Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Sulfamoylbenzamide is a sulfonamide that has been modified to improve its selectivity and potency. The modification of 4-sulfamoylbenzamide has been studied with anhydrase, which is an enzyme found in the eye that can cause glaucoma. The modifications allow this drug to selectively target the cytosolic isoforms of anhydrase. This drug also has anti-proliferative activity and can be used for the treatment of certain types of cancer, including breast, lung, prostate, and colon cancer. 4-Sulfamoylbenzamide was first synthesized in 1964 and was approved by the FDA in 1968 for use as an ophthalmic agent.

4-[(Aminocarbonyl)amino]benzoic acid is an antibacterial fatty acid that is structurally related to the antimicrobial agents known as cyanates. It has a reactive center that can undergo a halogenation reaction with halides and a substitution reaction with carboxylic acids to form reactive compounds. 4-[(Aminocarbonyl)amino]benzoic acid has shown tuberculostatic activity against the bacteria Typhimurium and subtilis, and is effective against antifungal strains of yeast such as Candida albicans, Candida krusei, and Candida tropicalis. 4-[(Aminocarbonyl)amino]benzoic acid also has a molecule that can be used in the synthesis of diisocyanates.

Versatile small molecule scaffold

4-Chloropyridine-2,6-diamine is a compound that contains nitrogen and carbon. It has been synthesized experimentally and the crystal structure has been determined by X-ray crystallography. This substance belongs to the class of heterocycles and it is a hydrogen bond acceptor. The crystal structure of 4-chloropyridine-2,6-diamine has been rationalized using experimental data. The electron density maps show that there are six moles of naphthalene for every mole of 4-chloropyridine-2,6-diamine in the crystal lattice.
4-Chloropyridine-2,6-diamine is an enthalpy donor because it donates its electrons to other substances. It also accepts hydrogen bonds from other substances. This substance can form supramolecular frameworks with pyridine and benzene molecules, which stabilizes the molecule's structure through coval

Versatile small molecule scaffold

3-Methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine is a purine ligand that can be protonated at the N7 nitrogen. It has been shown to have biological properties such as anion binding and also shows strong dichroism spectra. The structure of 3-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine has been determined by X-ray crystallography and magnetic resonance spectroscopy. This ligand is not easily protonated in aqueous solution due to its high basicity. The protonation state of this ligand is sensitive to pH changes in the environment.

6-Chloro-2-oxo-1,2-dihydropyridine-4-carboxylic acid (6CODPC) is a carboxylic acid that is an active ingredient in some fungicides. It has been shown to inhibit the growth of certain plant pathogens such as viruses and bacteria. 6CODPC binds to the enzyme ribonucleotide reductase, which is involved in DNA synthesis and replication, leading to the inhibition of RNA synthesis and protein synthesis. This leads to cell death by apoptosis. 6CODPC also inhibits the production of proteins in plants that are necessary for photosynthesis.

2-(3-Methylbenzyl)succinic acid is a sulfate metabolite that has been shown to regulate the activity of sulfate-reducing bacteria. It was first identified as a major metabolite in incubations with benzylsuccinic acid and xylene. The isomers of 2-(3-methylbenzyl)succinic acid are benzoate and hydroxyphthalide. The geochemical significance of this compound is not yet known, but it may signify the presence of microbial metabolism in the environment. The compound can be found at nanomolar concentrations in natural environments and has been shown to inhibit microbial growth by mechanisms that remain unclear.

Versatile small molecule scaffold

N-Benzylpyridine-4-carboxamide is a synthetic compound that has been shown to have anticancer, anti-inflammatory, and neuropathic properties. This compound is an innovative drug candidate for the treatment of inflammatory diseases and cancer. N-Benzylpyridine-4-carboxamide inhibits the production of chemokines, which are cytokines that are involved in the recruitment of cells to sites of inflammation and infection. The mechanism involves the ring opening of the amide bond between the nitro group and the carboxylic acid group. The pharmacophore is derived from this ring opening reaction. This compound also blocks receptor subtypes such as 5HT3A or NMDA receptors, which may lead to neuropathic effects.

2-(4-Benzoylphenoxy)acetic acid is a phenoxy compound that can be used as an antinociceptive agent. It has been shown to inhibit the pain response in mice by binding to the peripheral cannabinoid receptor CB2 and blocking intracellular calcium channels, thereby inhibiting the release of pro-inflammatory molecules. 2-(4-Benzoylphenoxy)acetic acid also inhibits the activity of two enzymes involved in carbonic acid production and glucose metabolism, which may provide protection against metabolic disorders. Computational methods have been used to model the molecular structure of 2-(4-benzoylphenoxy)acetic acid, which are then compared with experimental data on hydrogen bonding interactions between dihedral angles and intramolecular hydrogen bonds.

Versatile small molecule scaffold

2-Amino-5-chloro-3-nitrobenzoic acid is a synthetic compound that has been shown to have topoisomerase activity. It binds to the DNA of cancer cells and inhibits the expression of certain genes, which inhibits cell proliferation. 2-Amino-5-chloro-3-nitrobenzoic acid also interacts with the drug transport protein p-glycoprotein, inhibiting its function and leading to multidrug resistance in cancer cells. This drug has been shown to be cytotoxic for lung carcinoma cells.

5-Cyclohexyl-5-methylimidazolidine-2,4-dione is a ligand that binds to the receptor and activates it. It is used in research as a tool for studying ion channels, peptides, and protein interactions. 5-Cyclohexyl-5-methylimidazolidine-2,4-dione has been shown to inhibit the binding of an antibody to its antigen.

Versatile small molecule scaffold

Versatile small molecule scaffold

Bis(2-phenylethyl)amine hydrochloride (BPEA) is a compound that has been shown to have neuroprotective effects in animal models of Alzheimer's disease. This compound has been found to inhibit the formation of reactive oxygen species, which are responsible for neuronal cell death. BPEA also inhibits the enzyme amine oxidase, which is responsible for the breakdown of neurotransmitters and may be involved in the development of Alzheimer's disease and other neurodegenerative diseases. BPEA has been shown to be effective in preventing and treating symptoms of Alzheimer's disease in an experimental model. Dipropylamine (DPEA), a known inhibitor of amine oxidase, was tested with BPEA and found to have synergistic effects. DPBA was not able to prevent or treat symptoms when given alone.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

This is a pyridine compound that is used in the nitration of aromatic compounds. It can be synthesized by reaction of 2-aminopyridine with nitric acid and sulfuric acid, followed by filtration and recrystallization. The experimental procedure for this compound is not currently available.

Versatile small molecule scaffold

2-Amino-3,4,6-trichlorophenol is a versatile compound that has various applications in different fields. It is commonly used in chromatographic analysis as a reference standard and as a reagent in organic synthesis. This compound is also found naturally in plants such as monoterpenoids, isoflavones, pyrazoles, alkaloids, and chalcones. Additionally, it has been identified as a component of certain research chemicals.