Heterocycles with Nitrogen (N)

<p>Applications Pioglitazone (P471000) intermediate.<br>References Kletzien, R., et al.: Mol. Pharmacol., 41, 393 (1992),<br></p>

<p>Applications 3-(2,5-dimethyl-1H-pyrrol-1-yl)-2-thiophenecarboxylic Acid (cas# 477888-48-5) is a useful research chemical.<br></p>

<p>Applications 5-acetyl-6-hydroxy-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (cas# 58713-03-4) is a useful research chemical.<br></p>

<p>Applications 5-Amino-1,3-diphenyl-1H-pyrazole is a reagent for the preparation of molecular switches within GIRK activator scaffold that afford selective GIRK inhibitors.<br>References Wen, W., et al.: Bioorg. Med. Chem. Lett., 23, 4562 (2013); Karschin, C., et al.: J. Neurosci., 16, 3559 (1996)<br></p>

<p>Applications 6-Amino-5-(4-bromophenyl)-4(3H)-pyrimidinone is a degradation product of Macitentan (M105005).<br>References Thummar, Mohit, et al.: Chromatographia, 81(3), 525-531 (2018)<br></p>

<p>Applications 2,4-difluoro-5-{5H,6H,7H,8H,9H-[1,2,4]triazolo[4,3-a]azepin-3-yl}aniline (cas# 941166-01-4) is a useful research chemical.<br></p>

<p>Applications 4-Amino-2,2,6,6-tetramethylpiperidine-d17-1-oxyl (CAS# 70588-04-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-(chloromethyl)-2-(4-nitrophenyl)-1,3-oxazole (cas# 39867-96-4) is a useful research chemical.<br></p>

<p>Applications 4-{3H-Imidazo[4,5-c]pyridin-2-yl}aniline is derived from 3,4-Diaminopyridine (D415950), which is used as a reagent in the preparation of 9-deazaxanthine derivatives which had activity as dual antagonists/MAO-B inhibitors with potential as anti-Parkinson’s agent.<br>References Rivara, S., et al.: J. Med. Chem., 56, 1247 (2013)<br></p>

<p>Applications [4-[(4-Methylpiperazin-1-yl)methyl]phenyl]boronic Acid is used to prepare N-(3-(pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamides as B-Raf kinase inhibitors.<br>References Berger, D., et al.: Bioorg. Med. Chem. Lett., 19, 6519 (2009)<br></p>

<p>Applications (4R)-2,2-Dimethyl-4-[(1S)-1-[(phenylmethyl)amino]-2-propen-1-yl]-3-oxazolidinecarboxylic Acid 1,1-Dimethylethyl Ester is a useful synthetic intermediate.<br></p>

<p>Applications 5-Chloro 7-Deschloropiperaquine is an impurity of Piperaquine (P480050); a 4-aminoquinoline derivative used as an antimalarial agent.<br>References Nguyen, T.M.T., et al.: Tap Chi Duoc Hoc, 57, 22 (2007); Song, J., et al.: Malaria J., 10, 231 (2011); Lindegardh, N., et al.: J. Chromatogr. A, 1135(2), 166-169 (2006)<br></p>

<p>Applications A new reagent that is a naphtalene analog of 4-(4'-N,N-Dimethylaminophenyl)urazole (D451750).<br>References Shams, E., et al.: Analitical Sci., 2002, 18, 993 ;<br></p>

<p>Applications 2-Aminopyrazine-5-carboxylic Acid Methyl Ester (cas# 13924-94-2) is a compound useful in organic synthesis.<br></p>

<p>Applications B-[2-(Methylamino)-4-pyridinyl]boronic Acid Hydrochlroide, is used to prepare novel selective thiazoleacetic acids as CRTH2 antagonists.<br>References Grimstrup, M., et al.: Bioorg. Med. Chem. Lett., 20, 1181 (2010)<br></p>

<p>Applications 3-Bromo-1-(triisopropylsilyl)pyrrole<br></p>

<p>Applications 2-(p-Tolyl)pyridine (cas# 4467-06-5) is a useful research chemical.<br></p>

<p>Applications 2-(1H-Imidazol-1-yl)acetonitrile is a reactant that has been used in the synthesis of lanoconazole (L174500), an antifungal.<br>References Chen, Y., et. al.: Jiingxi Huagong Zhongjianti, 39, 28 (2009); Oka, H., et al.: Arzneim.-Forsch., 42, 345 (1992); Niwano, Y., et al.: Antimicrob. Agents Chemother., 38, 2204 (1994); Munt, L.: et al.: Oyo Yakuri, 43, 195 (1992)<br></p>

<p>Stability Hygroscopic<br>Applications (4R,6R)-4-(2-Carboxyethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-4,6-dicarboxylic Acid, is an isomer of Mikimopine (M385508), which forms in roots after transformation with agrobacterium and influences alkaloid production. This in turn affects insect toxicity and allelopathic properties.<br>References Sauerwein, M. et al.: J. Plant Physiol., 142, 446 (1993);<br></p>

<p>Applications N-Acetylpiperazine-d4 is labelled N-Acetylpiperazine-d4 which was used to prepare (aryl)sulfanyltriazoles with HIV-1 non-nucleoside reverse transcriptase inhibiting activities. It was also used to synthesize diphenylpyrazolecarboxamides as heat shock protein chaperone inhibitors and anticancer agents.<br>References Wang, Z., et al.: Bioorg. Med. Chem. Lett., 16, 4174 (2006); Brough, P., et al.: J. Med. Chem, 51, 196 (2008)<br></p>

<p>Applications 6-Amino-2-(4-aminophenyl)benzoxazole (cas# 16363-53-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Formyl-2-methylpyrimidine (cas# 90905-33-2) is a compound useful in organic synthesis.<br></p>

<p>Applications (2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid (cas# 4113-97-7) is a useful research chemical.<br></p>

<p>Applications Pyridine-4-d1 (CAS# 10259-15-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-(5-formylpyrimidin-2-yl)glycine (cas# 915923-65-8) is a useful research chemical.<br></p>

<p>Applications (4S)​- 5,​5-​Dimethyl-​2-​[[[(5-​methyl-​3-​phenyl-​4-​isoxazolyl)​carbonyl]​amino]​methyl]​-4-​thiazolidinecarboxyl​ic acid is a useful reactant.<br></p>

<p>Applications 1-Pyridin-2-yl-propan-2-one is an antimicrobial bioactive compound extracted from Lactarius vellereus fermenting liquor.<br>References Ji, H., et al.: Beijing Linye Daxue Xuebao, 30, 92 (2008); Song, R., et al.: From Faming Zhuanli Shenqing (2008), CN 101230368 A 20080730;<br></p>

<p>Stability Hygroscopic<br>Applications Methyl 4-Oxopiperidine-3-carboxylate Hydrochloride (cas# 71486-53-8) is a useful research chemical.<br></p>

<p>Applications 4-Amino-2,6-dichloro-3-nitropyridine (cas# 2897-43-0) is a compound useful in organic synthesis.<br>References Palmer, A., et al.: Bioorg. Med. Chem., 16, 1511 (2008),<br></p>

<p>Applications Intermediate of Zonisamide-N-(6-hexanoic acid).<br></p>

<p>Applications 2,6-Piperazinedione Hydrochloride is a synthetic intermediate that can be used to prepare anti-inflammatory or antitumor compounds. 2,6-Piperazinedione Hydrochloride is also applicable for the synthesis of 4-succinamoyl-piperazine-2,6-dione derivatives, which are compounds with analgesic properties.<br>References Shvedaite, I. P., et al.: Pharmaceut Chem J 33, 313 (1999); Shvedaite, I. P. and Shimkyavichene, V. I.: Pharmaceut Chem J  33, 359 (1999); Svedaite, I.: Chemija 18, 50 (2007)<br></p>

<p>Applications trans-4-Fluoropyrrolidine-2-carboxylic Acid-13C1 Hydrochloride Salt is an isotopic analog of (2S,4R)-4-Fluoropyrrolidine-2-carboxylic Acid (F594640).<br></p>

<p>Applications 1-(pyrimidin-4-yl)piperidine-4-carboxylic acid hydrochloride (cas# 179051-38-8) is a useful research chemical.<br></p>

<p>Applications 1-(p-Toluenesulfonyl)imidazole 99% (cas# 2232-08-8) is a useful research chemical.<br></p>

<p>Applications 1-(2-bromophenyl)piperazine (cas# 1011-13-8) is a useful research chemical.<br></p>

<p>Applications 3-(2,5-Dioxo-2,5-Dihydro-1h-Pyrrol-1-yl)benzoic Acid (cas# 17057-07-7) is a useful research chemical.<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications 2,2'-Bipyridine-4,4'-dicarboxylic acid<br></p>

<p>Applications 5-Cyano-1-methylbenzoimidazole<br></p>

<p>Applications 1H-1,2,4-Triazole-3-carboxylic acid, 1-ethyl-, methyl ester (cas# 1034197-43-7) is a useful research chemical.<br></p>

<p>Applications 4-BROMO-2-PYRIDINECARBOXAMIDE (cas# 62150-46-3) is a useful research chemical.<br></p>

<p>Applications (R)-Benzyl 2-((5-bromo-1H-indol-3-yl)methyl)pyrrolidine-1-carboxylate is used in the preparation of indole-derivative serotoninergic receptor agonists.<br></p>

<p>Applications Guanine (G836000) analog.<br>References Kini, G., et al.: J. Med. Chem., 34, 3006 (1991),<br></p>

<p>Applications 5-Methoxyoxazole-2-carboxylic Acid Methyl Ester,is a oxazole-containing compound, that can be extensively used in medicinal chemistry. The oxazole group is a key element of a number of biologically active natural products.<br>References Thalhammer, A., et al.: Tetrahedron Lett., 50, 1045 (2009);<br></p>

<p>Applications 2,3-Diamino-4-chloropyridine<br></p>

<p>Applications 5-Hydroxy-3H-imidazole-4-carboxamide (cas# 56973-26-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Pyrrole-d5 (CAS# 18430-85-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications tert-Butyl 2-cyanopiperazine-1-carboxylate (cas# 1053656-76-0) is a useful research chemical.<br></p>

<p>Stability Light Sensitive, Moisture Sensitive, Temperature Sensitive<br>Applications 7,9-Dimethoxycarbonyl-2-ethoxycarbonyl-1H-pyrrolo-[2,3-f]quinoline-4,5-dione (cas# 80721-47-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(4-aminophenoxy)-N,N-dimethylpyridine-2-carboxamide (cas# 284462-86-8) is a useful research chemical.<br></p>

<p>Applications 4-Piperidinemethanol, is a building block that can be used for the synthesis of selective inhibitors of sphingosine kinase 1 (SK1), that may serve as therapeutic agents for proliferative diseases, including hypertension.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baek, D., et al.: Chem.l Commun., 49, 2136 (2013);<br></p>