Heterocycles with Nitrogen (N)

Applications (2-oxo-4-phenylpyrrolidin-1-yl)acetic Acid (cas# 67118-34-7) is a useful research chemical.

Applications 2-Amino-4-hydroxy-6-chloro-s-triazine is an aromatic intermediate compound useful for the preparation of substituted melamine, ammelides, and ammelines.
References Hapeman, C., et al.: J. Agric. Food Chem., 43, 1383 (1995), Garcia-Montano, J., et al.: Environ. Sci. Technol., 42, 6663 (2008),

Applications 6-amino-5-chloro-2-cyclopropylpyrimidine-4-carboxylic Acid (cas# 858956-08-8) is a useful research chemical.

Applications Used as a reagent for the synthesis of acridine (A190900) derivatives and fibrinogen receptor antagonists.
References Yang, D. et al.: Macromol., 35, 5304 (2002); Harrison, R.J. et al.: Bioorg. Med. Chem. Lett., 9, 2463 (1999);

Impurity Minoxidil EP Impurity B
Applications 6-Chloro-pyrimidine-2,4-diamine (cas# 156-83-2) is a compound useful in organic synthesis.

Applications 2,5,6-Triaminopyrimidin-4(1H)-one sulphate (cas# 39267-74-8) is a useful research chemical.

Applications 1,2-DIMETHYLIMIDAZOLE (cas# 1739-84-0) is a useful research chemical.

Applications 1,2-Bis(4-(benzo[d]oxazol-2-yl)phenyl)ethene (cas# 1533-45-5) is a useful research chemical.

Applications 2,2,6,6-Tetramethyl-1-hydroxypiperidine is a reactant used in various synthesis and investigations. It was used as a reactant in the study of predicting organic hydrogen atom transfer rate constants using the Marcus cross relation. 2,2,6,6-Tetramethyl-1-hydroxypiperidine was also used as a reactant in the preparation of ammonia from an iron nitrido complex.
References Scepaniak, J., et al.: Angew. Chem. Int. Ed., 48, 3158 (2009); Warren, J., Mayer, J.: Proc. Natl. Acad. Sci. U.S.A., 107, 5282 (2010);

Applications 3-(Methoxycarbonyl)pyridine-5-boronic acid, pinacol ester

Applications A useful starting material for Clindamycin analyogues, such as Pirlimycin.
References Birkenmeyer, R.D., et al.: J. Med. Chem., 27, 2, 216 (1984)

Applications An intemediate of Clopidogrel and Prasugrel.
References Yadav, G., et al.: Biochem. Eng. J., 19, 101(2004), Wang, P., et al.: Enzyme Microb. Technol., 39, 930 (2006),

Applications 2,2':6',2''-Terpyridine (cas# 1148-79-4) is a useful research chemical.

Applications 2-Bromopyridine is a 2-halogenated pyridine used in the preparation of a variety of biologically active compounds such as antimalarial agents and beta-adrenoceptor agonist.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References LaMontagne, M.P. et al.: J. Med. Chem., 17, 519 (1974); Yoshizaki, S. et al.: Chem. Pharm. Bull., 37, 3430 (1989);

Applications Oxazolidine Cabazitaxel is an impurity of Cabazitaxel (C046500) which is a novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer.
References Agarwal, N. et al.: Fut. Oncol., 7, 15 (2011); Mita, A. et al.: Clin. Cancer Res., 15, 723 (2009); Figg, W.D. et al.: Cancer Biol. Ther., 10, 1233 (2010);

Applications 3-Chloro-6-phenylpyridazine (cas# 20375-65-9) is a useful research chemical.

Applications 2-Phenyl-1H-benzimidazole is a reagent used in the synthesis of various aryl-substituted benzimidazole derivatives. Also used in the synthesis of benzimidazole and quinocaline derivatives
References Saleh, V. et al.: Org. Chem. Int., 1, (2015); Hasanpour, M. et al.: J. Chin. CHem. Soc., 62, 412 (2015);

Applications 4-(2-cyclopropyl-1,3-oxazol-5-yl)aniline (cas# 1031130-92-3) is a useful research chemical.

Applications Piperonylic Acid is a compound closely mimicking the structure of transcinnamic acid involved in the phenylpropanoid pathway in plant physiology.
References Schalk, M. et al.: Plant Physiol., 118, 209 (1998);

Applications α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol is used as a reagent in the synthesis of Medetomidine (M203250); an α2-adrenergic agonist. Also a sedative and analgesic.
References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996); Chen, W., et al.: Faming Zhuanli Shenqing. CN 101921234 A 20101222. Dec 22, 2010

Applications 3-Amino-5-mercapto-1,2,4-triazole is used as a corrosion inhibitor. It can also be used as a reactant in the synthesis of triazole derivatives.
References Ergun, Umit, et al.: J. of Mat. Eng. and Perf., 23(1), 213-221 (2014); Elgemeie, Galal H., et al.: Nucleosides, Nucleotides & Nucleic Acids, 37(2), 112-123 (2018)

Applications N-Methylsuccinimide-d3 is the isotope labelled analog of N-Methylsuccinimide (M329425); a model compound used to investigate the mechanism of enolization step by density-functional theory (DFT) calculations. N-Methylsuccinimide is a metabolite of N-methyl-2-pyrrolidone (NMP) and its presence in plasma and urine can be used as a biomarker of exposure to NMP
References Takahashi, O., et al.: Chem. Biodivers., 7, 1349 (2010)

Applications Urazole (cas# 3232-84-6) is a useful research chemical.

Applications 2-Aminopyridine (D6, 98%) (cas# 203784-57-0) is a useful research chemical.

Applications 1-BUTYLPYRROLIDIN-2-ONE (cas# 3470-98-2) is a useful research chemical.

Applications 2-Hydrazino-1,3-benzoxazole

Applications 6-Hydroxy 2,4,5-Triaminopyrimidine Sulfate (cas# 1603-02-7) is a compound useful in organic synthesis.

Applications methyl 1-(2,4-difluorophenyl)-3-phenyl-1H-pyrazole-5-carboxylate (cas# 1202030-37-2) is a useful research chemical.

Applications 1,5,8,12-Tetrakis[4,6-bis(N-butyl-N-1,2,2,6,6-pentamethyl-4-piperidylamino)-1,3,5-triazin-2-yl]-1,5,8,12-tetraazadodecane is used as a light/thermal stabilizer in olefin polymers intended for use in contact with food.
References Kohler, D.R. et al.: Polym. Degrad. Stab., 63, 165 (1998); The Food and Drug Administration: Fed. Reg., 65, 16314 (2000);

Applications 5-(4-Chlorobutyl)-1-cyclohexyltetrazole-d11 (cas# 1073608-19-1) is a compound useful in organic synthesis.

Impurity Rabeprazole EP Impurity F
Applications An antidegradant, protecting rubber from oxidation. An intermediate in the synthesis of Rabeprazole (R070500)
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Beheshti, A., et al.: J. Food Sci., 75, C135 (2010), Rohrig, U., et al.: J. Med. Chem., 53, 1172 (2010),

Applications 2,4,6-Tris[bis(methoxymethyl)amino]-1,3,5-triazine (cas# 3089-11-0) is a useful research chemical.

Applications (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate used to prepare dipeptidyl peptidase IV (DPP-IV) inhibitors.
References Yoshida, T., et al.: Bioorg. Med. Chem., 20, 5705 (2012); Sakashita, H., et al.: Bioorg. Med. Chem., 15, 641 (2007)

Applications 1-(1-phenylpropan-2-yl)-1H-pyrrole-2-carboxylic acid (cas# 1432680-68-6) is a useful research chemical.

Stability Volatile
Applications 2,4,6-Tris(trifluoromethyl)-1,3,5-triazine is used as a secondary battery electrolyte in power storage systems.
References Hiasa, T., et al.: Jpn. Kokai Tokkyo Koho, 77 (2018)

Applications N,N'-Di-4-pyridinyl-methanediamine is used to prepare bis(heteroaryl)-imidazolidinediones with oxalyl chloride.
References Ghandi, M., et al.: Synth. Comm., 37, 637 (2007)

Applications N-(chloroacetoxy)succinimide is a N-hydroxysuccinimide ester of a simple carboxylic acid. N-(chloroacetoxy)succinimide is used in the preparation of organometallic complexes and other synthetic probes for the labeling of proteins.
References Salmain, M. et al.: Bioconj. Chem., 4, 425 (1993); Nonaka, H. et al.: J. AM. Chem. Soc., 129, 15777 (2007);

Applications 5-Aminomethyl-2-chloropyridine is a reagent that is used in the synthesis of macamides and analogs that have FAAH (fatty acid amide hydrolase) inhibitory activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wu, H., et al.: Bioorg. Med. Chem., 21, 5188 (2013);

Applications 3-Aminopiperidine-2,6-dione hydrochloride is a reagent for preparing lenalidomide that can induce ubiquitination and degradation of CK1α in del(5q) MDS. It can also be used to prepare phthalimide conjugates that can promote ligand-dependent target protein degradation.
References Kronke, J., et al.: Nature 523, 183 (2015); Liu C., et al.: Faming Zhuanli Shenqing CN 105348257 A 20160224 (2016); Rao, R., et al. : PCT Int. Appl. WO 2016024286 A2 20160218 (2016)

Applications (4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone is used in the synthesis of Ezetimibe (E975000), an antihyperlipoproteinemic; a cholesterol absorption inhibitor.
References Bankowski, K., et. al.: Przemysl Chemiczny, 91, 289 (2012); van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)

Applications 5-Benzylthio-1H-tetrazole is used in the preparation of organosilicon compounds that have antibacterial activity.
References Baghershiroudi, Mahrokh. et al., J. IRAN. CHEM. SOC. 15,1279-1286(2018);

Applications Vardenafil oxopiperazine-D6 is a labelled analogue of Vardenafil oxopiperazine (V098030)

Applications Orotic Acid Monosodium Salt is used in the formation of a complex with lanthanium(III) which displats cytotoxic activity on different tumor cell lines.Also, it is the unlabeled form of Orotic Acid-15N2 Monosodium Salt (O691517), which is an intermediate used in the synthesis of Orotic Acid-15N2 Monohydrate (O691504), which is a labeled analogue of Orotic Acid Monohydrade (O691500), which is used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment.
References Kostova, I., et al.: Int. J. Curr. Chem., 1, 271-280 (2010)

Stability Moisture Sensitive
Applications N-Methyl-1H-imidazole-1-carboxamide is a useful Methyl Isocyanate (MIC) substitute.

Applications 5-phenyl-1,3-oxazolidin-2-one (cas# 7693-77-8) is a useful research chemical.

Applications Methyl 2-Oxo-1-pyrrolidineacetate is used a reagent in the synthesis of benzoquinolizidine and benzoindolizidine derivatives as anti-amnesic agents. It is also used as a a reagent in the synthesis of (acylamino)acridines as choline uptake enhancers.
References Zhao, S., et al.: Bioorg. Med. Chem., 7, 1637 (1999); Chaki, H., et al.: Bioorg. Med. Chem. Lett., 5, 1489 (1995)

Applications 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is used in preparation and structure of alkaline earth iodide phosphine oxide and urea complexes as reactant or reagents.
References Fitts, Lacey S., et al.: New J. of Chem., (2016); Hall, Jessica E., et al.: Angew. Chem. Int. Ed., 55, 11153-11157 (2016)