Building Blocks

Versatile small molecule scaffold

t-Butyl methyl fumarate is a white crystalline powder with a molecular weight of 236.2 g/mol and a solubility in water of 0.05 g/L at 20 °C. It is an organic solvent that can be used as an initiator for free radical polymerization reactions, such as vinyl polymers, which are homopolymers or copolymers derived from the monomer ethylene. t-Butyl methyl fumarate has a boiling point of -21 °C and can be used as a solvent for organic compounds. It is soluble in organic solvents such as xylene, benzene, toluene, and dichloromethane. In the gas phase it has been found to have a critical temperature of 143 °C with no observable melting point.

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Phenyl-1H-1,2,3,4-tetrazol-1-ol is a hydrophilic chemical that has been used as a coupling agent. It has been employed in the production of polyurethane elastomers and polyurethane foams. The substituents on this molecule can be classified as multilayer or sterically bulky. 5-Phenyl-1H-1,2,3,4-tetrazol-1-ol also regenerates easily by means of alkaline reactions and yields high yields under mild conditions. This compound is not soluble in water but is soluble in ethylene oxide and organic solvents. 5-Phenyl-1H-1,2,3,4-tetrazol-1-ol is hydrophobic and does not react with silver halides.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(Hydroxymethyl)benzaldehyde (2HB) is a reactive aldehyde that is used as a cancer drug. It binds to the receptor in the cell membrane and inhibits fatty acid synthesis, which prevents cell division. 2HB has been shown to inhibit tumor growth by inhibiting chemokines, proteins that act as chemoattractants for immune cells. 2HB also inhibits the growth of cultured leukemia cells through crosslinking of DNA. This reaction can be enhanced by UV light, resulting in covalent bonds between adjacent nucleotides. The reaction mechanism for this process is called metathesis reactions.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Clonidine hydrochloride is a drug used in the treatment of hypertension and other cardiac diseases. It belongs to the class of drugs called centrally acting alpha-2 adrenergic agonists. Clonidine hydrochloride is also used for its antihypertensive effects in patients with neurogenic orthostatic hypotension, diabetic neuropathy, and glomerular filtration rate. The long-term efficacy and safety profile of clonidine hydrochloride has been established in clinical trials that have shown it to be effective in reducing symptoms of chronic pain and opioid withdrawal, as well as improving quality of life. Clonidine hydrochloride may be administered orally or transdermally. Clonidine binds to both alpha-1 and alpha-2 adrenergic receptors, which are responsible for vasoconstriction, inhibition of renin secretion from the kidneys, decreased sympathetic nerve activity, and increased parasympathetic nerve activity. This drug also has a protective effect on bone cancer cells

Versatile small molecule scaffold

Versatile small molecule scaffold