Building Blocks

<p>Applications 2,5-Dimethylpyrazine is used as a reagent in the synthesis of bone-targeted proteasome inhibitors for multiple myeloma (MM). 2,5-Dimethylpyrazine is also used in the preparation of 3-Methyl-2,5-bis-(2-hydroxyethyl)pyrazine (M295340); a degredation product of Clavulanic Acid (C563750) which is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.<br>References Agyin, J.K., et al.: Bioorg. Med. Chem. Lett., 23, 6455 (2013); Reading, C. and Cole, M.: Antimicrob. Ag. Chemother., 11, 852 (1977); Ball, A.P., et al.: Lancet, 1, 620 (1980); Brogden, R.N., et al. Drugs, 22, 337 (1981); Haginaka, J. et al.: Chem. Pharm. Bull., 33, 218 (1985)<br></p>

<p>Applications 2,2':6',2''-Terpyridine (cas# 1148-79-4) is a useful research chemical.<br></p>

<p>Applications 3,5-Dimethylpyrazole his a catalyst in the sulfonation of acetic anhydride to sulfoacetic acid and methanedisulfonic acid. 3,5-Dimethylpyrazole has been used in the synthesis of bipyrazolic tripodal derivatives with in vitro antitumor, antifungal and antibacterial activities.<br>References Jianrattanasawat, S., Mezei, G.: Inorg. Chim. Acta, 384, 318 (2012); Radi, S., et. al.: Lett. Drug Design Disc., 9, 305 (2012); Radi, S., et. al.: Res. J. Chem. Sci., 2, 40 (2012)<br></p>

<p>Applications 3,4-Dimethylpyrazole (cas# 2820-37-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 4,4-diethylcyclohexan-1-amine hydrochloride (cas# 1087747-58-7) is a useful research chemical.<br></p>

<p>Applications Dimethyl Itaconate is a chemical reagent used in the synthesis of functionalized 2-isoxazolines used in fragment-based drug discovery.<br>References Tran, N. et al.: Tetrahedron Lett., 56, 4119 (2015); Louise Hazeland, E. et al.: Chem. Comm., 51, 10206 (2015);<br></p>

<p>Applications Trans, trans, trans-1,5,9-cyclododecatrene - (CAS# 676-22-2) is a useful research chemical compound.<br></p>

<p>Stability Hygroscopic<br>Applications Dimethylaminoethanol is used as a curing agent for polyurethanes and epoxy resins. It is also used in mass quantities for water treatment, and to some extent in the coatings industry. It is used in the synthesis of dyestuffs, textile auxiliaries, pharmaceuticals, emulsifiers, and corrosion inhibitors. It is also an additive to paint removers, boiler water and amino resins.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Littel, R., et al.: J. Chem. Eng. Data, 35, 276 (1990); Sanders, M., et al.: J. Phys. Chem. A, 113, 10143 (2009); Zahniser, N., et al.: J. Pharmacol. Exp. Ther., 200, 545 (1977);<br></p>

<p>Applications N,N-Dimethyl-o-toluidine is a building block that has been used as an epoxy catalyst for curing Epon 828. (CAS 25068-38-6).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Robins, J., Young, C.: Polym. Preprints, 27, 165 (1986)<br></p>

<p>Impurity Ranitidine EP Impurity F<br>Stability Hygroscopic<br>Applications 5-(Dimethylaminomethyl)-2-furfuryl Alcohol Hydrochloride (Ranitidine EP Impurity F) is an intermediate in the synthesis of Ranitidine hydrochloride (R120000).<br>References Salameh, A., et al.: J. Food Sci., 71, 10 (2006), Guerrieri, P., et al.: Pharm. Res., 24, 147 (2007),<br></p>

<p>Stability Light Sensitive<br>Applications 2-Bromopropionic Acid Benzyl Ester (cas# 3017-53-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Amino-4-(trifluoromethyl)benzenethiol Hydrochloride can be used as reactant/reagent in preparation of fused benzo-diazepinones/oxazocinone/thiazapines/diazapines/diazocins/thiazine/indoles via CuI-L-proline catalyzed SN2 reaction.<br>References Srinivasulu, V., et al.: Tetrahedron, 73, 2139 (2017)<br></p>

<p>Applications 2-​Amino-​3-​chloro-​5-​trifluoromethylpyrid​ine acts as a reactant in the synthesis of novel imidazo[1,2-a]pyridine-coumarin hybrid molecules as inhibitors of NS5B in potential treatment of Hepititis C.<br>References vManvar, P. et al.: Tetrahedron 72, 1293 (2016);<br></p>

<p>Stability Very Very Moisture Sensitive<br>Applications Dichlorotriphenylphosphorane is a reagent used in the synthetic preparation of sulfonamides. Also used to prepare O-alkylated benzamides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, Y. et al.: RSC. Adv., 5, 4171 (2015); Prabhakaran, P. et al.: Tetrahedron, 68, 4485 (2012);<br></p>

<p>Applications 1-Aminopyrene is used in the synthesis of novel fluorescent nanoscale ionic silicate platelets for use in bacterial detection and other biosensor applications.<br>References Lin, H.. et al.: ACS App. Mater. Inter., 7, 10771 (2015);<br></p>

<p>Applications 2-(2-Aminoethylamino)ethanol is a reagent used in the synthesis of various pharmacologically active compounds and functional groups. Its used in the synthesis of antitumor anthracene-diones and antitumor DNA intercalators. More recently used in the synthesis of ionic liquids with various thermal, dielectric and catalytic properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bair, K. et al.: J. Med. Chem., 33, 2385 (1990); Krapcho, A. et al.: J. Med. Chem., 37, 828 (1994); Karadag, A. et al.: J. Mol. Liq., 177, 369 (2013);<br></p>