Building Blocks

<p>Applications 2-Butynoic Acid is used as a reagent in the synthesis of BMS 911543 (B596075); a potent JAK2 inhibitor used as a potential treatment for myeloproliferative disorders. 2-Butynoic Acid is also used in the preparation of chirally pure 1,2,3,4-tetrahydroisoquinoline analogs as anti-cancer agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fitzgerald, M.A., et al.: J. Org. Chem., 80, 6001 (2015); Ramanivas, T., et al.: Eur. J. Med. Chem., 92, 608 (2015)<br></p>

<p>Applications 1-Bromodecane is used to react with Mg to prepare Grignard reagents which play an important role in formation of carbon-carbon bond. It is also used in preparation of biodegradable cationic gemini surfactants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rogers, R., et al.: J. Org. Chem., 39, 857 (1975); Talaba, P., et al.: J. Carbohyd. Chem., 16, 573 (1997); Jain, T., et al., J. Mater. Chem. C: Materials for Optical and Electronic Devices, 2, 994 (2014)<br></p>

<p>Applications 3,4,5-TRIHYDROXYBENZALDEHYDE HYDRATE (cas# 207742-88-9) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications Chloromethoxysulfonyl Chloride is a useful intermediate for organic synthesis. Chloromethoxysulfonyl Chloride is a useful reagent for the preparation of HIV-attachment inhibitor BMS-663068, and in the synthesis of water soluble benzimidazole derivatives useful for treatment of fasciolosis.<br>References Fox, R. J., et al.; Org. Process Res. Dev., 21, 1095 (2017); Flores-Ramos, M., et al.: Bioorg. Med. Chem. Lett., 24, 5814 (2014); Zheng, B., et al.: Org. Process Res. Dev., 16, 1827 (2012)<br></p>

<p>Applications 1,4-Cyclohexanedione, is a versatile building block in the synthesis of more complex compounds. This intermediate can be hydrolysed and decarboxylated to afford the desired dione.<br>References Nielsen. A.T., et al.: Org. Synth.,;Coll., 5, 288 (1973);<br></p>

<p>Applications 4-Chloro-2,6-dimethoxypyrimidine (cas# 6320-15-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Bromo-2-cyanopyridine (cas# 55758-02-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Air Sensitive<br>Applications A potent agonist at hOR17-4 (a human testicular olfactory receptor) and acts as a strong chemoattractant in sperm behavioral assays. The bourgeonal-hOR17-4 signaling pathway potentially governs chemical communication between sperm and egg and may be used to manipulate or block fertilization. Bourgeonal is an aromatic aldehyde used in perfumery. It has a fragrance reminiscent of lily of the valley, otherwise described as floral, watery, green and aldehydic. It is a pale yellow liquid at room temperature.<br>References Spehr, M., et al.: Science, 299, 2054 (2003)<br></p>

<p>Applications 2-chloro-1-(4-chlorophenyl)ethanone (cas# 937-20-2) is a useful research chemical.<br></p>

<p>Applications Bis(2-Oxo-3-Oxazolidinyl)Phosphinic Chloride (cas# 68641-49-6) is a useful research chemical.<br></p>

<p>Applications Methyl 3-(4-chlorophenyl)-3-oxopropanoate (cas# 22027-53-8) is a useful research chemical.<br></p>

<p>Applications 3-Dimethylamino-1-propyne is used as a reactant in the synthesis of quinazoline derivatives such as (2Z)-Afatinib (A355305) which may be used in the treatment of some cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tsou, H., et. al.: J. Med. Chem., 44, 2719 (2001)<br></p>

<p>Applications 5-Bromo-2-nitropyridine is employed as a reagent in the synthesis of novel benzinidazoles, potent inhibitors of TIE-2 and VEGFR-2 Tyrosine (T899975) kinase receptors.<br>References Hasegawa, M., et al.: J. Med. Chem., 50, 4453 (2007); Okaniwa, M., et al.: J. Med. Chem., 55, 3452 (2012)<br></p>

<p>Applications 8-Bromooctanoic Acid (cas# 17696-11-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Moisture, Light Sensitive<br>Applications Used for derivatization, TLC and HPLC separation, and fluorometric analysis of a wide range of naturally occurring acids, including bile and thromboxane B2.<br>References Clin. Chim. Acta., 214, 195 (1993), Anal. Lett., 26, 429 (1993)<br></p>

<p>Applications 2-Bromobenzoic acid is a sterically hindered ortho-bromo compound that is used as a starting material to synthesize quinazolinones (e.g. 8-Hydroxy-2-methyl-4(3H)-quinazolinone [H948330]).<br>References Liu, X., et al.: Angew. Chem. Int. Edit., 121, 354 (2009); Lu, G., et al.: Tetrahedron Lett., 46, 4255 (2005)<br></p>

<p>Applications Diphenyl Chlorophosphonate, is a building block used for the synthesis of various chemical compounds. It can be used for the synthesis of phosphate esters of polyhedral hydroxyboranes, showing enhanced tumor uptake.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bechtold, R., et al.: J. Med. Chem., 18, 371 (1975);<br></p>

<p>Applications Sodium 4-methylbenzenesulfinate (cas# 824-79-3) is a useful research chemical.<br></p>