Building Blocks

<p>Benzothiadiazole-7-carboxylic acid (BTHCA) is an activated compound that has been shown to have potent bactericidal activity. It is a member of the benzothiadiazole family of compounds, which are found in the environment and have been detected in human blood. BTHCA inhibits the enzyme hydroxycinnamoyltransferase, which leads to a decrease in shikimate production and folate levels. BTHCA also reversibly inhibits methionine synthase, leading to an accumulation of homocysteine and methionine, which are toxic substances that lead to DNA damage and cell death. This compound has been used as a pesticide for plants by blocking plant protein synthesis. Analysis of BTHCA has shown it is metabolized into p-coumaric acid, which may be responsible for its observed anti-inflammatory effects.</p>

<p>Versatile small molecule scaffold</p>

<p>Chloromethyl propyl carbonate is a pyrimidine compound that has been proposed as a potential cancer drug. It has shown high resistance to the enzymes fatty acid synthase and tenofovir and has shown antiviral properties against HIV, herpes simplex, and hepatitis B. Chloromethyl propyl carbonate inhibits the production of acyclic nucleoside phosphonates. It also inhibits fatty acid synthesis by binding to the enzyme acyl-CoA synthetase 2. Chloromethyl propyl carbonate binds to nitrogen atoms in the active site of the enzyme glutamine synthetase, thereby inhibiting its activity. The pharmacokinetic properties of chloromethyl propyl carbonate have been studied in rats and dogs; it is absorbed orally with rapid distribution into tissues, including fat, liver, kidney, lung, and brain. The drug is metabolized by carboxyesterases in the liver and excreted in urine</p>

<p>1-Chloro-2,3-dihydro-1H-indene is a kinetic inhibitor. It has been shown to bind to the enzyme quinoline synthesis and to be reactive towards chloride ions. 1-Chloro-2,3-dihydro-1H-indene is used as an intermediate in the production of styrene. This monomer has high values for constant rate kinetics and exhibits a high affinity for chloride ions, which makes it a good candidate for use in polymerization reactions. The chlorine atom can be substituted with other atoms or groups, such as ethyl groups, halides, or transfer reactions. These derivatives are also known as quinoline derivatives.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,2-Dimethylcyclobutan-1-ol is an organic compound that belongs to the class of cyclopropanes. It is a stereospecific reaction product of 2,2-dimethylcyclopropanecarboxylic acid and sodium ethoxide in ethanol. This compound can be used as a chiral synthon for the synthesis of cyclopropane derivatives. The optical activity of this compound has been shown to be dependent on the configuration at the chiral center.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-(4-Bromophenyl)-5-oxovaleric acid is a molecule that has been synthesized to be used as a cancer drug. It is an amide derivative of the natural compound valproic acid and is being developed for the treatment of cancers, such as leukemia and melanoma. 5-(4-Bromophenyl)-5-oxovaleric acid has been shown to inhibit the function of integrin, which plays a role in cell adhesion and migration, with potential applications in wound healing. <br>The molecule has also been shown to have chemokine binding properties and may be useful in the treatment of diseases where chemokines are involved, such as HIV or AIDS. This compound also binds to CCR5 receptor and inhibits HIV entry into cells. The molecule has also been shown to antagonize survivin, an antiapoptotic protein that protects cells from undergoing apoptosis and prevents tumor suppression. The affinity of 5-(4-bromophenyl</p>

<p>3,5-Dichloro-2-hydroxybenzene-1-sulfonamide is a defoliant that was first developed in the 1950s. It is a desiccant that damages plants by blocking photosynthesis and causes leaf shedding. 3,5-Dichloro-2-hydroxybenzene-1-sulfonamide is used on cotton plants to control weeds and promote plant growth. This sulfonamide herbicide also has the ability to kill insects, such as potato beetles, which are harmful to crops.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Bromo-1-methoxypyrrolidin-2-one is a halogenated alkynyl compound that is used as an anti-inflammatory agent. It is a phenylcyclizing agent that reacts with an alkoxy group to form an alkyne and a cyclic ether. The cyclic ether then undergoes nucleophilic attack by an adjacent hydroxyl group, resulting in the formation of an oxetane ring. 3-Bromo-1-methoxypyrrolidin-2-one has been shown to have anti-inflammatory activities in mice and rats by inhibiting the production of inflammatory cytokines such as TNF, IL1β, and IL6.</p>

<p>3-Bromo-1-ethylpyrrolidin-2-one is an enantiomeric, immobilized lipase that is selective for the hydrolysis of cephalosporins. Unlike other immobilized lipases, this enzyme does not require a solvent or detergent to solubilize the substrate and allow it to react with the enzyme. The immobilization of 3-bromo-1-ethylpyrrolidin-2-one onto silica gel allows for the enantioselective synthesis of cephalosporins. This process is chemoenzymatic and is carried out without organic solvents, which increases its safety and environmental friendliness.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4,5-Diodoveratrole is a ligand that binds to tylophorine. It has been shown to be an interlinked molecule in electrochemical methods and can be detected by voltammetry. 4,5-Diodoveratrole has been used as a fluorescent sensor for methyl groups and is also able to cross-couple with methoxy groups. This molecule also forms functional groups on the devices of electrochemical biosensors.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-[3-(Trifluoromethyl)-1,2-oxazol-5-yl]acetamide is a fluorescence resonance energy transfer inhibitor that has been shown to be effective against the papillary muscle in rats. This drug has also been shown to inhibit the production of growth factors and cell proliferation in prostate cancer cells. N-[3-(Trifluoromethyl)-1,2-oxazol-5-yl]acetamide inhibits the enzyme kinase activity of protein tyrosine kinases, which are responsible for cell proliferation and differentiation. This drug is also an organometallic compound with low light fluorescence properties. It has been used as a radiation sensitizer to increase the effectiveness of radiation treatments for cancer.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>t-Butyl 2-iodobenzoate is a reagent that can be used to access cyclopentenes. The reaction begins with the lithiation of an alkoxycarbonyl group and the subsequent attachment of an electrophilic cyclopentene. The reaction is completed by adding a tertiary amine, which causes carbopalladation of the alkyl lithium intermediate, forming a new carbon-carbon bond. Cyclopentenes can also be accessed by intramolecular reactions using a palladium catalyst and alkoxycarbonyl groups as substrates. Camptothecin moieties are often functionalized with t-butyl 2-iodobenzoate in order to access camptothecin analogs.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Decahydrocyclohepta[C]pyrrole is a nitrogen-containing heterocycle that contains 5 hydrogen atoms and 10 carbon atoms. It has been shown to have modulatory effects on the 5-HT receptors, which are involved in the regulation of the nervous system. Decahydrocyclohepta[C]pyrrole binds to these receptors and inhibits their response to serotonin, a neurotransmitter that plays an important role in the modulation of mood, appetite, sleep, memory, learning, and temperature regulation. This drug has also been shown to have a protective effect against nerve cell damage induced by neurotoxins such as quinolinic acid or kainic acid.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>7-(Benzyloxy)-5-hydroxy-2-phenyl-4H-chromen-4-one is a modification of the natural product vinblastine. It has shown anticancer activity in human nasopharyngeal cancer cells, and is thought to be responsible for the antitumor effects of scutellariae extract. The modification is hypothesized to have taken place through nucleophilic attack by a hydroxide ion on the benzyl alcohol group on the 7 position. This mechanism would lead to the formation of an epoxide intermediate, which would then react with another molecule of 7-(benzyloxy)-5-hydroxy-2-phenyl-4H-chromen-4 one to form an acetate ester and a molecule of water.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>2-(Cyclohexylmethyl)butanoic Acid is a mu-opioid receptor agonist that binds to the opioid receptor. It has been shown to have a solid form, which can be administered orally or intravenously. 2-(Cyclohexylmethyl)butanoic Acid is used in the treatment of acute and chronic pain, as well as post-operative bowel dysfunction. It has an antagonistic effect on the opioid receptors, which prevents it from inducing opioid-induced bowel dysfunction. The hydrochloride salt of this drug is available for oral administration.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>