Building Blocks

<p>Stability Corrosive<br>Applications Ethyl 2-Bromopropionate is an intermediate in the synthesis of organic compounds and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhang, Li., et al.: Bioorg. Med. Chem., 18, 7948 (2010); Roberts, D.W., et al.: Chem Res. Toxicol., 23, 228 (2010);<br></p>

<p>Applications A sulfonate ester as potential genotoxic impurity in drug substances. It may exert genotoxic effects in bacterial and mammalian cell systems.<br>References Eder, E., et al.: Xenobiotica, 12, 831 (1982), Li, W., et al.: J. Chromatogr., 1046, 297 (2004), Glowienke, S., et al.: Mutat. Res., 581, 23 (2005), Colon, I., et al.: J. Pharm. Biomed. Anal., 39, 477 (2005),<br></p>

<p>Stability Light Sensitive<br>Applications 2-Bromopropionic Acid Benzyl Ester (cas# 3017-53-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(oxan-4-yl)-1H-1,2,3-triazole-4-carboxylic acid (cas# 1487610-80-9) is a useful research chemical.<br></p>

<p>Stability Temperature sensitive - closes readily. Store at -80°C<br>Applications Used for isolating bases by means of Reinecke's salt.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dudley, H., et al.: Biochem. J., 27, 157 (1933),<br></p>

<p>Applications 6-Bromo-1-hexanol is a useful synthetic intermediate. 6-Bromo-1-hexanol is used as a reagent in the preparation of nitric oxide-donating analogues of Sulindac (S699215), a non-steroidal anti-inflammatory drug that has the ability to prevent colon cancer.<br>References Nortcliffe, A., et al.: Bioorg. Med. Chem., 22, 756 (2014); Pasricha, P., et al.: Gastroenterology, 109, 994 (1995); Yamamoto, Y., et al.: J. Biol. Chem., 274, 27307 (1999)<br></p>

<p>Applications 1-Bromonapthalene is used in the preparation of N-aryl imidazoles and diaryl ethers. Also used in the preparations of glutathione peroxidase-like antioxidant activity of diaryl diselenides.<br>References Ghorbani-Vaghei, R. et al.: Tetrahedron Lett., 54, 7095 (2013); Mugesh, G. et al.: J. Am. Chem. Soc., 123, 839 (2001);<br></p>

<p>Applications 2,5,6,7-tetrahydro-1H-azepin-2-one (cas# 2228-79-7) is a useful research chemical.<br></p>

<p>Applications o-Iodohippuric Acid is used as a probe to measure renal function and clearance.<br>References Galinsky, R. et al.: Mech. Age. Dev., 56, 209 (1990);<br></p>

<p>Stability Hygroscopic<br>Applications 3-​Hydroxy-​2-​(methyl-​d3)​-​5-​[(phosphonooxy)​methyl]​-4-​pyridinecarboxaldehy​de is the labelled version of pyridoxal 5'-phosphate(P991715); a vitamin (enzyme co-factor).<br>References Lichstein, et al.: J. Biol. Chem., 161, 311 (1945), McPhalen, C., et al.: J. Mol. Biol., 225, 495 (1992), Fenn, T., et al.: Biochemistry, 44, 5317 (2005),<br></p>

<p>Applications 5-Iodouracil is a halogenated pyrimidine that can be used in nucleoprotein photo-crosslinking via RNA substitution. 5-Iodouracil is used in thymidine phosphorylase targeted imaging and therapy. Studies show that DNA N-glycosylase MED1 exhibited higher preference for 5-Iodouracil and halogenated bases over non-halogenated ones.<br>References Meisenheimer, K. et al.: Meth. Enzymol., 318, 88 (2000); Klecker, R.W. Jr. et al.: Cancer Chemother. Pharmacol., 48, 407 (2001); Turner, D.P. et al.: Cancer Res., 66, 7686 (2006);<br></p>