Building Blocks

<p>Applications Forest fires are actually beneficial for ecosystems, provided they don’t happen too often. After a fire, plants germinate and grow incredibly fast. 2H-Furo[2,3-c]pyran-2-one, KAR2, is a compound in smoke responsible for promoting the seed germination of a wide range of plant species. The researchers named the compounds “the karrikins”, for “karrik”, an aboriginal word for smoke.<br>References Sakuma, H., et al.: .Agric Biol. Chem., 45, 443 (1981), Stevens, J., et al.: Plant Soil, 298, 113 (2007), Nelson, D., et al.: Plant Physiol., 149, 863 (2009),<br></p>

<p>Applications Furoyl Chloride is used in the preparation of novel dibenzothiepins that show antibiofilm activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stecoza, C. et al.: Curr. Org. Chem., 17, 113 (2013);<br></p>

<p>Applications 4-​Hydrazinobenzoic acid hydrochloride (cas# 24589-77-3) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 4-Nitrocatechol Sulfate Dipotassium Salt (cas# 14528-64-4) is a compound useful in organic synthesis.<br></p>

<p>Applications Hydroxyacetone is a chemical reagent used in various organic chemical reactions. It is a component of the Mannich reaction, amino acid caalyzes direct asymmetric aldol reactions. In the pharmaceutical setting, this compound is used in the synthesis of imidazoles acting as potent and orally active antihypertensive agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sakthivel, K. et al.: J. Am. Chem. Soc., 123, 5260 (2001); Carini, D. et al.: J. Med. CHem., 34, 2525 (1991); List, B. et al.: J. Am. Chem. Soc., 122, 9336 (2000);<br></p>

<p>Applications 2-Hydroxybenzyl Alcohol is a phenolic component of a part of a salix bark extract which maintains a minor anti-depressant effect. Phenolic analog with potential for anti-melanomic effect<br>References Ulrich-M. et al.: Phytomed., 19, 930 (2012); Vad, N. et al.: Chem-Biol. Int., 183, 462 (2010);<br></p>

<p>Applications 2'-Hydroxybiphenyl-3-carboxylic acid<br></p>

<p>Applications 2-Hydroxyisobutyric Acid is used as a reagent in the preparation of fully functionalized tetronic acids. Also used in the synthesis of bioisosteres of trimethadione, N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides from α-hydroxyamides which display anticonvulsant activity.<br>References Prousis, K., et al.: Tetrahedron, 71, 8637 (2015); Pastore, V., et al.: Bioorgan. Med. Chem., 21, 841 (2013);<br></p>

<p>Applications Imidazo[1,2-a]pyridine is one of four imidazopyridine isomers. Imidazopyridine derivatives possess activity as inhibitors of target enzymes and have medicinal and pharmaceutical applications and are used as herbicides and fungicides.<br>References Liu, J. et al.: Huax. Jinz., 22, 631 (2010);<br></p>

<p>Applications 2,2’-Iminobis(N-(2,6-Dimethylphenyl)acetiamide is an impurity in the synthesis of Lidocaine Hydrochloride (L397800), an anesthetic local agent and antiarrythmic class IB agent.<br>References Duce, R., et al.: J. Pharmacol. Exp. Ther., 179, 580 (1971), Kronberg, G.H., et al.: J. Med. Chem., 16, 739 (1973), Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985), Davies, P.S., et al.: Drugs, 64, 937 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications Nitrosophenidylate is an N-nitroso derivative of Methylphenidate Hydrochloride(M325880), which is a controlled substance (stimulant). CNS stimulant. Four isomers of Methylphenidate are known to exist. One pair of threo isomers and one pair of erythro are distinguished, from which only d-threo-Methylphenidate exhibits the pharmacologically usually desired effects. This compound is a 4:1 mixture of rac-erythro (M325670) and rac-threo (M325671).<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., Anal. Profiles Drug Subs., 10, 473 (1981), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),<br></p>

<p>Applications A substrate for the determination of lactate dehydrogenase isoenzymes.This compound is suitable for lactate dehydrogenase (LDH) related research.<br>References Hegeman, G., et al.: J. Bacteriol., 91, 1155 (1966), Dobritzsch, D., et al.: J. Biol. Chem., 273, 20196 (1998), Chang, A., et al.: Biochem. J., 339, 255 (1999),<br></p>

<p>Applications Malonic Acid, is a small bioactive molecule, that can be used in variuos reactions. It is the classic example of a competitive inhibitor, which acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain.<br>References Weiner, N., "Malonic acid", Org. Synth.; Coll. Vol. 2: 376;<br></p>

<p>Impurity Atenolol Impurity 3; Atenolol Impurity 1<br>Applications Atenolol Impurity 3. Atenolol Impurity 1.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-(4-methylphenyl)oxirane (cas# 13107-39-6) is a useful research chemical.<br></p>

<p>Applications Has binding affinity to guanine deaminase, an important metalloenzyme in purine catabolism. Found in urine of patients with malignant cancer.<br>References Fernandez, J. et al.; Bioorg. Med. Chem.; 18, 6748 (2010); Li, H. et al.; J. Mass. Spectrom. 44, 641 (2009)<br></p>

<p>Stability Moisture Sensitive<br>Applications Malonic Acid-d4 is the isotope labelled analog of Malonic Acid (M158005); a small bioactive molecule that can be used in various reactions. It is the classic example of a competitive inhibitor which acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain.<br>References Weiner, N., "Malonic Acid", Org. Synth.; Coll. Vol. 2: 376<br></p>