Building Blocks

2-Hydroxy-2,3,3-trimethylbutanoic acid is a molecule that has been used in the synthesis of ligands and is also used to stabilize the carboxylic acid group. The protonation of this molecule leads to its acidic properties, which are useful for many purposes, including as a precursor for insect pheromones. The addition of chloride ions to 2-hydroxy-2,3,3-trimethylbutanoic acid produces an ion with a mononuclear charge that can be detected by nmr spectroscopy. This molecule forms hydrogen bonds with water molecules.

3-Chloroquinoxaline-2-carboxylic acid (3CQC) is a halogen atom, oxadiazole, benzene, alkoxycarbonyl, alkoxy, cyano, trifluoromethyl, dihedral and halogen. 3CQC is used as a chemical intermediate in organic synthesis. It can be used as a starting material for the synthesis of other organic compounds and pharmaceuticals. 3CQC has been found to inhibit bacterial growth by inhibiting RNA polymerase. This compound also inhibits protein synthesis by binding to the ribosome's 50S subunit and prevents the production of proteins vital for cell division.

Versatile small molecule scaffold

5-Nitro-2-(morpholin-4-yl)benzoic acid is a cytotoxic agent that induces apoptosis in cells. This compound binds to tubulin and inhibits its polymerization, which leads to the disruption of microtubules. 5NMBA has potent cytotoxicity against cancer cells, including human lung cancer cells. It has been shown to be a potent inhibitor of paclitaxel polymerization, and also can disrupt the polymerization of other drugs such as colchicine and vinblastine. 5NMBA expresses itself at high levels in human lung cancer tissues and is often found in multidrug resistant tumor cells.

Versatile small molecule scaffold

Propargyl benzyl ether is an organic compound with the formula CHCH=C(CH)OCH. It is a colorless liquid that has been used as a synthetic intermediate in organic synthesis. Propargyl benzyl ether has been shown to induce apoptotic cell death, which may be due to its ability to bind and inhibit the activity of pyrazole-3-carboxamide ribonucleotide transformylase, an enzyme involved in purine metabolism. This compound also induces apoptosis through the activation of caspases. The sample is pretreated before analysis by activating the cells with a solution of HCl and KOH before adding propargyl benzyl ether. Analysis is then conducted using analytical chemistry techniques such as gas chromatography or mass spectrometry. The chemical synthesis can be accomplished by reacting a β-unsaturated ketone with an acid catalyst such as HCl or acetic acid in the presence of a chelate ligand such as pyridine hydro

Bicyclo[2.2.1]heptan-2-ylmethanamine hydrochloride is a chemical compound that is used to treat inflammatory diseases. It has been shown to be effective in animals with experimental arthritis, and it has been found to suppress the production of nitric oxide, which is involved in inflammation. Bicyclo[2.2.1]heptan-2-ylmethanamine hydrochloride binds to proteins and peptides in the body, forming conjugates that are excreted in urine samples or plasma concentrations. The enantiomers of this drug have different effects on the body, with one being more potent than the other. It has been shown that this drug can inhibit cell dysfunction by modulating cell signaling pathways as well as inhibiting inflammatory responses via interactions with opioid receptors on cells. This drug also inhibits the production of inflammatory cytokines such as IL-6 and TNF-α by binding to their

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

N,N'-Di-tert-butylethylenediamine is a diamine compound that has been used as an optical reference in infrared spectroscopy and as a ligand for catalysis. It is soluble in organic solvents and has a magnetic susceptibility of 0.0014 cm3/mol. The optical properties of N,N'-Di-tert-butylethylenediamine are the result of a chromophore with an absorption maximum at 595 nm and emission maxima at 600 nm. This substance also has been shown to have functional groups that can be reduced to form peroxide radicals.

3-(2-Furyl)-DL-alanine is a chiral amino acid that is used as a building block in the synthesis of peptides and proteins. The enantiomers of 3-(2-furyl)alanine have been shown to have different properties. One enantiomer has been shown to be more soluble in cyclohexane and 2-propanol, while the other has been shown to be more soluble in water. This difference can be optimized by using an appropriate solvent or by adding a complexing agent such as sodium chloride. It also has been found that one enantiomer is more reactive than the other with metal ions such as copper(II).

Versatile small molecule scaffold

2-Benzoyl-5-chloroaniline is a synthetic chemical that can be used as an intermediate in the synthesis of other chemicals. It has been found in urine samples and is also used to prepare other compounds. 2-Benzoyl-5-chloroaniline is typically acetylated, salicylated, or trifluoroacetylated before use in order to protect against degradation by acidic conditions. This chemical can react with amines to form conjugates and has functional groups such as chloride and amines that are detectable by gas chromatography. 2-Benzoyl-5-chloroaniline regulates the activity of enzymes related to the metabolism of proteins and nucleic acids, which may be due to its ability to inhibit protein synthesis or DNA replication.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

N-Chloroacetyl-DL-valine is a natural amino acid with the formula CH3C(O)NH2. It is one of the 22 proteinogenic amino acids. The N-chloroacetyl group in this compound is attached to nitrogen at the α-position, and its carboxylic acid moiety is attached to the β-position of the amino acid backbone. In crystallized form, it has a n-terminal pyrolysable amide bond that can be cleaved by heat. In solution, it hydrolyzes readily to DL-alanine and chloroacetic acid. Aminoacylase and dipeptidase enzymes catalyze this reaction in vivo. NCA is an L-amino acid that contains an α-carbon atom with two substituents: an amide group (NHCOCH3) and a chloroacetyl group (CH3C(O)Cl). The molecular weight

Versatile small molecule scaffold

Cyclooctanecarboxylic acid is a hydroxylated monocarboxylic acid that has been shown to inhibit the activity of various enzymes. It is a polar molecule with a diameter of about 1.5 nm, which can be used as a polarizer in light microscopy. Cyclooctanecarboxylic acid has been shown to inhibit the production of hepatitis C virus particles and insulin resistance in mammalian cells. It also inhibits viral replication by interfering with the synthesis of viral proteins, inhibiting protein synthesis and cell division. Cyclooctanecarboxylic acid is an inhibitor for many compounds, including inhibitors for cholesterol biosynthesis, human immunodeficiency virus type 1 protease inhibitors, and protein kinase C inhibitors.

Versatile small molecule scaffold

4-Isocyanatocyclohex-1-ene is a colorless liquid that is soluble in water. It is used as a raw material for the production of polyurethane and other polymers, which are used in coatings, adhesives, elastomers, and other industrial applications. 4-Isocyanatocyclohex-1-ene can be found as part of a mixture or polymer with other diisocyanates. The chemical has been shown to form when certain cycloaliphatic compounds are heated to high temperatures.

4-Ethylpiperazine-1-sulfonamide is a potent compound that inhibits the production of lipopolysaccharide. This inhibition leads to less inflammation and pain in patients with rheumatoid arthritis and other inflammatory diseases. 4-Ethylpiperazine-1-sulfonamide has been shown to inhibit the production of tumor necrosis factor alpha (TNFα) in human macrophages by blocking the activation of nuclear transcription factor kappa B (NFκB). This compound also binds to the TNF receptor, inhibiting its ability to activate NFκB. 4-Ethylpiperazine-1-sulfonamide also has antiinflammatory activities and can be used for the treatment of chronic inflammatory disorders such as rheumatoid arthritis.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

(S)-3-Amino-2-pyrrolidinone is a potent inhibitor of serine proteinases, including trypsin, chymotrypsin, and elastase. It also has anti-coagulant properties that are similar to heparin. (S)-3-Amino-2-pyrrolidinone is used in the treatment of carotid artery disease and as an anticoagulant in deep vein thrombosis prophylaxis. This drug can be used in the prevention or treatment of thrombus formation due to its ability to inhibit coagulation and fibrinolysis. It is also a potent inhibitor of thrombin, which is an enzyme involved in blood coagulation. The development of this drug was inspired by the discovery of the importance of serine protease inhibitors for blood clotting and other physiological processes.

2-Amino-4-chlorobenzene-1-sulfonamide is a sulfa drug that inhibits the growth of bacteria by inhibiting the synthesis of folic acid. It is used for the treatment of staphylococcus and other bacterial infections, although it does not show any effect on gram negative bacteria. 2-Amino-4-chlorobenzene-1-sulfonamide binds to enzymes in the bacterial cell wall, which prevents them from synthesizing folic acid. This results in inhibition of DNA synthesis and protein synthesis, leading to cell death. 2-Amino-4-chlorobenzene-1-sulfonamide also shows antibacterial activity against Salmonella typhi and Shigella dysenteriae because these organisms are sensitive to sulfa drugs.

5-Benzoylpentanoic acid is a chemical compound that has been shown to be an effective bactericidal agent against Gram-positive and Gram-negative bacteria. It is synthesized by the hydrogenation reduction of 5-benzoylpentanal, which is obtained from the oxidation of benzaldehyde with nitric acid. The synthesis of 5-benzoylpentanoic acid can be carried out in two steps: first, a benzaldehyde ester is obtained by reacting benzaldehyde with methyl acrylate in the presence of a base; second, the ester reacts with sodium hydroxide to produce 5-benzoylpentanoic acid. This chemical is also an organic solvent that can be used in the organic synthesis of other compounds. This compound has been shown to have inhibitory activity against oxocarboxylic anions such as phosphoric acid and perchloric acid.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Ethylhexanamide is a fatty acid amide that is metabolized by the liver. It has been shown to have antiepileptic activity in animal models, and can be used as a substitute for phenytoin. 2-Ethylhexanamide is also metabolized to form an amide with chloride ions, which may be responsible for its anti-epileptic effects. The pharmacokinetics of 2-ethylhexanamide are well understood in animals and humans, where it is eliminated unchanged in the urine. This drug also has functional groups that allow it to react with other compounds and undergo biotransformation reactions.

3-(Propan-2-yl)pentanedioic acid is an oxidation product of α-pinene, β-caryophyllene, and isoprene. It has been used as a tracer in gas chromatography/mass spectrometry to identify the sources of carboxylic acids in tobacco smoke. The compound has also been used as an analytical standard for carboxylic acids and lactones. 3-(Propan-2-yl)pentanedioic acid is found in high concentrations in aerosols from e-cigarettes, which have been shown to contain other compounds that may be harmful to health.

1-(1,2,3,4-Tetrahydroquinolin-1-yl)ethan-1-one is a hdac inhibitor that binds to the enzyme histone deacetylase (hdac). It has been used to study Alzheimer's disease and other neurodegenerative diseases. This drug is an amide with a carbonyl group. It is also a biphenyl molecule that can be prepared by reacting phosphorus pentoxide with biphenyl. 1-(1,2,3,4-Tetrahydroquinolin-1-yl)ethan-1-one has shown inhibitory effects on metal hydroxides such as calcium hydroxide and magnesium hydroxide. 1-(1,2,3,4-Tetrahydroquinolin-1-yl)ethan-1-one also inhibits the formation of hydrochloric acid from hydrogen chloride and sodium hydroxide. The aromatic hydro

Versatile small molecule scaffold