Building Blocks

<p>Applications Alizarin is used widely as a prominent red dye for textile facbrics. Alizarin red is now used in biochemical assay to determine quantitatively by colorimetry, the presence of calcific deposition by cells of the osteogenic lineage. Alzarine derivatives was evaluated as new inhibitors of the HIV-1 reverse transcriptase associated DNA polymerase and RNase H. Alizarin was also shown to inhibit proliferation, tumor growth and suppress tumorigenesis in human osteosarcoma and breast cancer cell representative for bone metastasis. Dyes and metabolites.<br>References Yuan, H.S., et al.: Mycol., 3, 100 (2012); Esposito, F. et al.: FEBS. J., 278, 1444 (2011); Fotia, Caterina, J. Orthop. Rsch. 30, 1486 (2012);<br></p>

<p>Applications Methyl 5-Aminopentanoate Hydrochloride is used as a reactant to synthesize several compounds with therapeutic potential.<br>References Larson, Peter, et al.: ACS Med. Chem. Let, 8(11), 1148-1152 (2017);Li, Yongtao, et al.: J. of Med. Chem., 61(7), 3166-3192 (2018);Lu, Yuzhi, et al.: ACS Med. Chem. Let., 7(12), 1185-1190 (2016)<br></p>

<p>Applications Benznidazole (BNZ) is traditionally used to treat Chagas disease caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, Nifurtimox and Benznidazole, are toxic and present severe side effects.<br>References Abuin, G., et al.: Mol. Biochem. Parasitol ., 35, 229 (1989), Arora, P., et al.: J. Biol. Chem., 270, 6042 (1995), Campos, M., et al.: J. Immunol., 167, 416 (2001), Faundez, M., et al.: Antimicrob. Agents Chemother., 49, 126 (2005),<br></p>

<p>Applications 3,4,5-Trimethoxyphenylacetic Acid is a reagent in the preparation of 3-phenylcoumarins as antidepressant agents.<br>References Sashidhara, K.V., et al.: Bioorg. Med. Chem. Lett., 24, 4876 (2014);<br></p>

<p>Applications Calcium α-Hydroxy-γ-Methylmercaptobutyrate is useful in ion pairing inside Mammals and is therefore useful when it comes to nitrogen retention allowing for animal to grow quickly.<br>References Opapeju, F., et al.: Animal., 6, 1750-1756 (2012)<br></p>

<p>Stability Air Sensitive, Light Sensitive, Moisture Sensitive, Temperature Sensitive<br>Applications N-Acetyl-4-benzoquinone Imine (NAPQI) is a toxic metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3). N-Acetyl-4-benzoquinone Imine can react with cysteine residues of hepatic proteins to yield Acetaminophen-cysteine (A161255) (4).<br>References (1) Jaeschke, H., et al.: Toxicol. Sci., 89, 31 (2006) (2) O’Malley G. F., et al.: J Med Toxicol. 11, 317 (2015)(3) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(4) Frey, S. M., et al.: J Med Toxicol. 11, 218 (2015)<br></p>

<p>Applications (S)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Hydrochloride is used as a reagent in the synthesis of valuable β-amylalkyl-β-amino acid enantiomers.<br>References Tasnadi, G., et al.: Org. Biomol. Chem., 8, 793 (2010)<br></p>

<p>Applications 4-Methylenepiperidine Hydrochloride is a building block that can be coupled with aryl halides via Suzuki cross-coupling to give benzyl piperidines and related compounds.<br>References Vice, S., et al.: J. Org. Chem., 66, 2487 (2001);<br></p>

<p>Applications 1-(Bromoacetyl)pyrene is a novel photoinitiator.<br></p>

<p>Applications 2-Phenylacetimidamide hydrochloride (cas# 2498-46-6) is a useful research chemical.<br></p>

<p>Applications trans,trans-2,4-Decadienal is an aldehyde with a fat flavor aroma characteristic of chicken but has a citrus odor at lower concentrations. trans,trans-2,4-Decadienal can be found in butter, cooked beef, fish, potato chips, roasted peanut, buckwheat and wheat bread crumb.<br>References Janes, D. et al.: Food Chem., 112, 120 (2008); Vermeulena, N. et al.: J. Cer. Sci., 45, 78 (2007);<br></p>

<p>Applications 8-Bromo-1-octene, is a building block used for the synthesis of more complex pharmaceutical compounds, such as Dithienogermole (DTG) derivatives with varying alkyl chain lengths and pendant functionalities.<br>References Zong, K., et al.: Org. Lett., 15, 1032 (2013);<br></p>

<p>Applications p-Toluoyl chloride is an aromatic compound used as a reagent to synthesize (+)-Yashabushitriol, a plant metabolite that is naturally found in the male flowers of Alnus sieboldiana matsum. p-Toluoyl chloride is also used as a reagent to prepare derivatives of Desloratadine (D290250). Desloratadine is a selective H1-receptor antagonist that has anti-inflammatory effects and is used to treat patients with allergic rhinitis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Berger, W.. et al.: Ann. All. Asth. Immun., 89, 485 (2002); Fang, Z., et al.: Tetrahedron Lett., 54, 6834 (2013); Feldman, K. &amp; Simpson, R.: Tetrahedron Lett., 30, 6985 (1989); Mu, S., et al.: Chin. Chem. Lett., 24, 531 (2013)<br></p>

<p>Applications δ-Decalactone is a naturally occurring cyclic ester used by food and flavor industries for its coconut fragrance and taste. It is also used as a reagent in the synthesis of (±)-Massoilactone (M197600); a chemical component with antibacterial activity found in volatile oils.<br>References Schneiderman, D.K., et al.: J. Chem. Educ., 91, 131 (2014); Rali, T., et al.: Molecules, 12, 149 (2007); Zhao, J., et al.: Nat. Prod. Commun., 4, 1491 (2009); Jin, Z., et al.: Med. Plant, 3, 45 (2012)<br></p>

<p>Stability Moisture Sensitive<br>Applications A non-cyclic silicone oligomer. Used in the methylation of mercury(II) salts. Study shows that it transformed by a specific microflora and in the natural environment degraded by mechanisms similar to other organic compounds.<br>References Radeva, E. et al.: J. Optoelec. Adv. Mat., 11, 1432 (2009); Wasserbauer, R. et al.: Folia Microbiologica, 35, 384 (1990); Watanabe, N. et al.: Ecotoxic. Env. Safety, 11, 174 (1986);<br></p>

<p>Applications A optically active metabolite of Tramadol.<br>References Lintz, V.W., et al.: Arzneim.-Forsch./Drug Res., 31, II, 11, 1932 (1981)<br></p>

<p>Impurity Ranitidine EP Impurity F<br>Stability Hygroscopic<br>Applications 5-(Dimethylaminomethyl)-2-furfuryl Alcohol Hydrochloride (Ranitidine EP Impurity F) is an intermediate in the synthesis of Ranitidine hydrochloride (R120000).<br>References Salameh, A., et al.: J. Food Sci., 71, 10 (2006), Guerrieri, P., et al.: Pharm. Res., 24, 147 (2007),<br></p>

<p>Applications 4,4’-Bis(maleoylamino)azobenzene is a novel azobenzene derivative and a bifunctional crosslinker used for directed modification of proteins and other crosslinking processes.<br>References Hien, L.T., et al.: Russ. J. Bioorg. Chem., 35, 549 (2009); Kamenjicki, M., et al.: Macromolecules., 37, 8293 (2004);<br></p>