Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Chloro-6-(trifluoromethyl)benzoic acid is a plant growth regulator that inhibits the ethylene synthesis. It is used to stimulate plant growth, particularly in fruit trees and vines. 2-Chloro-6-(trifluoromethyl)benzoic acid binds to an enzyme called ACC synthase that is responsible for converting acetate into ethylene. This binding prevents the formation of ACC, resulting in lower levels of ethylene production.

3-Methoxythioanisole is a transfer catalyst that catalyzes the transfer of hydrogen peroxide from an alkali metal salt to an organic substrate. The reaction proceeds via a monoprotonated intermediate. 3-Methoxythioanisole can be used for the synthesis of esters, amides and nitriles. 3-Methoxythioanisole is also a hydrophilic catalyst and can be used in phase transfer catalysis. This compound is derived from the oxidation of thiophene by hydrogen peroxide, which produces a polyoxometalate as a byproduct. 3-Methoxythioanisole has been shown to be effective in catalyzing reactions between ammonium salts and phosphotungstate, yielding ammonium tungstate or hydroxylammonium tungstate as products.

Versatile small molecule scaffold

Bromocycloheptane is a c6 alkyl that functions as an uptake inhibitor. It is used in the synthesis of other organic compounds, such as imidazole derivatives. Bromocycloheptane has been shown to inhibit uptake in the brain and consequently reduce infarctions in animal models of Alzheimer's disease. Bromocycloheptane inhibits uptake by blocking the function of the carrier protein, which carries neurotransmitters from synapses to axons and dendrites. Bromocycloheptane binds to magnesium ions, which are necessary for hydrolysis of ATP and therefore for uptake into cells. The magnesium ion is found in many enzymes involved in cellular processes, including those that produce ATP, so bromocycloheptane may interfere with cell function by interfering with these enzymes. This drug also blocks the production of lactam, a precursor molecule to GABA, which can be synthesized by glutamic acid decarboxyl

Versatile small molecule scaffold

Versatile small molecule scaffold

Octahydroindolizin-7-one is a heterocyclic compound that has been isolated from the fungus Ganoderma lucidum and the bacterium Streptomyces griseus. It has an enamine structure, which can be converted to an amine by reduction with lithium aluminum hydride. Octahydroindolizin-7-one has been shown to inhibit bacterial growth through the inhibition of protein synthesis.

1-Methyl-3,4-dihydroisoquinoline is a chemical compound that is used in the synthesis of 1-methyl-3,4-dihydroisoquinoline N-oxide. 1,2-Dihydroisoquinolines are amine derivatives that are important for their physiological properties. The asymmetric synthesis of 1,2-dihydroisoquinolines is important for the development of new drugs and pharmaceuticals. This reaction scheme includes two steps: the first step involves the condensation of an imine with a catecholamine to form an imine; the second step involves cyclization of this imine to form a 1,2 dihydroisoquinoline. The use of additives such as sodium methoxide or dimethylsulfate can increase selectivity and yield by stabilizing one enantiomer over another. The products from this reaction are methylated with methyl iodide in the presence of potassium

Versatile small molecule scaffold

2,2,3,3-Tetramethylcyclopropyl)methanol is a reagent that is used in the synthesis of insecticides and in the preparation of other organic compounds. It is prepared by reacting phosphorus with chlorinating agents such as thionyl chloride or phosphoryl chloride. This chemical can also be synthesized from halogenated alkanes by catalytic chlorination. 2,2,3,3-Tetramethylcyclopropyl)methanol has been employed as a Grignard reagent and Wittig reaction catalyst.

Versatile small molecule scaffold

Quinoxaline-1,4-diium-1,4-bis(olate) is a genotoxic agent that has been shown to cause DNA damage and mutations. In vitro assays have shown that this substance is reactive with human serum in a photochemical reaction, which generates malonic acid and oxidative DNA. It also inhibits bacterial growth by binding to the bacterial 16S ribosomal RNA molecule, thereby inhibiting protein synthesis. This substance has been shown to be active against solid tumours in vivo. The structure of quinoxaline-1,4-diium-1,4-bis(olate) contains a chlorine atom at position 1 and 4 of the aromatic ring system. This chlorine atom can be displaced by an n-oxide group or reduced to form a quinone methide species. These reactions are thought to be responsible for the biological properties of this compound.

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Hydroxynaphthalene-1-carboxylic acid is a natural product that inhibits the growth of bacteria. It was first isolated from Streptomyces lividans, an actinobacterium, and was shown to be effective against gram positive and gram negative bacteria. 5-Hydroxynaphthalene-1-carboxylic acid has been used to study the molecular structure of benzene derivatives, including biphenyls, which are responsible for the degradation of polychlorinated biphenyls (PCBs). The skeleton structures found in 5-hydroxynaphthalene-1-carboxylic acid were determined to be monosubstituted by substituent effects. This natural product also has antiinflammatory properties.