Building Blocks

<p>1,8-Naphthyridine-2(1H)-one is a naphthyridone that inhibits the growth of gram-positive bacteria. This compound binds to the CB2 receptor site on the cell membrane and blocks the transfer of electrons from cytochrome c to molecular oxygen, which inhibits the production of reactive oxygen species. This inhibition causes an accumulation of hydrogen peroxide in the bacterial cell and leads to necrosis. 1,8-Naphthyridine-2(1H)-one has also been shown to inhibit HIV infection by inhibiting reverse transcriptase activity through metal chelate formation.</p>

<p>2-Chloro-1,8-naphthyridine is a configurational isomer of 1,8-naphthyridine. It has two phenyl groups and a cyclic configuration. 2-Chloro-1,8-naphthyridine is synthesized from 2,6-dichloronaphthalene by oxidation with potassium permanganate and subsequent reduction with iron powder. The compound can reversibly form metal complexes with potassium. 2-Chloro-1,8-naphthyridine exhibits reversible changes in its conductance when subjected to cyclic voltammetry.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Bromo-7-methyl-1H-indole is a serotonin receptor antagonist that blocks the binding of serotonin to its receptors, which are located on nerve cells. This drug has been used in animal studies to study the role of serotonin in brain function. 5-Bromo-7-methyl-1H-indole has also been shown to be an effective antiserotonin agent for the treatment of depression and anxiety.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>7-Chloro-1,8-naphthyridin-2-ol is a nucleic acid that stabilizes duplexes and triplexes. It has an affinity for adenine bases in DNA, RNA, or triplexes. 7-Chloro-1,8-naphthyridin-2-ol also binds to mismatched nucleobases in the sequence of nucleic acids. This compound is a potent inhibitor of HIV replication and has been shown to inhibit the growth of cancer cells by targeting the enzyme topoisomerase II alpha.</p>

<p>2-Chloro-5-(methylsulfanyl)aniline is a sulfoxide that can inhibit the n-methyl-d-aspartate (NMDA) receptor, which is an ion channel that plays a key role in neuronal excitability. 2-Chloro-5-(methylsulfanyl)aniline has been shown to be neuroprotective against glutamate toxicity in rats and mice. This drug also blocks the NMDA receptor by binding to it, preventing glutamate from activating it. 2-Chloro-5-(methylsulfanyl)aniline has been shown to have neuroprotective effects in animal models of stroke, cerebral ischemia, and traumatic brain injury.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,3,4-Trichlorophenol (2,3,4-TCP) is a water-soluble compound that is used as an analytical reagent. 2,3,4-TCP is also an antimicrobial agent found in household cleaners and disinfectants. It is used to remove bacteria from equipment and surfaces in hospitals and other healthcare facilities. The acidic aqueous solution of 2,3,4-TCP has been shown to adsorb triclosan and p-hydroxybenzoic acid from wastewater treatment systems. The reaction mechanism for the adsorption process is not well understood but may involve the formation of hydrogen bonds between the polar hydroxyl groups on 2,3,4-TCP and the carboxyl groups on triclosan or p-hydroxybenzoic acid. Anhydrous sodium can be used as an alternative to water for this process.</p>

<p>Versatile small molecule scaffold</p>

<p>3-(4-Fluorophenyl)butanoic acid is an analog of butanoic acid. It has been shown to have properties similar to carbamates and to be an intermediate in the synthesis of a number of other compounds. 3-(4-Fluorophenyl)butanoic acid is used as an oral dosage form, which is converted into its active form (2-chloro-N-[3-(4-fluorophenyl)propionyl]acetamide). This drug has been shown to be effective for the treatment of reflux disease, with a lower incidence of side effects than some other drugs used for this purpose.</p>

<p>1-(1,4-Dioxan-2-yl)ethan-1-one is a nucleophilic compound that can be used as a catalyst for the conversion of carbinols and ketonitriles to their corresponding esters. It has been shown to have stereoselective properties in its reaction with substituted phenols. 1-(1,4-Dioxan-2-yl)ethan-1-one is also able to form coordination complexes with metals. The molecule is chiral and the enantiomers have different reactivities. This product has been shown to be useful in coatings, such as those applied to paper or textiles.</p>

<p>N-(4-Hydroxyphenyl)-3,4,5-trimethoxybenzamide is a biomolecule that is found in nature. It has a square shape and is hydrophobic. The molecule consists of an amide group and a benzene ring. The molecule has been shown to have dose-dependent effects on ligands. Nonpolar molecules are attracted by the hydrophobic interactions between the benzene ring and the amide group. This molecule has also been cocrystallized with a nonpolar ligand. In this conformation, it is an anionic species with a dihedral angle of 90 degrees.</p>

<p>Sodium 4-nitrobenzenesulfinate is a sulfonylating agent that is used in organic chemistry to synthesize dihydronaphthalene, which is an intermediate in the synthesis of naphthalenes. It can be prepared by the ring-opening reaction of sodium nitrobenzenesulfinate with a suitable nucleophile such as methylenecyclopropanes. Sodium 4-nitrobenzenesulfinate reacts with sulfur to form sulfones, which are important intermediates for the synthesis of thiazoles and benzothiazoles. This reagent has been shown to be effective for the synthesis of biomolecules, such as proteins and peptides.</p>

<p>N-Phenylaminosulfonamide is a prodrug that is metabolized in the body to release oxadiazole. It has been shown to lower intracellular calcium levels by targeting response elements and hydrogen bonds in the cell. N-Phenylaminosulfonamide also inhibits fatty acid synthesis, which may be due to its ability to inhibit 3t3-l1 preadipocytes. The drug has been shown to have an anti-obesity effect by inhibiting energy metabolism through inhibition of hydroxyl group oxidation, leading to reduced glucose uptake and glycolysis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 3-methylenecyclobutanecarboxylate is an organic compound with the chemical formula CH3C(O)CH2CH2COOCH3. It is a colorless liquid that is soluble in organic solvents. Methyl 3-methylenecyclobutanecarboxylate has been studied for its use as a precursor to potassium salts, which are used as catalysts in industrial processes. Methyl 3-methylenecyclobutanecarboxylate has also been identified as a structural factor for the elimination of potassium from cyclopentanone and benzene, factors that contribute to its elimination from the body. This compound can be brominated using potassium tert-butoxide and reactions with other reagents such as lithium chloride or sodium hydroxide to form methyl 3-bromocyclobutanecarboxylate, which can then be dehydrobrominated to form methyl 3-</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 4-hydroxy-3-methoxyphenylacetate (HMPAA) is a natural compound, which can be detected by mass spectrometric detection. It is an evaporative and has been shown to have inhibitory effects on the growth of ganglion cells in culture. HMPAA also inhibits phosphotungstic acid precipitation assays and crth2 expression. HMPAA has been shown to interact with other proteins, such as protein–protein interactions or functional groups. This compound is also involved in chemical reactions, such as the hydroxyl group or the methyl group. The detectable concentration of HMPAA ranges from 1 ng/mL to 1 μM and it is found in monomers or organic acids.</p>

<p>1-Methyl-4-phenyl-1H-1,2,3-triazole is a ligand that interacts with copper. It is used in the synthesis of pyridine complexes and as a reagent for the preparation of other organometallic compounds. 1-Methyl-4-phenyl-1H-1,2,3-triazole has been shown to be able to replace azide or chloride ligands in some metal coordination complexes. It has been observed in spectra of copper and rhenium complexes with axially coordinated ligands. The X ray crystal structures of 1 methyl 4 phenyl 1H 1 2 3 triazole have revealed that it can be either a luminescent or nonluminescent compound depending on the type of solvent used during its preparation.</p>

<p>2-Chloro-4-methyl-1H-benzo[d]imidazole is a biochemical, which has been used in structural studies and conformational analyses. The compound has been shown to be an oriented molecule that can exist in two different forms, depending on the solvent conditions. 2-Chloro-4-methyl-1H-benzo[d]imidazole is a halide with a low degree of solubility in water. It reacts with divalent cations such as magnesium or calcium ions to form insoluble salts. 2CMBDI has been shown to inhibit DNA replication by binding to 8-oxoguanosine residues during the synthesis of DNA and preventing their incorporation into the growing strand. Mechanistically, 2CMBDI inhibits cellular anions and causes cell death by inhibiting DNA replication.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Amino-5-methyl-4-pyrimidinol is a metabolite of the nucleobase cytosine. It is also a competitive inhibitor of guanine deaminase, an enzyme that converts guanine to inosine. 2-Amino-5-methyl-4-pyrimidinol can be synthesized by solid phase synthesis and has been shown to have clinical potential for the treatment of cancer.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Propylpiperidine hydrochloride is a piperidine that is heterocyclic in nature and has the molecular formula C8H19N. It is obtained by the condensation of propionic acid with ammonia, followed by reaction with ethylene oxide. 2-Propylpiperidine hydrochloride is used as a starting material in the synthesis of other compounds such as coniine and its derivatives. The stereogenic center in 2-propylpiperidine hydrochloride can be synthesized using asymmetric methodology. The salt form of this compound is 2-propylpiperidine hydrochloride hydroxide (2-ppi) or 2-propylpiperidine hydrochloride hydrate. This compound can also exist as an alcohol, enantiopure, or amide form.</p>

<p>Versatile small molecule scaffold</p>

<p>3,6-Methylene-2,5-piperazinedione is a heterocyclic compound that belongs to the piperazinedione ring system. It is synthesized from 3,6-dithiobenzoic acid and thioacetic acid. The synthesis of this compound proceeds through a series of reactions involving oxidation of the thioacetic acid to the dithiols, followed by a sequence of nucleophilic substitution reactions.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Cyanopyridine-2-carboxylic acid is a chemical compound that has the molecular formula of CHNO. It is soluble in water, alcohols, and ethers. This compound is a nucleophile and reacts with electrophiles such as amides and nitriles to form carboxylic acids. The selectivity of this reaction depends on the steric effects of the reactants. 4-Cyanopyridine-2-carboxylic acid can be used as a catalyst for carboxylation reactions, which are catalytic reactions involving the addition of hydrogen and hydroxide ions to a carbonyl group to form an ester or an amide. 4-Cyanopyridine-2-carboxylic acid also has been shown to be effective in neutralizing nitrile groups in organic synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-(Pyridin-2-yl)prop-2-enamide is a synthetic compound that reacts with ethylene to form a fluorescent copolymer. It is activated by radiation and has a high quantum yield of fluorescence, which makes it useful for the detection of ethylene in the environment. N-(Pyridin-2-yl)prop-2-enamide has also been shown to have hydrophobic properties and can bind to biotin. This compound is an excellent monomer for supramolecular polymerization and can be used for the synthesis of polymers with interesting optical properties.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-(Methylsulfanyl)-1H-indole is a heterocyclic compound that contains a methylsulfanyl group. It is an orally active oxidant and thermally reactive molecule with a carbazole-like structure. 3-(Methylsulfanyl)-1H-indole undergoes oxidation in the presence of chloride ions to form sulfoxide, which can be reversibly converted back to the original compound by addition of hydrogen sulfide. The hypervalent character of this compound makes it switchable between two different oxidation states. 3-(Methylsulfanyl)-1H-indole has been shown to react with sulfoxides, such as dibenzothiophene-4,5-dithiol, to form products in which the sulfur atom is present in high oxidation states.</p>

<p>Versatile small molecule scaffold</p>

<p>2-(Aminomethyl)cyclohexan-1-amine is a synthetic compound that belongs to the group of phenethylamines. It has been shown to inhibit the growth of L1210, a murine leukemia cell line, and also shows cytotoxic effects on the HL-60 human leukemia cell line. It has shown an ability to chelate ring structures such as flavin and mononucleotide. The 2-(aminomethyl)cyclohexan-1-amine molecule can be converted into two isomers, namely 2-(aminomethyl)cyclohexanol and 2-(aminomethyl)cyclohexanone.<br>2-(Aminomethyl)cyclohexanol is a synthetic compound that belongs to the group of phenethylamines. It has been shown to inhibit the growth of L1210, a murine leukemia cell line, and also shows cytotoxic effects on the HL-60 human</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Biphenyl-4-amidoxime is a hepatoprotective drug, which helps to protect the liver from damage. It has been shown to be effective against hepatomegaly, or enlarged livers, in vivo experiments and can be used for the prevention of liver toxicity caused by antibiotics such as spiramycin and mycophenolic acid. Biphenyl-4-amidoxime inhibits the production of malondialdehyde (MDA) in the liver, which is a marker for lipid peroxidation. It also decreases the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), which are indicators of liver injury. This agent has an inhibitory effect on Toxoplasma gondii and has been shown to have selectivity index &gt; 500 in vitro.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>