Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>9H-Fluoren-9-ylmethyl 4-hydroxypiperidine-1-carboxylate (Fmoc) is a primary alcohol that has been used extensively as a building block in the synthesis of cyclic peptides. Fmoc is often irradiated with microwaves to convert it into an activated form that can be coupled with other amino acids. The hydroxyl group on Fmoc can be used to synthesize hydroxylated molecules, such as 1,2,3,4-tetrahydroquinoline and 4-(chloromethyl)piperidine. This reagent has also been used for the synthesis of cyclic peptides by immobilization on resin beads. It is toxic at high doses and should be handled with care.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 4-(4-formyl-2-methoxyphenoxymethyl)benzoate is a custom synthesis. It has been shown to be an efficient methylating agent for the synthesis of oligosaccharides and polysaccharides. Methyl 4-(4-formyl-2-methoxyphenoxymethyl)benzoate has also been used for fluorination of complex carbohydrates, such as saccharides and monosaccharides. This chemical can also be used in the modification of carbohydrate chains by protecting hydroxyl groups with formaldehyde or acetal groups.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methyl-2-(phenylamino)propionitrile is a chemical compound that belongs to the class of cyanides. It can be extracted from various sources such as amines, mesoporous sulfamic acid and aldehydes. The reaction time for this product is efficient and yields are high, making it an ideal substance for use in organic synthesis. This compound has been shown to react with homopiperazine to form 2-methyl-2-(phenylamino)propionic acid, which is then converted into 1-phenylpiperazine by reacting with sulfamic acid. The yield obtained in this reaction was high at 98%. 2-Methyl-2-(phenylamino)propionitrile is also reusable and can be isolated after each reaction.</p>

<p>2-(Phenylamino)propanenitrile is a reactive c6 alkyl with an occlusive phosphate group that has been shown to be bactericidal in concentrations of 10 µg/ml. It is able to penetrate and damage the cell membrane of the bacteria, thereby inhibiting its ability to maintain homeostasis. 2-(Phenylamino)propanenitrile also has the ability to modulate muscle cell proliferation. This compound has been shown to reduce restenosis after angioplasty by reducing inflammation in damaged tissue and limiting the number of inflammatory cells that are recruited into the area.</p>

Vinyloxycyclohexane is an ether that is a reactive chemical species. It can be used as a crosslinking agent in the synthesis of biocompatible polymers. This polymer is often used as a substrate film for organic semiconductors, and has the ability to be modified with hydroxyl groups. Vinyloxycyclohexane has a basic structure, which may be due to its two hydroxyl groups and one vinyl group. This ether is also sensitive to heat, light, and radiation.

<p>2-(4-Chlorophenyl)propanenitrile is a model protein that is used to study the effects of sulfate and metal ion on the microbial transformation of acrylonitrile. This protein has been shown to be a substrate for thermophilic organisms and subunits are hydrated in water, with a ph optimum between 4.0-5.0. The molecule contains an amide bond that can be cleaved by carboxypeptidase, leading to the formation of benzonitrile. 2-(4-Chlorophenyl)propanenitrile can be immobilized on an insoluble support such as agarose or polyacrylamide gel using glutaraldehyde.</p>

<p>Versatile small molecule scaffold</p>

<p>2,3-Dimethyl-1,4-dihydronaphthalene-1,4-dione is a reactive compound that can be reduced to the corresponding 1,4-naphthoquinone. It has a redox potential of -0.11 V and is electron reducing. In vitro studies on rat liver microsomes have shown that 2,3-dimethyl-1,4-dihydronaphthalene-1,4-dione reduces NAD+ to NADH and oxidizes NADH back to NAD+. This compound has been shown to inhibit the growth of some bacteria and fungi in cell culture experiments. 2,3-Dimethyl-1,4-dihydronaphthalene-1,4-dione also has antiinflammatory properties that may be due to its ability to inhibit the production of prostaglandins by inhibiting cyclooxygenase activity.</p>

<p>Versatile small molecule scaffold</p>

<p>Ethyl 4,5-dimethyl-1H-pyrrole-2-carboxylate is a minimal inhibitory concentration antibiotic that inhibits the growth of bacteria by binding to their ribosomes. It inhibits protein synthesis and cell division, which leads to bacterial death. The methyl ester form has been isolated from a number of plants, including Javanica.</p>

<p>Ethyl 5-methyl-1H-pyrrole-3-carboxylate is a corticotropin-releasing factor (CRF) antagonist that has been shown to be an effective treatment for anxiety and depression. CRF antagonists are structurally related to the endogenous peptide, CRF, which regulates the hypothalamic-pituitary-adrenal axis. Ethyl 5-methyl-1H-pyrrole-3-carboxylate binds to the CRF receptor and blocks its activity, thus inhibiting the release of corticotropin from the pituitary gland. It is a bicyclic molecule that is closely related to other analogs such as alniditan, with similar properties. The discovery process of ethyl 5-methyl-1H-pyrrole-3 carboxylate was based on the synthesis of analogs with different structural features in order to find compounds that have a greater affinity for CRF receptors than</p>

Versatile small molecule scaffold

<p>Ethyl 4-formyl-3,5-dimethyl-1H-pyrrole-2-carboxylate (EFDMPC) is a reactive organic compound. EFDMPC contains an electron withdrawing group on the benzene ring and three electron donating groups on the pyrrole ring. This chemical has a molecular weight of 150.19 g/mol with a melting point of 159°C. The theoretical yield for this compound is 54%.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Spiro[2.5]octan-4-one is a three-membered ring that has absorptions in the range of 230 nm to 400 nm in the ultraviolet spectrum. It has an electronic spectrum with transitions at 12,770 cm and 13,620 cm. This compound has carbonyl groups and ketones as part of its structure. Spiro[2.5]octan-4-one absorbs at about 240 nm in the ultraviolet spectrum, which is due to its aliphatic nature.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(2-Methylphenoxymethyl)oxirane is a phenoxy compound that is used in the production of epoxies. It has been shown to be inactivated by reaction with sulfite and hydroxide, which are common analytical methods for detecting phenols. 2-(2-Methylphenoxymethyl)oxirane is also used as a viscosity agent and coating agent in the paint industry. The efficiency of this method depends on the functional groups present on 2-(2-methylphenoxymethyl)oxirane.</p>

<p>Versatile small molecule scaffold</p>

<p>1-Phenylimidazolidine-2,4,5-trione is a natural product with pharmacological properties. It is used in the treatment of carbodiimide- and lead-induced retroflexus terminal alkynes. 1-Phenylimidazolidine-2,4,5-trione has been shown to be a potent inhibitor of the echinochloa crus-galli enzyme oxalyl chloride reductase (ECR). This inhibition prevents the conversion of oxalic acid to glyoxalic acid, which is toxic to plants. 1-Phenylimidazolidine-2,4,5-trione also inhibits the echinochloa plant enzyme terminal alkynes oxidoreductase (TAO), which converts terminal alkynes into aldehydes and alcohols. The pyrimidine derivative has been shown to prevent growth of E. coli in lab tests.</p>

<p>Versatile small molecule scaffold</p>

<p>7-Fluorophthalide is a protoberberine alkaloid that is an intermediate in the biosynthesis of berberine. It has been shown to be a stereoselective (S) or stereochemical (R) and to have a high affinity for binding to the anion. 7-Fluorophthalide has also been shown to be a fluorinated analogue of protoberberines, which can be used as a starting point for developing new molecules with similar properties.</p>

<p>Versatile small molecule scaffold</p>

<p>N-Methylnaphthalen-2-amine is a metabolite of 2-naphthylamine that is excreted in the urine. N-Methylnaphthalen-2-amine has been shown to react with uronic acid to form formaldehyde and 2,4,6-trinitrobenzenesulfonic acid. This reaction can be used as a test for aromatic amines in urine. The metabolites of this substance are excreted in the urine and conjugated with glucuronic acid or sulfate.</p>

<p>2,4-Dinitrobenzene-1-thiol is a reactive, acidic chemical that has been shown to inhibit glyceraldehyde 3-phosphate dehydrogenase and carbonic anhydrase. 2,4-Dinitrobenzene-1-thiol reacts with the unionized form of the protonated ligand to form a tailing complex in which two molecules of water are bound to the thiolate. The second order rate constant for this reaction is</p>

<p>Versatile small molecule scaffold</p>

<p>4-Ethyl-2-methylphenol is a natural phenolic compound that can be found in the verbenaceae and rhipicephalus families of plants. It occurs as a colorless to yellow liquid with a pleasant odor. This active form has been shown to have surface-enhanced raman spectroscopy (SERS) properties, which are sensitive to temperature changes. 4-Ethyl-2-methylphenol has been shown to inhibit the population growth of geranyl appendiculatus, hyalomma verrens, and rhipicephalus sanguineus ticks when deployed in nonpolar solvents at temperatures between 20°C and 30°C. The development of new techniques for deployment of this active form may lead to an increase in efficacy against these arthropod vectors.</p>

<p>2-tert-Butyl-6-methylphenol is a chemical compound that is used as an intermediate in the synthesis of a number of other chemicals. It has been shown to be toxic to human liver cells and may contribute to environmental pollution. 2-tert-Butyl-6-methylphenol is a white, crystalline solid that melts at about 145 degrees Celsius. The solubility of this substance in water is low (about 1g/L) and it has a density of 0.964 g/mL at 20 degrees Celsius. This product can be prepared synthetically by reacting phenol with formaldehyde, hydrogen chloride, and methyl iodide. The structure of 2-tert-butyl-6-methylphenol contains two tertiary alkyl groups attached to the benzene ring with methyl groups on the second and third carbon atoms from the end of the chain. This product also reacts with lipoproteins in human blood samples and metal</p>

<p>3-Phenyl-imidazolidine-2,4-dione is an organic compound that is a white solid. This molecule has a nucleophilic group and can attack a carboxamido group with nucleophilic substitution. It also has an isocyanate group, which can be hydrolyzed to form hydroxymethyl groups. 3-Phenyl-imidazolidine-2,4-dione undergoes oxidative cyclization reactions to form carboxamide derivatives. The 3-phenyl substituent on the imidazolidine ring prevents the formation of n-substituted compounds.</p>

<p>3-Ethylimidazolidine-2,4-dione is a nucleophilic compound that reacts with carboxamides and isocyanates. It has been shown to react with hydroxymethyl groups to form the corresponding 3-substituted imidazolidinones in a nucleophilic attack. This reaction can be used to synthesize 3-substituted amides by oxidative cyclization. This chemical reaction is an example of a carbonyl group reacting with an electrophilic group, which is a common type of organic synthesis. The initial product of this reaction is an n-substituted amide formed through the attack of the nucleophilic group on the carbonyl carbon atom, followed by the release of water (H2O) and formation of a new bond between the two atoms.</p>

<p>3,8,8-Trimethyl-4-oxatricyclo[5.1.0.0,3,5]octane is an alkene that has a reaction rate of 3.6 × 10 M/s at 25 °C in acetonitrile with a pyridinium catalyst. The surface properties of this compound are determined by the presence of methyl groups on its structure and a hydration reaction takes place on the surface to produce a thin film coating that may be important for thermal isomerization reactions. 3,8,8-Trimethyl-4-oxatricyclo[5.1.0.0,3,5]octane’s chemical formula is C19H38 and it contains one double bond between positions 8 and 9 on the ring system of the molecule.</p>

<p>3-(4-Methoxyphenyl)propiolic acid is a triarylbismuth carboxylate that is produced by the reaction of 3-(4-methoxyphenyl)propionic acid with triaryl bismuth. The molecule has a diameter of ˜1.3 nm and exhibits strong diffraction peaks at 2θ=25.5°, 2θ=28.0°, and 2θ=30.2° in the IR spectrum. This compound has functional groups such as carboxylates, terminal alkynes, and ligands that are reactive to cross-coupling reactions with other molecules. Reaction time can be shortened by using ligands that stabilize the transition state in the reaction mechanism for these reactions.</p>

<p>3-Bromobenzenecarbothioamide is a molecule that is used in the study of the conformations of molecules. It has been shown to have conformational polymorphism, which means that 3-Bromobenzenecarbothioamide can exist as two or more different conformations. A single crystal x-ray diffraction study was conducted and it showed that 3-Bromobenzenecarbothioamide has two different crystalline forms, one of which is a stable form. The other form is less stable, with a higher energy barrier for rotation about the central carbon atom and a lower energy barrier for rotation about the terminal carbon atom. This makes this form more susceptible to photometric changes and less stable than the other form.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Vinyl-µ-caprolactam is a polymer that has a phase transition temperature at around -70°C. It has been used in the synthesis of nonsteroidal anti-inflammatory drugs, such as sulindac, and can be applied to polymerization reactions. N-Vinyl-µ-caprolactam is stable in the presence of strong acids and bases, but undergoes hydrolysis in the presence of water. This compound can be used as a fluorescence probe or to study biological properties. N-Vinyl-µ-caprolactam also forms stable complexes with many other compounds, including glycol ethers and polymers such as polycaprolactam and copolymers. The polymer is biocompatible and can be used as a model system for studying reaction mechanisms.</p>

<p>Pentamethylaniline belongs to a class of organic solvents and is used as a reaction medium for the polymerization of cationic monomers. It is also used as a reagent in clinical development, specifically for the synthesis of polyenes. Pentamethylaniline has been shown to have high melting point, which makes it useful in the production of gels. Pentamethylaniline has also been shown to be an effective solvent for copolymers and pyridine compounds. The copolymers are typically composed of pentamethylaniline and acrylonitrile, methyl methacrylate, or vinyl acetate. These copolymers can be crosslinked with dicumyl peroxide or benzoyl peroxide to produce polyene resins with varying properties. Pentamethylaniline is also used as a precursor in the synthesis of benzyl group-containing compounds, such as phenylethyl alcohol and benzyl chloride</p>