Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>((Cyclopent-3-en-1-yloxy)methyl)benzene (CPMB) is a cyclopentanoid that is found in nature. It has a hydrophilic substituent on the 3rd carbon and a hydroxyl group on the 1st carbon. The substitution at the 3rd carbon is an unresolved stereoisomer. CPMB is also a natural product that can be found in mixtures with other compounds. It can be synthesized using cyclopentadiene and connect to form a ring, or it can be created by reacting oxygen atoms from hydrogen peroxide with benzene. CPMB has been studied for its biological effects such as inducing sleep, or its potential use in cancer treatments.</p>

<p>Versatile small molecule scaffold</p>

<p>1-(3-Methoxyphenyl)thiourea (1-MTU) is a drug that has been shown to have hypoglycemic activity in animal models of diabetes. It is an agonist for the human glucagon receptor and has EC50 values of 0.3-0.8 μM, which are similar to those of the natural ligand, glucagon. 1-MTU has been shown to be effective in reducing hyperglycemia in diabetic mice and rats. This drug is being considered as a potential treatment for type 2 diabetes and may be useful for treating other diseases with an inflammatory component such as arthritis and osteoporosis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Chloro-1-methyl-1H-imidazole-2-carbaldehyde is a flavonoid that is chemically synthesized and structurally related to the isoxazoles. It has been shown to have an activating effect on nonselective cation channels and pharmacokinetic properties in rats. The drug has also been shown to inhibit intestinal motility by increasing the intracellular calcium levels in rat colonic smooth muscle cells. 5-Chloro-1-methyl-1H-imidazole-2-carbaldehyde may be useful for the treatment of gastrointestinal disorders, such as constipation and irritable bowel syndrome, due to its ability to relax muscle contractions in the intestines.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Potassium hydroquinone monosulfate (KHQMS) is a chemical substance that is used as a co-precipitant in the preparation of samples for analysis by high-performance liquid chromatography. It has hydroxyl groups on both ends and can be used to filter organic particles from water samples. The KHQMS can also be used for the removal of substances that interfere with analytical measurements, such as polysaccharides, polymers, proteins, lipids, and other organic molecules. This compound can be recycled and reused up to four times. It has been found to be effective in the extraction of phenolic compounds from leaves and granules. KHQMS is also used in bioanalytical methods for the determination of human urine samples.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Amino-4H,5H-naphtho[2,1-b]thiophene-1-carbonitrile is a dihydronaphthalene compound that has been shown to be active against influenza viruses. It inhibits the virus by binding to the pyrimidine ring of the virus's RNA polymerase. This inhibits viral replication and reduces plaque formation. 2-Amino-4H,5H-naphtho[2,1-b]thiophene-1-carbonitrile has antiviral activity against influenza A and is effective in inhibiting h5n1 virus replication.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methylphthalic Acid is a chemical that is used in the production of polyvinyl chloride. It is produced by the dioxygenation of phthalic anhydride and methanol, which produces 3-methylphthalic acid as well as 1,1-dichloroethane. The chemical can be used as a surfactant in polyvinyl chloride and styrene production processes. 3-Methylphthalic Acid has been shown to have adverse health effects on laboratory animals, including polyvinyl chloride workers who are exposed to it for prolonged periods of time. The chemical can cause irritation and corrosion to skin and eyes, as well as damage to the liver and kidneys.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(2-Bromo-ethoxy)-3,5-dimethyl-benzene is a potential drug that has immunosuppressive effects. It binds to the pyrimidine ring of human immunodeficiency virus (HIV) and inhibits its activity. This inhibitor blocks the synthesis of viral DNA and RNA by binding to the sulfur atom of the pyrimidine ring. The substituents on this molecule are bromine and ethoxy groups, which are alkylated.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Hydoxyquinoline-2-carboxamide is a molecule that belongs to the hydroxamic acid class. It is a zirconium-containing derivative of hydroxylamine and, as such, is tautomeric with respect to the carboxylic acid moiety. This compound has been shown to be mutagenic in Salmonella typhimurium strains TA98 and TA100 and in Escherichia coli strain WP2 uvrA. N-Hydroxyquinoline-2-carboxamide has also been found to be an inducer of sulfation and conjugates with glutathione and other organic acids.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-(2-Hydroxy-2-methylpropyl)acetamide (HMPA) is a molecule inhibitor that inhibits the activity of inflammatory bowel disease (IBD)-associated kinases. HMPA is a member of a family of molecules that are inhibitors of IBD-associated kinases, which may be useful for the treatment of IBD. HMPA has shown in vitro inhibition against two kinases, JNK1 and p38 MAPK, which are both important mediators in the progression of IBD. This drug may be used to inhibit inflammation in the digestive tract by blocking these inflammatory pathways.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Ethoxy-1,3,4-thiadiazole-2-thiol is a heterocyclic compound that belongs to the group of thiadiazole dimers. It has a planar structure and is composed of two five-membered heterocycles that are connected by a single bond. The molecule contains no hydrogen bonds and has a dihedral angle of about 60°.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Phenacylamine hydrobromide is an alkylsulfonyl carbonyl compound that has a nitro group. It is used as a plant growth regulator for horticultural purposes, and inhibits the production of dopamine and serotonin in the brain by binding to monoamine oxidase. Phenacylamine hydrobromide also has been found to be effective in treating autoimmune diseases through its ability to inhibit the production of interferon-γ. The conformational properties of phenacylamine hydrobromide are affected by the presence of deuterium, which results in an increased rate of reaction with hydroxyl groups as well as a decrease in reactivity with nitro groups.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,3-Dihydro-1H-indene-2-carbaldehyde is a bioisostere of the aromatic compound 2,3-dihydrobenzo[b]thiophene. It has been shown to be potent and selective antagonists of the rhodium complex that binds to the topoisomerase I enzyme found in bacteria. The carbonyl group on this molecule is in an active conformation, which makes it a good inhibitor for topoisomerase 1.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>6-Chloro-3,4-dihydro-1,2,3-benzotriazin-4-one is a potent anti-inflammatory agent that belongs to the group of organic compounds. It has been shown to be more effective in inhibiting inflammation than other classes of drugs such as nonsteroidal anti-inflammatory agents. 6-Chloro-3,4-dihydro-1,2,3-benzotriazin-4-one also blocks the production of prostaglandins by inhibiting cyclooxygenase and lipoxygenases. This drug is not a nitrite but is converted into one by sodium nitrite in a reaction that releases nitric oxide. Nitric oxide causes vasodilation and inhibits platelet aggregation, which reduces blood clot formation.</p>

<p>Versatile small molecule scaffold</p>

<p>1,3-Dimethyl 2-phenylpropanedioate is a molecule that is used in the production of malonic acid. The reaction mechanism involves an enzymatic homogenization of the reactants, which leads to the formation of carbonyl oxygens and reaction intermediates. The carbonyl oxygens are then protonated by ethyl diazoacetate to form allyl carbonates. This process occurs in the presence of immobilized enzymes and chemical reactions.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1,2-Thiazinane-1,1-dione is a short-chain alkylating agent that has been shown to have neuropathic and inflammatory pain relief. It binds to a number of halides and inhibits their action, including the inhibition of angiotensin I-converting enzyme (ACE), which is an antihypertensive agent. 1,2-Thiazinane-1,1-dione also inhibits the production of epoxides in c1-4 alkyl groups. This drug also has antibacterial properties and can be used as a chemical probe for ligand binding studies.</p>

<p>Versatile small molecule scaffold</p>

<p>1-Phenylbut-3-en-2-one is an n-oxide that is the product of the reaction between 2,4,6-trinitrobenzenesulfonic acid and phenylacetic acid. It has been used as a horticultural agent for controlling mildew on plants. It has also been shown to have a potent inhibitory effect against cell growth in vitro at doses of 50 μmol/L. 1-Phenylbut-3-en-2-one will react with chlorine atoms in the environment to form chlorinated derivatives that may be more toxic than the parent compound. 1Phenylbut-3-en-2-one has neuroprotective properties and has been shown to reduce the incidence of cancer in rats by inhibiting carcinogenesis studies. This drug also exhibits antiangiogenic properties, which may be due to its inhibition of DNA synthesis and protein synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>1H-Pyrrole-2-carbothioamide is an analog of porphyrin. It has a macrocyclic structure with a central metal atom that is bonded to four sulfur atoms and two nitrogen atoms. It absorbs light in the visible region, which makes it appealing for use as a pigment or dye. 1H-Pyrrole-2-carbothioamide has been shown to be biocompatible with living cells and tissues, making it suitable for use in biomedical applications. This molecule can be synthesized by reacting potassium with methanesulfonic acid followed by addition of thiocyanate ion.</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 1-methyl-1H-indole-2-carboxylate is an organic compound that belongs to the family of indole carboxylic acid esters. It is an x-ray crystallographic study for the preparation process, and it has been shown to have antileishmanial activity. The methyl ester is a reagent for the synthesis of octahydroaziridine and can be used as a reagent in Grignard reactions.</p>