Building Blocks

<p>Versatile small molecule scaffold</p>

<p>2-(3,4,5-Trimethoxyphenyl)ethanol is a conjugate of 3,4,5-trimethoxybenzaldehyde and ethanol. It has shown in vitro antifungal activity against Candida strains and antibacterial activity against Escherichia coli and Staphylococcus aureus. 2-(3,4,5-Trimethoxyphenyl)ethanol can be used as an antifungal agent in the treatment of fungal infections. It has also been shown to act as an acetoacetate receptor for the conversion of acetoacetate into acetoacetyl CoA during fatty acid synthesis. This compound has also been used in the synthesis of mescaline.</p>

Versatile small molecule scaffold

<p>4-Methanesulfinylbenzaldehyde is an antiinflammatory agent that inhibits the production of prostaglandin E2 (PGE2) by inhibiting the conversion of arachidonic acid to PGE2. It also has antioxidant properties, which may be due to its ability to inhibit peroxide oxidation. 4-Methanesulfinylbenzaldehyde is used in the treatment of inflammatory skin diseases such as atopic dermatitis, acne vulgaris and psoriasis.</p>

<p>Methyl (1S,2R,3R,8S)-4-bromocubane-1-carboxylate is an experimental compound that has been shown to produce efficient crystallization of various organic compounds. It is a vicinal difunctional reagent with the carbonyl group on one end and the fluorine atom at the other. It is an X-ray sensitive substance and can be used for x-ray diffraction studies. This compound is also useful for preparing carbonyl fluorides. Methyl (1S,2R,3R,8S)-4-bromocubane-1-carboxylate can be used in crystallography studies because it forms well defined crystals in space groups P21/n and P21/c.</p>

<p>Versatile small molecule scaffold</p>

<p>5-(Aminomethyl)benzo[b]furan is a drug that has been shown to inhibit the histamine h3 receptor and transcriptase. It has been used in the treatment of allergic reactions, such as those caused by histamine release. The drug is classified as a non-nucleoside inhibitor of reverse transcriptase. 5-(Aminomethyl)benzo[b]furan has also been shown to be effective against viral strains that are resistant to nucleoside analogues, such as HIV-1, HIV-2, and influenza A. 5-(Aminomethyl)benzo[b]furan binds to the active site of reverse transcriptase and inhibits the synthesis of viral RNA from single-stranded DNA. This binding prevents the formation of a double-stranded DNA with complementary RNA template necessary for viral replication.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>O-[(3-Pyridyl)methyl]hydroxylamine is an epimer of hydroxylamine. It is a nucleic acid that can be enzymatically synthesized and is used in the synthesis of oligosaccharides with uronic acids, such as dermatan sulfate. O-[(3-Pyridyl)methyl]hydroxylamine attacks sulfated glycosaminoglycans and glycosaminoglycan chains in the skin, causing a loss of water from the skin. This drug has been shown to have affinity for dermatan and deuterium, which may result in its use as a marker for dermatan sulfate.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

2-(2-Bromoethyl)-2-methyl-1,3-dioxolane is a carbonyl compound that can be used to form an asymmetric epoxide from an ethylene. This product has been shown to produce isolated yields of ketones and acetals. It is a reagent for the asymmetric synthesis of alcohols and amines. 2-(2-Bromoethyl)-2-methyl-1,3-dioxolane also reacts with benzene in the presence of an acid catalyst to give a mixture of epoxides.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>2',4'-Dichloropropiophenone is an organic solvent that is used in pharmaceuticals. It has been shown to be a versatile reagent for the synthesis of chalcones and other types of compounds. 2',4'-Dichloropropiophenone can be used in the cross-coupling reaction, which involves the coupling of two organic molecules using a metal catalyst (usually copper) to generate new compounds. The dehydrohalogenating reaction, which involves the conversion of epoxides into alcohols, can be performed with 2',4'-dichloropropiophenone. This compound also reacts with amines to form oximes or aziridines and with epoxy groups to form epoxy ethers. Finally, it is an oxidant that can react with benzene to produce phenols, biphenyls, or nitrobenzenes.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Quinoxalines are a class of heterocyclic compounds that is structurally related to the more common amino acid, tryptophan. They are typically synthesized by modifications of the quinoxaline ring system with epoxide, amine, or carbonyl groups. Quinoxalines can be analyzed using many different techniques including gas chromatography-mass spectrometry, liquid chromatography-mass spectrometry, and nuclear magnetic resonance spectroscopy. The most common modification is the addition of an aminoguanidine group that is used to distinguish between 2-ethyl-3-methylquinoxaline and 3-ethyl-2-methylquinoxaline. The reaction time between glyoxal and aniline to produce 2-ethyl-3-methylquinoxaline can be optimized by adding potassium dichromate as a catalyst.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>5,6,8,9-Tetrahydrobenzocyclohepten-7-one is a methylated analogue of benzocycloheptene. It is prepared by the reaction of dichlorocarbene (1) with 7-hydroxybenzocycloheptene (2). The deuterium isotope effect on the conformation of 5,6,8,9-tetrahydrobenzocyclohepten-7-one has been investigated using a spectroscopic technique. The reaction parameters have been optimized for this transformation to produce the desired product in high yield.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3H,4H-Pyrido[3,2-d][1,2,3]triazin-4-one is a heterocyclic compound that belongs to the group of endometriosis drugs. It has been shown to inhibit tyrosine kinase and thus has a proliferative effect on the skeleton. 3H,4H-Pyrido[3,2-d][1,2,3]triazin-4-one also has an antiangiogenic activity that prevents the formation of new blood vessels from pre-existing ones. This drug also inhibits tumor growth by blocking cell division and may cause cancerous cells to self destruct. 3H,4H-Pyrido[3,2-d][1,2,3]triazin-4-one can be used to treat symptom of endometriosis such as pain and infertility.</p>

<p>Ethyl 1H-pyrrole-3-carboxylate is a nitro compound that has been shown to be efficient and multisubstituted. It reacts with carbon monoxide to form a nitro group, which can then be reduced by reductive means. Ethyl 1H-pyrrole-3-carboxylate is also capable of forming vinyl or carbonyl compounds in the presence of appropriate reagents.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-4-ethynylpyrimidine is a chemical compound that belongs to the family of meridianins. It has been shown to have medicinal properties, and is used in the treatment of trypanosomiasis. This molecule also has physicochemical properties that warrant further investigation. Optimization studies have shown that 2-chloro-4-ethynylpyrimidine can be synthesized with yields of up to 76% using nitrosoarenes as reactants.</p>

<p>Versatile small molecule scaffold</p>

<p>1-Nitro-3-(phenylsulfanyl)benzene is a compound that belongs to the class of organic compounds with a molecular formula C11H10O3S. It has a transmittance of 0.10 and a polycondensation value of 3.2. The conformation of 1-nitro-3-(phenylsulfanyl)benzene is linear, and it has an average refractive index of 1.5214. This compound has high stabilities, as well as being n-methyl-2-pyrrolidone and sulfur stable, with birefringence values of 0.0805 and -0.0125 respectively. The steric effect on this compound is negligible, with the refractive index being polarizable in optical activity experiments, with an average optical rotation value of -5°/Mol at 20°C (298K).</p>

<p>1,4-Diphenylbutan-2-one is a chemical compound that has been shown to have anticancer activity. It is an inhibitor of the enzyme tyrosinase and can be used as an anti-cancer treatment. 1,4-Diphenylbutan-2-one binds to the active site of tyrosinase and blocks the formation of melanin, which is the pigment in skin cells that gives the skin its color. 1,4-Diphenylbutan-2-one also inhibits growth factor receptors on cancer cells, which prevents tumor growth. This drug has minimal toxicity levels in humans and has been shown to have minimal interactions with other drugs or substances.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Importazole is a protein that inhibits the polymerase chain reaction (PCR) by binding to the DNA strand. It has been shown to inhibit cancer cell proliferation and induce apoptosis in HL-60 cells. Importazole also prevents the binding of taxane drugs to nuclear receptors, which may be beneficial for chemotherapy treatment. Importazole binds to DNA and blocks transcriptional regulation, which leads to neuronal death in rats. This protein has been shown to bind to both DNA and receptor activity, and also has an effect on cell nuclei.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>6-Chloro-5-methyl-2,3-dihydro-1H-indole is a 5HT receptor agonist that has been shown to be an effective antidepressant in animal models. It has a high affinity for the 5HT2A and 5HT2C receptors, but does not bind to other serotonin receptor subtypes. 6-Chloro-5-methyl-2,3-dihydro-1H-indole also possesses oral activity and is selective for the 5HT2A receptor subtype. The compound has been cloned and evolutionarily optimized to produce a more potent and selective compound.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>2-Bromo-5-isopropoxybenzaldehyde is an isopropoxy analog of the natural product suzukol. It has been synthesized by a novel methodology involving oxidative bromination of the phenylacetone. This compound has been used as a model for the synthesis of 2,3,4,5-tetrahydrobenzofuran and can be used as a starting material for the synthesis of other natural products.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>3-Amino-5-methoxyphenol is a chiral compound with two enantiomers. It has been shown to inhibit tumour growth and to have antitumour properties. 3-Amino-5-methoxyphenol has also been found to be effective against Gram-positive bacteria, such as methicillin resistant Staphylococcus aureus (MRSA). 3-Amino-5-methoxyphenol binds to the active site of bacterial ribosomes and inhibits protein synthesis. This leads to cell death by inhibiting the production of proteins vital for cell division. 3-Amino-5-methoxyphenol can also be used as an antibiotic in humans because it does not affect the metabolism of human serum.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>