Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>(2-Aminoethyl)(decyl)amine is an orthogonal and metallic amino acid that can be used as a ligand for monolayer formation. This amino acid is synthesized from the reaction of 2-aminopropane and decanol, which are both readily available in industry. The unique properties of (2-aminoethyl)(decyl)amine make it an ideal candidate for use in tailored nanoparticles to form a monolayer.</p>

Versatile small molecule scaffold

<p>3-Methoxybenzenepropanol is an organic compound that belongs to the group of hydrocarbons. It is made by reacting allylsilane with chloride in a hydroboration reaction to form a single-crystal x-ray analysis. 3-Methoxybenzenepropanol has been shown to react with cyclopropanes, forming intramolecular cyclopropanation and ring-opening reactions to yield x-ray products. This product has also been used as a precursor for the synthesis of tetralin and biomolecules.</p>

<p>Versatile small molecule scaffold</p>

<p>Ethyl 3-hydroxy-1H-pyrazole-4-carboxylate is a hypoglycemic agent that binds to the ATP receptor in the body. It has been shown to reduce blood sugar levels in diabetic mice and has also been used to treat cancer. Ethyl 3-hydroxy-1H-pyrazole-4-carboxylate is an amide with a hydrogen bond, which may be responsible for its ability to bind to the ATP receptor. This drug is not effective against bladder, hepatitis, or nervous system diseases. Ethyl 3-hydoxy-1H-pyrazole-4-carboxylate is effective against neurodermatitis and inflammatory diseases, but only at high doses.</p>

<p>2-Amino-4-chloromethylthiazole (2ACMT) has been shown to be an effective antifilarial agent in pyridinium, acanthocheilonema, and refluxed mice. 2ACMT is a nucleophilic compound that binds to the active site of the enzyme DNA gyrase, inhibiting DNA synthesis. This drug also has antibacterial activity, which may be due to its ability to inhibit protein synthesis in bacteria.</p>

<p>5,5-Dicyclopropylimidazolidine-2,4-dione is an ammonium salt that has a strong antispasmodic effect. It is used to treat muscle spasms and other types of spasticity. 5,5-Dicyclopropylimidazolidine-2,4-dione also has an alkali metal (e.g., sodium) or alkali earth metal (e.g., magnesium) salt form that can be used for the treatment of cystitis, pyelonephritis, and other urinary tract infections. This compound is converted to the corresponding hydantoin derivative in vivo by hydrolysis of the ethoxide group. Hydantoins are related to the hydantoin class of nonsteroidal anti-inflammatory drugs (NSAIDs).</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Nitro-4-propoxybenzene is a covalent inhibitor of aspartic acid proteases. It is an aspartic acid analog that competes with the natural substrate for the active site and inhibits the transpeptidation reaction. This compound has been shown to be highly selective against renin, which is a key enzyme in the blood coagulation cascade. The 1-nitro group can be replaced by other groups to modulate potency or selectivity. These modifications may also improve water solubility, stability, or bioavailability.</p>

<p>4-Nitrophenyl N,N-dimethylcarbamate is an enzyme that catalyses the chemical reaction: anions + NADPH → nitrite + NADP. The enzyme can be inactivated by chloral and aldehyde dehydrogenase. It is labile in the cytosol but stable when bound to follicle cells. 4-Nitrophenyl N,N-dimethylcarbamate has been used to measure the activity of this enzyme in follicle cells, which are found in the ovaries and testes. The protein is active only when it binds to follicle cells.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Oxaspiro[4.5]decan-3-one is a chemical that is structurally related to the neurotransmitter gamma-aminobutyric acid (GABA). It has been shown to be an effective treatment for chronic pain, with a relatively low incidence of adverse effects. 2-Oxaspiro[4.5]decan-3-one inhibits the activity of protein kinase C, which may contribute to its analgesic effect. GABA receptors are present in the detrusor muscle and urethral sphincter, which may explain some of the drug's efficacy. 2-Oxaspiro[4.5]decan-3-one also binds to gabapentin binding sites on the alpha2 delta subunit of voltage dependent calcium channels and inhibits Ca2+ entry into cells, thereby reducing intracellular Ca2+ levels and lowering the excitability of neurons.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>4-Amino-2-bromopyridine-3-carbonitrile is an allosteric modulator of the metabotropic glutamate receptor (mGluR). It has been shown to have a pharmacokinetic profile that is suitable for oral treatment. The compound was synthesized and tested in the laboratory, where it showed efficacy on a number of different animal models.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

2-Sulfanyl-1,3-benzoxazole-6-carbonitrile (SBX) is a chemical compound that can be used to form microspheres. SBX has been shown to bind to caffeine and theophylline, which are drugs used in the treatment of certain disorders. SBX can be imprinted with a drug molecule or other biologically active molecule, such as DNA or proteins. This process allows for controlled release of the drug over time. The imprinted molecules are electrochemically detectable using an electrochemical biosensor device. SBX has also been used in polymerized and immobilized methods in order to extract myoglobin from human serum samples.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>6-Cyano-2-methylpyridine-3-carboxylic acid is a polymerizable, biodegradable and non-toxic monomer that belongs to the class of phenylacetic acids. It has been shown to have constant properties in microspheres and can be used as a matrix for caffeine profiling. This drug has been shown to be stable in human serum and various techniques have been developed to measure its activity against infectious diseases such as myoglobin and erythrocyte lysis. 6-Cyano-2-methylpyridine-3-carboxylic acid has also been shown to be influential on theophylline metabolism, which is an important drug for treating asthma. The high selectivity of this compound may be due to its ability to bind covalently with proteins, lipids, or other molecules present in the sample preparation process.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate is a synthetic intermediate that is used to access cyclobutanes, tert-butyl, azetidines, and piperidines. It has been shown to be an efficient and scalable bifunctional reagent for the synthesis of these compounds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>