Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Chloro-4-nitroisoquinoline is an antagonist of the alpha2-adrenergic receptor. It binds to the receptor and blocks the binding of agonists such as clonidine, causing a decrease in lipolysis and vasoconstriction. This agent has been shown to have a low affinity for other receptors, such as dopamine, histamine, serotonin, acetylcholine, and opioid receptors. 1-Chloro-4-nitroisoquinoline has been used to treat hypertension, Raynaud's phenomenon (a disorder that causes reduced blood flow to the fingers or toes), and benign prostatic hypertrophy (enlargement of the prostate).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(4-Methoxyphenyl)malondialdehyde is a synthetic chemical that is used as a reagent for the synthesis of piperidine derivatives. It can be readily prepared using hydrogen chloride and a hydrocarbon solvent in the presence of an acid catalyst. 2-(4-Methoxyphenyl)malondialdehyde has been used in the synthesis of bone morphogenetic proteins and other molecules, such as dorsomorphin and ldn-193189.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Iodopyridazine is a trifunctional molecule that has been used as a luminophor. It can be synthesized by palladium-catalyzed cross-coupling of 3-bromopyridazine with diethyl ester, yielding the desired product. This product is an organic solvent that contains nitrogen atoms and exhibits enhanced fluorescent properties. The supramolecular chemistry of this compound has been studied extensively, and it has been shown to have nucleophilic functionalities, which make it useful in cross-coupling reactions.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-5,6,7,8-tetrahydroquinoline-3-carbonitrile is an anhydrous organic compound that is used as a starting material for the synthesis of pharmaceuticals. It is prepared by the reaction of anhydrous ethanol with benzoyl chloride and hydrogen chloride in the presence of a catalyst. The product has been shown to be stable at room temperature.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Tert-butyl pyridine-3-carboxylate is a synthetic precursor to the anti-HIV drug, 3,4-dihydro-2(1H)-quinolinone. It is an activated molecule that can be used in organic synthesis as an amide or ester activator for the formation of amides and esters from carboxylic acids. Tert-butyl pyridine-3-carboxylate binds to the e3 ubiquitin ligase, which prevents its ability to interact with other proteins such as HIV protease. This drug also has a proton at the methyl nicotinate nitrogen atom, which may contribute to its activity against HIV.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>8-Bromo-4-chloroquinoline is a chemotherapeutic that inhibits the growth of cells in the human fibroblast cell line. It also has cytotoxic properties and can be used to treat breast cancer, colon cancer, and leukemia. Cytotoxicity is seen at concentrations of 8-bromo-4-chloroquinoline that are below the concentration required for DNA synthesis inhibition. The mechanism of action of 8-bromo-4-chloroquinoline is not well understood, but it may involve interaction with cytochrome P450 1A1 (CYP1A1) or other cellular proteins.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Octane-1-sulfonamide (OSA) is a glycol ether that is used as a reagent for biological samples. It reacts with the hydroxyl group on proteins, which causes the compounds to become more hydrophobic and interact with each other. The OSAs are also reactive with fatty acids, which leads to cross-linking of cell membranes. This interaction may be related to the low light activity of OSA. Octane-1-sulfonamide can also bind cationic polymers, which may be useful in ophthalmic drugs.</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 2,6-dichloropyridine-3-carboxylate is a carboxylic acid that can be synthesized by reacting 2,6-dichloropyridine with an acetyl chloride. It has been used in the synthesis of dopamine D2 receptor antagonists. The sulfoxide group in this compound may undergo alkaline hydrolysis to yield an anion and a nucleophilic adduct. This carboxylic acid also reacts with triethylamine to form esters. In addition, methyl 2,6-dichloropyridine-3-carboxylate is regioselective for the alpha position when it reacts with methyltetrahydrofuran.</p>

<p>6-Chloro-2-methoxynicotinic acid is a ketone that reacts with chlorine in the presence of light to form chlorinated products. It is a versatile intermediate for the synthesis of various compounds. 6-Chloro-2-methoxynicotinic acid is used in the synthesis of naphthacene, which is a precursor to dyes and pharmaceuticals. The reactivity of this compound depends on substituents located at the 2 position. Substituents cause sterically hindering effects and lead to different geometries and reactivities, such as attack by chlorine or substitution by hydrogen.</p>

<p>2-Methoxy-4,6-dimethylnicotinonitrile is a photoreactive compound that reacts with UV light to produce an adduct. The 1-cyanonaphthalene group in 2-methoxy-4,6-dimethylnicotinonitrile undergoes a photochemical reaction to form an adduct with the benzene ring. It is postulated that the dimer and x-ray structural analysis of 2-methoxy-4,6-dimethylnicotinonitrile are stable and pyridine can be used as a solvent.</p>

<p>2-Amino-4-(aminooxy)butanoic acid dihydrochloride is a cyclization product of the antibiotic cycloserine. It has been synthesised from 2-amino-4-oxobutanoic acid by the addition of hydrochloric acid and then heated to reflux for 20 hours. The purity of this product is &gt;98%.<br>2-Amino-4-(aminooxy)butanoic acid dihydrochloride has been shown to be a homologue of canaline, which is an antibiotic used in the treatment of tuberculosis. This compound also has antibacterial activity, although it is less potent than cycloserine.</p>

<p>(2E,4E)-Hepta-2,4-dienoic acid is an organic compound that belongs to the group of quinoline derivatives. It is a colorless liquid at room temperature and is soluble in organic solvents. This compound can be used as a dehydrohalogenating agent in the synthesis of mappicine and camptothecin derivatives. (2E,4E)-Hepta-2,4-dienoic acid can also react with ketocarboxylic acids to form carotenoid compounds. The chemical formula for this molecule is C8H10O3.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>