Heterocycles with Nitrogen (N)

Applications (αR)-α-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-4-hydroxy-benzeneacetic Acid is an intermediate used to prepare Cephalosporin derivatives with activities against both Gram-positive and Gram-negative bacteria.
References Albrecht, H., et al.: J. Med. Chem., 37, 400 (1994)

Applications 2-(1h-1,2,4-Triazol-1-Yl)Acetic Acid (cas# 28711-29-7) is a useful research chemical.

Applications 5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol (cas# 172152-53-3) is a useful research chemical.

Stability Hygroscopic
Applications 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is used as a reagent in the synthesis of N-(2-acylaminobenzyl or 2-acylaminoheterocyclylmethyl)thiophene-2-carboxamide derivatives as antithrombotics. It is also used as a reagent in the synthesis of diamide derivatives as FXa inhibitors. 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is an intermediate for Edoxaban (E555520).
References Mochizuki, A., et al.: Jpn. Kokai Tokkyo Koho. JP 2010120852 A 20100603. Jun 3, 2010; Mochizuki, A., et al.: PCT Int. Appl. WO 2008123017 A1 20081016. Oct 16, 2008

Applications Hydrocinnamic Acid N-Hydroxysuccinimide Ester (cas# 109318-10-7) is a compound useful in organic synthesis.

Applications Pyridin-3-yl dimethylcarbamate (cas# 51581-32-9) is a useful research chemical.

Applications α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol is used as a reagent in the synthesis of Medetomidine (M203250); an α2-adrenergic agonist. Also a sedative and analgesic.
References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996); Chen, W., et al.: Faming Zhuanli Shenqing. CN 101921234 A 20101222. Dec 22, 2010

Applications Piperonylic Acid is a compound closely mimicking the structure of transcinnamic acid involved in the phenylpropanoid pathway in plant physiology.
References Schalk, M. et al.: Plant Physiol., 118, 209 (1998);

Applications N-Methylsuccinimide is used as a model compound to investigate the mechanism of enolization step by density-functional theory (DFT) calculations. N-Methylsuccinimide is a metabolite of N-methyl-2-pyrrolidone (NMP) and its presence in plasma and urine can be used as a biomarker of exposure to NMP
References Takahashi, O., et al.: Chem. Biodivers., 7, 1349 (2010)

Applications Ethyl (5-Ethyl-2-pyridinyl)acetate (cas# 99986-02-4) is a compound useful in organic synthesis.

Applications The most characteristic degrdadation product of melanins. An important biomarker for Melatonin (M215000) metabolism.
References Shen, X., et al.: J. Med. Chem., 39, 2018 (1996), Xin, W., et a: Chem. Res. Toxicol., 13, 749 (2000), An, L., et al.: Food Chem. Toxicol., 44, 436 (2006),

Applications 2-Hydrazino-1,3-benzoxazole

Applications 1,3,5-trimethyl-1H-pyrazole-4-carboxylic acid (cas# 1125-29-7) is a useful research chemical.

Applications 2-[(p-chlorobenzyl)amino]-pyridine is a useful synthetic intermediate. It can be prepared via selective iridium-catalyzed alkylation of (hetero)aromatic amines.
References Blank, B., et al.: Chem. Eur. J., 15, 3790 (2009); Liu, C., et al.: J. Org. Chem., 76, 5759 (2011)

Impurity Esomeprazol EP Impurity A/ Omeprazole EP Impurity A
Applications 5-Methoxy-2-mercaptobenzimidazole (Esomeprazol EP Impurity A) is used in the synthesis of COX-2 inhibitors
References Frechette, S., et al.: Bioorg. Med. Chem. Lett., 18, 1502 (2008), Zhang, R., et al.: Eur. J. Med. Chem., 44, 3771 (2009),

Applications 3,4-Dimethylpyrazole (cas# 2820-37-3) is a compound useful in organic synthesis.

Applications 5-phenyl-1,3-oxazolidin-2-one (cas# 7693-77-8) is a useful research chemical.

Applications 2,4-Diaminopyrimidine 3-N-Oxide is a useful organic synthetic reagent for the preparation of pyrimidines and in the making of hair loss and skin care compositions.
References von, A. S., et al.: Science of Synthesis, 16, 379 (2004); Mahe, Y., et al.: Skin Pharmacol., 9, 177 (1996); Hocquaux, M., et al.: From PCT Int. Appl. (1992), WO 9201437 A1 19920206

Applications 6-Methoxy-N2-methylpyridine-2,3-diamine dihydrochloride (cas# 83732-72-3) is a useful research chemical.

Applications 5-(Ethylthio)-1h-tetrazole

Applications 6-amino-5-chloro-2-cyclopropylpyrimidine-4-carboxylic Acid (cas# 858956-08-8) is a useful research chemical.

Impurity Carglumic Acid Impurity B
Applications 3-(2,5-Dioxoimidazolidin-4-yl)propanoic Acid is defined as combinational markers to distinguish hepatocellular carcinoma (HCC) from cirrhosis (CIR).
References Shao, Y., et al.: J. Proteome Res., 14, 906-916 (2015)

Impurity Flecainide EP Impurity B
Applications 2-Piperidinemethanamine is used in the synthesis of compounds exhibiting anti-osteoclast and anti-osteoblast activity. It also is used in the synthesis of potent antibacterial.
References Reddy, G. et al.: Hetero. Chem., 23, 247 (2012); Fujita, M. et al.: Chem. Pharm. Bull., 46, 787 (1998);

Applications 1-Formylpiperazine (cas# 7755-92-2) is a useful research chemical.

Stability Air Sensitive, Light Sensitive
Applications 3,4-DIETHYLPYRROLE (cas# 16200-52-5) is a useful research chemical.

Applications 4-Aminoimidazole is used as a building block for the synthesis vitamin B12-analogs via Eubacterium limosu.
References Endres, B. et al.: Biol. Chem. Hop.-Sey., 376, 595 (1995);

Impurity Terazosin EP Impurity M
Applications 1,4-Di-2-furoyl-piperazine (Terazosin EP Impurity M) can be used in biological studies to examine the relationship of structure to parasiticide activity of nitrated derivatives.
References Cavier, R., et al.: Chimica Therapeutica 5, 270 (1970)

Applications 3-Cyanopyridine is used in the preparation of arylthiazolines and arylimidazolines via dibromodimethylhydantoin-catalyzed condensation of aryl nitriles with ethylene diamine or aminoethanethiol.
References Hojati, S. F., et al.: Can. J. Chem., 88, 135 (2010);

Applications An intermediate in the synthesis of Prasugrel (P701150).

Applications 2,4,6-Tris[bis(methoxymethyl)amino]-1,3,5-triazine (cas# 3089-11-0) is a useful research chemical.

Impurity Pantoprazole EP Impurity C; Pantoprazole USP Related Compound C
Applications Pantoprazole EP Impurity C. Pantoprazole USP Related Compound C.

Applications O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium Tetrafluoroborate is used in the synthesis of tetrapeptoid analogues of the antiprotocoal compound Apicidin (A726300). Also used in the synthesis of acid based t-antigen glycodendrimers.
References Murray, P. et al.: Bioorg. Med. Chem. Lett., 11, 773 (2001); Roy, R. et al.: J. Am. Chem. Soc., 123, 1809 (2001);

Applications 1-(9-Fluorenylmethyl)piperidine is an intermediate when synthesizing 9-​Fluorenylmethoxycarbonyl group (FMOC), which is a new amino-protecting group.
References Carpino, L., et al.: J. Org. Chem., 37, 3404 (1972)

Applications 1-Amino-imidazolidine-2,4-dione (cas# 6301-02-6) is a useful research chemical.

Stability Hygroscopic
Applications 4-Diphenylmethoxypiperidine, HCl

Stability Light Sensitive
Applications A reagent for the determination of aldehydes and other reactive chemicals.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Dickinson, R.G. and Jacobsen,N.W. : Chem. Commun., 1719, (1970), Del Nozal, M.J. et al.: J. Liq. Chromatography, 16, 1105 (1993),

Applications Intermediate in the production of Methotrexate
References Chiosis, G., et al.: Bioorg. Med. Chem., 10, 3555 (2002), Palanki, M., et al.: J. Med. Chem., 50, 4279 (2007), Zav'yalov, S., et al.: Pharm. Chem. J., 42, 51 (2008),

Applications 4,5-Diamino-1-(2-hydroxyethyl)pyrazole Sulfate is useful as an oxidative hair dye.
References Hodes, J., et al.: PCT Int. Appl. (2020), WO 2020126225 A1

Applications Orotic Acid Monosodium Salt is used in the formation of a complex with lanthanium(III) which displats cytotoxic activity on different tumor cell lines.Also, it is the unlabeled form of Orotic Acid-15N2 Monosodium Salt (O691517), which is an intermediate used in the synthesis of Orotic Acid-15N2 Monohydrate (O691504), which is a labeled analogue of Orotic Acid Monohydrade (O691500), which is used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment.
References Kostova, I., et al.: Int. J. Curr. Chem., 1, 271-280 (2010)

Applications 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is used in preparation and structure of alkaline earth iodide phosphine oxide and urea complexes as reactant or reagents.
References Fitts, Lacey S., et al.: New J. of Chem., (2016); Hall, Jessica E., et al.: Angew. Chem. Int. Ed., 55, 11153-11157 (2016)

Applications Used for preparation of thieno-tetrahydropyridines useful as class III antiarrhythmic agents.
References Bahekar, R., et al.: Bioorg. Med. Chem., 15, 5950 (2007), Hayakawa, M., et al.: Bioorg. Med. Chem. Lett., 17, 2438 (2007),

Applications Oxidation and chlorination reagent.

Applications Pyridine-2-aldoxime (cas# 873-69-8) is a useful research chemical.

Applications An intermediate in the production of many biological inhibitors.
References Lambertucci, C., et al.: Bioorg. Med. Chem., 17, 2812 (2009), Lebsack, A., et al.: Bioorg. Med. Chem. Lett., 19, 40 (2009), Griffith, D., et al.: J. Med. Chem., 52, 234 (2009),

Applications 1-(oxan-4-yl)-1H-1,2,3-triazole-4-carboxylic acid (cas# 1487610-80-9) is a useful research chemical.

Applications α-Phenyl-2-pyridineacetamide (cas# 7251-52-7) is a compound useful in organic synthesis.

Applications 5-Hydroxy-N-methyl-2-pyrrolidinone is a metabolite of N-methylpyrrolidone (NMP).
References Payan, J., et al.: Drug Metab. Dispos., 30, 1418 (2002), Carnerup, M., et al.: Food Chem. Toxicol., 43, 1441 (2005), Angerer, J., et al.: Toxicol. Sci., 93, 3 (2006),