Building Blocks

<p>Applications 2-METHYL-3-PHENYLPROPIONALDEHYDE (cas# 5445-77-2) is a useful research chemical.<br></p>

<p>Applications 10H-Phenothiazine 5-Oxide is a by-product in the synthesis of Phenothiazine S,S-Dioxide (P297600). Phenothiazine S,S-Dioxide is a derivative of Phenothiazine (P318040), a key component of antipsychotic and antihistaminic drugs.<br>References Bansode, T., et al.: Eur. J. Med. Chem., 44, 5094 (2009); Baell, J., et al.: J. Med. Chem., 53, 2719 (2010); Howard, P., et al.: Environ. Sci. Technol., 44, 2277 (2010); Koren, J., et al.: J. Biol. Chem., 285, 2498 (2010); Amobi, N., et al.: Eur. J. Pharmacol., 627, 285 (2010)<br></p>

<p>Applications Glyoxylic Acid is used as a reagent in the synthesis of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-L-leucine, a novel nonpeptide chemotype selective for neurotensin receptor 2. Also used as a reagent in the synthesis of elemonic acid derivatives as Pin1 inhibitors.<br>References Thomas, J.B., et al.: Bioorg. Med. Chem. Lett., 25, 292 (2015); Li, X., et al.: Bioorg. Med. Chem. Lett., 24, 5612 (2014)<br></p>

<p>Applications An intermediate in the manufacturing of pressor amines. The sulfate salt is used as topical vasoconstrictor.<br>References Zhang, L., et al.: Biochem. J., 340, 255 (1999), Miyazaki, M., et al.: J. Biol. Chem., 278, 33904 (2003), Li, C., et al.: Bioorg. Med. Chem. Lett., 19, 5214 (2009),<br></p>

<p>Applications D-Glutamic Acid is the unnatural (R)-enantiomer of Glutamic Acid, a non-essential amino acid. Its salt form (glutamate) is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. Glutamic Acid is also a key molecule in cellular metabolism.<br>References McEntee, W. et al.: Psychopharmacology, 111, 391 (1993); Manev, H. et al.: Mol. Pharmacol., 36, 106 (1989);<br></p>

<p>Applications A product from thermal and hydrolytic degradation of Orlistat. Orlistat impurity.<br>References Stalder, H., et al.: Helv. Chimica Acta, 75, 1593 (1992),<br></p>

<p>Applications 4,4-diethylcyclohexan-1-amine hydrochloride (cas# 1087747-58-7) is a useful research chemical.<br></p>

<p>Stability Air Sensitive, Moisture Sensitive<br>Applications (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate hydrate (cas# 41468-25-1) is a useful research chemical.<br></p>

<p>Applications 17a-Oxa-D-homo-5β-androst-1-ene-3,17-dione is a metabolite in the urine of men following treatment with Δ1-testololactone, which is an idiopathic oligospermic infertility. Also, it is derived from Androstenedione (A637550), which is a testosterone precursor and metabolite with androgenic activity. Controlled substance (anabolic steroid).<br>References Yaeger, R. L., et al.: Drug Metab. Dispos., 13, 107-109 (1985); Walker, V.R., et al.: Anal. Biopchem., 234, 194 (1996), King, D.S., et al.: J. Am. Med. Assoc., 281, 2020 (1999)<br></p>

<p>Applications Dimethyl Itaconate is a chemical reagent used in the synthesis of functionalized 2-isoxazolines used in fragment-based drug discovery.<br>References Tran, N. et al.: Tetrahedron Lett., 56, 4119 (2015); Louise Hazeland, E. et al.: Chem. Comm., 51, 10206 (2015);<br></p>

<p>Applications 3,4-Dimethoxyaniline is used as a reagent in the synthesis of 2-aminothiazoles as sphingosine kinase inhibitors. It is also used in the synthesis of pyridine-3-carboxamide-6-yl-ureas which exhibit antimicrobial activity.<br>References Yule, I.A., et al.: Eur. J. Med. Chem., 86, 31 (2014); Vogt, D., et al.: Bioorg. Med. Chem., 22, 5354 (2014)<br></p>

<p>Applications 6,7-Dimethoxyisoquinoline is used as an organocatalyst in the chemoselective O-tert-butoxycarbonylation of phenols.<br>References Saito, Yukako, et al.: Tetrahedron Let., 51(52), 6915-6917 (2010)<br></p>

<p>Applications Cinnamic Acid derivative<br>References Sato, M., et al.: Chem. Pharm. Bull., 42, 521 (1994), Remiszewski, S., et al.: J. Med. Chem., 46, 4609 (2003),<br></p>

<p>Applications 4-Formylbenzoic Acid Methyl Ester is a benzoic acid derivative with antioxidant activity.<br>References Conde, E. et al.: Food Chem., 114, 806 (2009);<br></p>

<p>Stability Air sensitive, Light Sensitive<br>Applications trans-Methyl-2-butenal is a reagent used in the synthesis of a cell adhesion inhibitors Peribysin E analog. Also used in the preparation of thiolactomycin-based KasA inhibitors in the treatment of tuberculosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Handore, Ki. et al.: Org. Lett., 15, 1894 (2013); Kapilashrami, K. et al.: J. Biol. Chem., 288, 6045 (2013);<br></p>

<p>Applications 2,4'-Dihydroxydiphenylmethane can be used in anisotropically conductive paste containing thermosetting compd. and solder particles with improved reliability.<br>References Ishizawa, H., et al.: Jpn. Kokai Tokkyo Koho, JP 2016066614 A 20160428 (2016);<br></p>

<p>Applications A metabolite of aldehydes.<br>References Shiobara, Y., et al.: Xenobiotica, 9, 157 (1979),<br></p>