Building Blocks

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>4-chlorotetrahydro-2H-thiopyran 1,1-dioxide is an experimental heterocyclic compound. It has a dipole and a methylcyclohexane ring with an axial orientation. The density of the molecule is 1.499 g/cm3. This compound has conformational energies and substituents that are stable at room temperature. Theory predicts that this compound will have 3 conformers, all of which are energetically favorable, with one being more stable than the others. The energies and conformers are influenced by the steric interactions between substituents and cyclohexanes in the molecule. 4-chlorotetrahydro-2H-thiopyran 1,1-dioxide has no electrostatic interactions because it does not have any electronegative atoms or groups.</p>

<p>Versatile small molecule scaffold</p>

<p>2-(2-Bromo-5-hydroxyphenyl)acetic acid is a hydroxylation product of melatonin. It has been shown to be a potent and selective agonist for the melatonin receptor, with an EC50 of 0.4 nM. 2-(2-Bromo-5-hydroxyphenyl)acetic acid is also a potent microbial sodium hydrogen (MSH) receptor antagonist with an IC50 of 9 nM.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methylsulfonylthiophene is a modulating agent that can inhibit the activity of carbonic anhydrase, adenosine receptors and 5-membered heteroaryl. It has been shown to have affinity for CB1 receptor antagonists and is used to treat cardiovascular diseases. 2-Methylsulfonylthiophene also inhibits the enzymatic activity of anhydrase in the eye, which leads to suppression of intraocular pressure (IOP). The drug also has anti-glaucoma effects by reducing the production of aqueous humour. 2-Methylsulfonylthiophene is used as a dyestuff intermediate and as an organic solvent.</p>

<p>(2-Methoxypyrimidin-4-yl)methanol is a photoreactive molecule that can be synthesized by the dehalogenation of diethylamine and methylated with methanol. The reaction produces a derivative of pyrimidine, which is an important precursor for pharmaceuticals. When irradiated with UV light, (2-methoxypyrimidin-4-yl)methanol undergoes a series of reactions to form the desired pyrimidine product. This reaction proceeds through electron transfer from the amine nitrogen to the methoxy group on the pyrimidine ring. This process yields a 5 membered ring with two oxygen atoms and one nitrogen atom, in contrast to the 6 membered ring formed by other methods.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Dimethylamino)acetaldehyde Dimethyl Acetal is a pharmaceutical preparation that is used as an organic solvent. It has a viscosity of 0.1 cP and is a colorless liquid with a molecular weight of 117. It reacts rapidly with alkyl halides, hydroxyl groups, and reactive alkoxy radicals to form (dimethylamino)acetaldehyde dimethyl acetal. This product has shown some surface activity in acidic solutions and the presence of alcohols and other hydrocarbons can reduce its reactivity.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

3-Hydrazinyl-6-methyl-4H-1,2,4-triazin-5-one is a chemical compound that belongs to the group of aromatic aldehydes. It has been shown to react with elemental chlorine, forming 3-chloro-6-methyl-4H-[1,2,4]triazin-5(3H)-one. This reaction can be accomplished by photolysis or pyrolysis. The magnetic properties of this compound allow for its use in studies involving electron spin resonance spectroscopy and nuclear magnetic resonance spectroscopy. 3-Hydrazinyl-6-methyl-[1,2,4]triazin-[5-(3H)]one can also undergo a photochemical reaction when exposed to ultraviolet radiation with molecular oxygen. The mechanism of this reaction is not fully understood but it is thought to involve electron transfer from the excited state of the 3 hydrazine molecule to an oxygen molecule followed by

<p>3-Bromo-L-tyrosine is a reactive eosinophilic compound that is formed in human serum during the activation process. 3-Bromo-L-tyrosine has been used as an analytical method for the measurement of eosinophil peroxidase and tissue culture cells. 3-Bromo-L-tyrosine has also been shown to be a marker for infectious diseases, such as cytomegalovirus (CMV), influenza, and parainfluenza virus infections. This compound can also be used to evaluate the efficacy of treatments for infectious diseases, such as CMV and influenza.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Methyl 5-methoxypyrazinecarboxylate is an organic compound that belongs to the group of triazoles. It has been used as a pesticide for the control of plant pathogenic fungi, nematodes and insects, such as dextrose, chloride, oxadiazoles and agriculturally. This product is effective against pests at low doses. Methyl 5-methoxypyrazinecarboxylate inhibits the synthesis of proteins in plants by inhibiting chitin synthase enzymes in fungi and nematodes. It also inhibits the synthesis of proteins in insects by interfering with the synthesis of proteins involved in cell division.</p>

<p>5-Methoxypyrazine-2-carbonitrile is a reactive, electron-deficient heterocycle that is used as a synthetic intermediate in organic synthesis. The reactivity of this molecule is similar to that of the cyanide ion, which can be used for the selective incorporation of carbon monoxide into organic molecules. 5-Methoxypyrazine-2-carbonitrile has been shown to react with trimethylsilyl cyanide, forming the corresponding trimethylsilyl cyanohydrin. This reaction proceeds via an anti-Markovnikov addition and produces a hemiaminal product.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-6-hydroxybenzoic acid is a nucleophilic compound with a bromine atom at the 2 position. It is used in organic synthesis as a building block in the preparation of amides and other functional groups. This efficient preparation can be achieved by treating anilines with sodium nitrite and hydroxylamine in ethanol.</p>

<p>3-Bromo-4,5-dihydroxybenzonitrile is a molecule that has been found to be effective in treating neurodegenerative diseases. It has been shown to inhibit gene transcription, leading to the inhibition of cell proliferation and apoptosis. This drug also inhibits N-acetylglucosamine glycosylase, an enzyme that is involved in the removal of the amino group from cellular glycerophospholipids. 3-Bromo-4,5-dihydroxybenzonitrile binds to the hydrophobic pocket of DNA and prevents the formation of hydrogen bonds with the nucleobases. 3-Bromo-4,5-dihydroxybenzonitrile is a cochlear toxicant as it can cause hearing loss and deafness when administered at high doses. The cochlear toxicity may be due to its ability to inhibit tyrosine kinase activity, protein phosphatase 2</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 2,2-diMethylacetoacetate is a deuterated acetoacetate. It has a transition state that is oriented. This acetoacetate can be modified by modifiers such as transition metals and ligands. The methyl group can be removed from the molecule by hydrolysis or hydrogenation to form 2,3-dihydroxypropanoic acid.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Sodium carbonate is a white crystalline, water-soluble salt that is used in the manufacture of glass, textiles, paper, soap and detergents. It can be made by the reaction of sodium hydroxide and carbon dioxide at high temperature. The cyclopropylboronic acid (B) reacts with copper(II) chloride to form a carboxylate anion. The resulting compound reacts with dichloroethane to form the 2-cyclopropyl-2,3-dihydro-1H-isoindole-1,3-dione (A). This type of reaction is known as a nucleophilic substitution reaction.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Sodium thiophene-2-sulfinate is a synthetic reagent that can be used to form methylenecyclopropanes, which are highly reactive with respect to oxidizing agents. A radical coupling mechanism has been proposed for the reaction of sodium thiophene-2-sulfinate with peroxide, which proceeds through a chain mechanism. The functional groups on the molecule allow for selective reactions with anilines and other electrophiles. This reagent is also effective in the synthesis of type-2 diabetes drugs and for investigating mechanistic aspects of these reactions.

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4,4'-Carbonyldimorpholine is a thioxanthone that can be used in coatings and UV-curable inks. It is a cationic monomer that can polymerize with other monomers to form polymers with high molecular weight. 4,4'-Carbonyldimorpholine also reacts with fatty acids to produce water-soluble polymers and amines to produce water-insoluble polymers. This agent has been shown to interact with the surface of metals and acrylates, which are compounds that are used in coatings and UV-curable inks. The nature of this compound is dependent on the environment it is exposed to.</p>

<p>Versatile small molecule scaffold</p>

<p>2-(Naphthalen-2-yl)propan-1-ol is a chemical compound that has a chloride, fatty acid, carbonyl group, and an enantiomer. It can be used as an immobilizing agent for the preparation of enantiopure compounds. This compound is most commonly used as a reagent in organic chemistry to form reaction products with lipase and other enzymes. The reaction time varies depending on the enzyme used. 2-(Naphthalen-2-yl)propan-1-ol can also be activated by heating it with an acid or base to produce a different molecule.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Ethyl 3-hydroxypent-4-enoate is an enantiomer of crotylboration. It is a stepwise, chemoenzymatic, stereoselective synthesis of azide from chiral diols such as D-mannitol. This process involves the reaction of an alcohol with sodium azide in the presence of a base and solvent to give the corresponding hydrazone. The hydrazone reacts with crotylborane to form an epoxide with two adjacent hydroxy groups. This epoxide can then be reduced to an alcohol or oxidized to a ketone, both of which are valuable synthetic intermediates that can be used in organic chemistry. Ethyl 3-hydroxypent-4-enoate is also a synthetic intermediate for other compounds such as pharmaceutical drugs and agrochemicals.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

2-Amino-5-chloro-pyridine-3-sulfonic acid amide is a drug that has been shown to have cognition enhancing effects. It was found to be an inhibitor of the efflux transporter Pgp, which is expressed in pancreatic and intestinal cells. 2-Amino-5-chloro-pyridine-3-sulfonic acid amide also inhibits the activity of the enzyme ATPase, which is involved in energy metabolism. This drug has been shown to have vasodilator properties, making it useful for treating high blood pressure. It also has myorelaxant and muscle relaxant properties, making it useful for treating diseases such as Parkinson's disease. 2 aminopyridine sulfonamide also has pharmacological effects on the nervous system by inhibiting potassium channels and blocking synaptic transmission.

2-Amino-5-chloro-pyridine-3-sulfonyl chloride is an electrophilic compound that is a sulfonyl chlorides. This chemical has been used for the aerobic oxidation of amines, and it reacts with alkenes to produce enamines. 2-Amino-5-chloropyridine 3-sulfonyl chloride can be used as a starting material in the synthesis of other sulfonyl chlorides.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold