pyridine is a base structure present in many biologically active compounds like the vitamins niacin and pyridoxal. Pyridine is used in dehalogenation reactions and can be used as a base in condensation reactions.<br>References Egyed, J. et al.: Bull. Soc. Chim. Fra., 11, 3014 (1973); Li, Y. et al.: Wuli HUa. Xueb., 14, 1048 (1998);<br></p>

<p>Applications 5-phenyl-1H-1,2,3-triazole-4-carboxylic acid (cas# 830-78-4) is a useful research chemical.<br></p>

<p>Applications Methyl 5-Oxopyrrolidine-3-carboxylate has been used as a reactant in the synthesis of tert-butyloxycarbonyl protected 4,5-methano-β-proline.<br>References Tymtsunik, A.V., et. al.: Tetrahedron Lett., 55, 3312 (2014)<br></p>

<p>Applications 6-Chloro-3-Fluoro-2-Iodopyridine (cas# 1211590-36-1) is a useful research chemical.<br></p>

<p>Applications 2-(1-Adamantyl)-4,5-dihydro-1H-imidazole (cas# 52725-79-8) is a useful research chemical.<br></p>

<p>Applications 2-Benzoylpyrrole (cas# 7697-46-3) is a compound useful in organic synthesis.<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications 5-(4-Bromo-2-methylphenyl)-1H-tetrazole (cas# 1007128-19-9) is a useful research chemical.<br></p>

<p>Applications Isotope labelled 1-Ethyl-5-hydroxy-2-pyrrolidinone (E919175), an important organic solvent used in varnishing. Industrial solvent.<br>References Koch, H. et al. Arch. Toxicol., 88, 893 (2014); Koslitz, S. et al.: Toxicol. Lett., 231, 142 (2014);<br></p>

<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Used in the synthesis of peptides. Contains up to 10% imidazole.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pierschbacher, M., et al.: Nature, 309, 30 (1984),<br></p>

<p>Applications 4-Benzyloxazolidine-2,5-dione (cas# 583-47-1) is a useful research chemical.<br></p>

<p>Applications 5-fluoro-4-hydrazino-2-methoxypyrimidine (cas# 166524-64-7) is a useful research chemical.<br></p>

<p>Applications 4-Ethyl-1,3-Oxazolidin-2-One (cas# 16112-60-0) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 6-Methylpyridine-3-boronic Acid Hydrochloride Hydrate is the Hydrochloride of M326565, which is used in the preparation of various biologically active compound such as phosphoinositide-3-kinases (PI3K) and c-jun N-terminal kinase (JNK) inhibitors.<br>References Smith, A.L. et al.: J. Med. Chem., 55, 5188 (2012); Perry, B. et al.: Bioorg. Med. Chem. Lett., 18, 4700 (2008); Chambers, J. et al.: ACS Chem. Neurosci., 2, 198 (2011);<br></p>

<p>Applications 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one is used to prepare pyridino[2,3-d]pyrimidin-7(8H)-one derivatives as CDK4 and/or CDK6 inhibitors useful in the treatment of diseases.<br>References Li, X., et al.: PCT Int. Appl., WO 2014183520 A1 20141120 (2014)<br></p>

<p>Applications (7H-Pyrazolo[3,4-b]pyridin-5-yl)methanamine Hydrochloride is a useful research chemical.<br></p>

<p>Applications 2-Chloro-5-nitropyrimidin-4-ol is an intermediate used in the synthesis of 4-Chloro-5-nitro-2-(propylthio)pyrimidine (C374095), which is an impurity of the drug Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Applications 1-(Trimethylsilyl)-1H-benzotriazole (cas# 43183-36-4) is a useful research chemical.<br></p>

<p>Applications 5-Methyl-2(1H)-pyridinone-d6 is a reagent used in the preparation of substituted N-aryl pyridinones as fibrotic inhibitors.<br></p>

<p>Applications 5-(2-Pyridyl)isoxazole-3-carboxylic Acid is a useful reagent for the preparation of isoxazoles for treatment of neurological disease.<br>References Wrona, I., et al.: PCT Int. Appl. (2019), WO 2019209962 A1<br></p>

<p>Applications Oxazolidine-4-carboxylic acid hydrochloride (cas# 162285-30-5) is a useful research chemical.<br></p>

<p>Applications 2-Amino-4-chloro-3-nitropyridine (cas# 6980-08-1) is a compound useful in organic synthesis.<br>References Bavetsias, V., et al.: Bioorg. Med. Chem. Lett., 17, 6567 (2007), Niculescu-Duvaz, D., et al.: J. Med. Chem., 52, 2255 (2009),<br></p>

<p>Applications 1,2-benzisoxazol-3-amine (cas# 36216-80-5) is a useful research chemical.<br></p>

<p>Applications 5-Chloro-2,3-difluoropyridine is a 2,3,5-trihalopyridine used in the preparation of the herbicides and pesticides such as chodinafop-propargyl.<br>References Chen, Q. et al.: Jin. Huag. Zhong., 35, 35 (2005); Feng, C. et al.: Nonyao, 46, 793 (2007);<br></p>

<p>Applications 3-tert-Butylthio-2-cyanopyridine (cas# 178811-40-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 3,5-Dimethylpyrazole-4-boronic acid, Hydrochloride is a useful research chemical for organic synthesis and other chemical processes.<br>References Jones, A., et al.: From PCT Int. Appl. (2016), WO 2016046530 A1 20160331<br></p>

<p>Applications α-Butyl-α-(2,4-dichlorophenyl)-4H-1,2,4-triazole-4-ethanol is a useful synthetic intermediate.<br></p>

<p>Applications N-(2-(2-Nitro-1H-imidazol-1-yl)ethyl)acrylamide is a useful synthesis intermediate.<br></p>

<p>Applications 3-Bromopicolinic Acid Sodium Salt (cas# 1189933-55-8) is a compound useful in organic synthesis.<br>References See mercaptopicolinic acid file<br></p>

<p>Applications 3-(1H-Tetrazol-5-yl)benzoic Acid is a useful reactant in organic synthesis.<br>References Ouellette, Wayne, et al.: Inorganica Chimica Acta, 391, 36-43 (2012);Ramachandran, Sreekanth A., et al.: Bioorg. &amp; Med. Chem. Let., 27(10), 2153-2160 (2017)<br></p>

<p>Applications 5-Amino-1-phenylpyrazole is a reagent that is used in the synthesis of sulfaphenazole(S689020) derivatives as inhibitors and tools for comparing active sites of human liver cytochromes P 450 2C subfamily.<br>References Vestergren, A.L.S. et al.: Mol. Biol. Rep., 39, 6867 (2012); Huang, C. et al.: Amer. J. Phys., 298, H570 (2010); Ha-Douong, N., et al.: J. Med. Chem., 44, 3622 (2001);<br></p>

<p>Stability Hygroscopic<br>Applications 2-(2-Aminobenzoyl)pyridine, is an intermediate used for the synthesis of various Quinoline derivatives. It can also be used in the synthesis of the antitumoral agent batracylin and related isoindolo[1,2-b]quinazolin-12(10H)-ones.<br>References Chia-Chung, Ch., et al.: Organic Reactions, 28 (1982); Martinez-Viturro, C. M., et al.: Tetrahedron Letters, 48, 1023 (2007);<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-Oxyl-2,2,5,5-tetramethyl-∆3-(methanesulfonyloxymethyl)pyrroline is an intermediate in the synthesis of 3-Iodomethyl-(1-oxy-2,2,5,5-tetramethylpyrroline)-15N the isotope labelled analog of 3-Iodomethyl-(1-oxy-2,2,5,5-tetramethylpyrroline) (I709500); a thio-reactive spin label.<br>References Qin, P.Z., et al.: Biochemistry, 40, 6929 (2001);<br></p>

<p>Stability Light Sensitive, Moisture Sensitive<br>Applications (1-Oxyl-2,2,5,5-tetramethyl-4-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-3-yl)methyl Methanesulfonate is an intermediate in the synthesis of highly active spin labelling reagents.<br></p>

<p>Applications 2-​Amino-​5-​(trifluoromethyl)​ is a reagent used in the synthesis of selective inhibitors of urokinase plasminogen activator in a non-cytotoxic form of cancer therapy.<br>References Gladysz, R. et al.: J. Med. Chem., 58, 9238 (2015);<br></p>

<p>Applications (2,3-Dimethylpyridin-4-yl)boronic Acid is used to prepare substituted azaanthracene derivatives as GLP-1 receptor modulators useful in the treatment of GLP-1 receptor-mediated diseases<br>References Mjalli, A., et al.: PCT Int. Appl. (2010), WO 2010114824 A1 20101007<br></p>

<p>Applications 2-Oxo-2-(1-phenyl-1H-pyrazol-4-yl)acetic Acid is a derivative of N-Phenylpyrazole, a reactant in the synthesis of candesartan cilexetil(C175580), an ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive.<br>References Seki, M. et. al: ACS Catalysis, 4, 4047 (2014); Shibouta, Y., et al.: J. Pharmacol. Exp. Ther., 266, 114 (1993; Ogihara, T., et al.: Clin. Ther., 16, 74 (1994)<br></p>