Building Blocks

<p>2,6-Dimethyl-4-nitroaniline (DMN) is a nitrosamine that has been found to be a significant contaminant of drinking water. DMN is regulated as an irritant and a probable human carcinogen. The effects of DMN on the body are not fully understood, but it has been shown to cause damage to the liver and kidney in vivo. DMN may act by interfering with the synthesis of DNA or RNA, which can lead to cell death. The proposed mechanism for this is inhibition of the enzyme ribonucleotide reductase, which converts ribonucleotides into deoxyribonucleotides for DNA synthesis. This mechanism is supported by experiments in rats where DMN was found to inhibit erythrocyte production in vivo.<br>DMN can also be methylated in vivo by S-adenosylmethionine synthetase, yielding 2-methyl-6-dimethylamino-4</p>

<p>Ethyl 4-aminonicotinate is a cyclic amine with a chemical formula of C6H11NO2. It has a molecular weight of 117.07 g/mol, and its molecular structure consists of an ethyl group attached to the amino group. The molecule has three resonance peaks in the infrared spectrum at 2,617cm-1 (ν(C=O)), 1,906cm-1 ((C=N)), and 1,723 cm-1 (ν(NH)). In addition to these peaks, the molecule also has two magnetic resonance peaks at 2.24ppm (δ) and 3.38ppm (δ). This compound is soluble in water and can be used as an intermediate in organic synthesis or pharmaceuticals.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Methyl-1,3-benzothiazol-2-amine is a molecule that belongs to the class of isothiocyanates. It can be synthesized by reacting 2-chlorobenzothiazole with primary amines in the presence of a nonpolar solvent. This method is efficient and can provide high yields for this molecule. N-Methyl-1,3-benzothiazol-2-amine has been shown to inhibit the uptake of pesticides by plants. The mechanism is not well understood but it may involve vibrational interactions with molecules in the plant cell membrane or chemical interactions with other molecules in the plant cell. This molecule also has nitrogen atoms and mass spectrometric techniques have shown that it has an nmr spectrum.</p>

<p>Versatile small molecule scaffold</p>

<p>3-Amino-1-benzylurea is a compound that is used as a reagent in organic chemistry. It is an important starting material for the synthesis of semicarbazides, acetals, and orthoesters. 3-Amino-1-benzylurea can be synthesized from triethyl orthoformate, triethyl orthosilicate, or hexamethyldisilazane. The synthesis proceeds by reacting 3 equivalents of triethyl orthoformate with one equivalent of benzyl chloride to form the corresponding urea. This urea is then hydrolyzed to give the desired product.</p>

<p>2-Methyl-2-pentenoic acid (MP) is a synthetic product that is used as a chemical intermediate in the production of pesticides and pharmaceuticals. It can be found in the environment due to its use as an organic solvent, metal surface cleaner, or insecticide. MP has been shown to have mosquito repellent properties and has been used as an additive in some mosquito coils. This compound also has anti-inflammatory effects and can be used as a dietary supplement. The synthesis of MP involves the reaction of cinchonidine with ethyl acetate, which proceeds through an addition reaction mechanism. The reaction rate is dependent on the presence of nucleophiles such as water or methanol, but not alcohols or hydrogen peroxide.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl indolizine-2-carboxylate is a synthesized chemical that belongs to the class of amides and has been shown to have hypoglycemic activity in mice. This compound was synthesized by alkylation of dodecyl with acrylonitrile followed by hydrolysis. Mechanistic studies show that methyl indolizine-2-carboxylate binds to amines, which are an important part of the insulin receptor binding site, and inhibits the kinetics of insulin action. Methyl indolizine-2-carboxylate can also inhibit the synthesis of nitric oxide (NO) at high concentrations. The chemical's affinity for NO is stronger than its affinity for amines, but it has not been shown to inhibit the kinetics of NO production.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Benzene-1,4-disulfonamide is a vasodilator that is soluble in water. It has a heterocyclic ring with a nitrogen atom, a chloride group and cyclic nitro groups. The solubility of benzene-1,4-disulfonamide in water makes it suitable for intravenous administration. It also has an effect on the cerebral vasculature and can be used as a vasodilator. Benzene-1,4-disulfonamide is structurally related to sulphonamides and has similar properties to these drugs.</p>

<p>Azd1283 is a potent antagonist of the P2Y12 receptor. It inhibits the proliferation of mammalian cells and has been shown to be effective against hyperproliferative disorders such as cancer. Azd1283 is a quinoline derivative that is supplied as an organic solvent. It binds to the P2Y12 receptor on the cell surface and prevents activation, leading to inhibition of the downstream signalling pathways.</p>

<p>3-Azabicyclo[3.2.1]octan-2-one is an alkenoic, undescribed chemical with a basic structure that includes two oxime groups and a lactam ring. It is used as a photolysis reagent for the conversion of primary amines to secondary amines and vice versa in the presence of methyl groups. Its photochemistry has been studied extensively, including its photoinduced reaction with amides to form isomeric amines and its photoinduced reactions with lactams to form isomeric lactams. 3-Azabicyclo[3.2.1]octan-2-one reacts with primary amines to form secondary amines, which can be converted back into the original primary amine by heating or by treatment with acid or base. The conversion of primary amines to secondary amines may be accomplished through the use of 3-azabicyclo[3.2.1]</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Spiro[4.5]decan-8-ol is a terpene that has shown to be an anti-cancer agent. It inhibits the population growth of solid tumours in animal models and inhibits the proliferation of human cancer cells by inducing apoptosis. Spiro[4.5]decan-8-ol also has anti-inflammatory effects, which may be due to its ability to inhibit the production of proinflammatory cytokines such as tumor necrosis factor alpha (TNFα) and interleukin 1β (IL1β). Spiro[4.5]decan-8-ol also has been shown to inhibit HIV infection, as well as autoimmune diseases and other infectious diseases, by binding to human proteins involved in transcriptional regulation and gene expression.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Methoxy-1H-indazole-3-carboxylic acid amide is a glycogen synthase kinase 3 (GSK3) inhibitor. GSK3 is a serine/threonine protein kinase that regulates glycogen synthase and phosphorylates tau proteins. 5-Methoxy-1H-indazole-3-carboxylic acid amide has been used in the treatment of type 2 diabetes mellitus, Alzheimer's disease and other neurological disorders. The cocrystal structure of 5-methoxy indazole carboxamide with glycogen synthase was determined at 1.2 Å resolution.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Amino-1-benzyl-1H-pyrazole-4-carbonitrile is a receptor antagonist that belongs to the group of diazonium salts. It has been shown to bind selectively to high levels of purine receptors in the heart, lungs, and kidneys. This drug has also been shown to be an effective inhibitor of smooth muscle cell proliferation, which can reduce the risk of pulmonary hypertension. 5-Amino-1-benzyl-1H-pyrazole-4-carbonitrile has been synthesized and tested for clinical studies. The compound has shown potency against diazotization reactions with biological activity.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Acetyl-4-hydroxy-3,6-dihydro-2H-1,3-thiazine-2,6-dione is a phenolate which has been shown to have antibacterial activity. It binds to the thiol group of the enzyme hepg2 and inhibits its activity. This leads to a decrease in cell growth and eventually cell death. 5-Acetyl-4-hydroxy-3,6-dihydro-2H-1,3-thiazine - 2,6 - dione has been found to be effective against strains of Staphylococcus and other bacteria that are resistant to penicillin. 5ADHTD has also been shown to have kinetic and thermodynamic properties that make it a good candidate for use as an antibiotic.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>