Building Blocks

<p>Applications H-PRO-GLU-OH (cas# 67644-00-2) is a useful research chemical.<br></p>

<p>Applications: Intermediate in the preparation of Propantheline Bromide.<br></p>

<p>Applications (S)-Pulegone is the stereoisomer of (R)-Pulegone (P840140) which is a monoterpene, commonly found in the essential oils of Nepeta cataria (Catnip).<br>References Sonboli, A., et al.: Chem. Biodivers., 7, 1784 (2010), Ntalli, N., et al.: J. Agric. Food Chem., 58, 7856 (2010), Chun, M., et al.: Microchem. J., 95, 25 (2010)<br></p>

<p>Applications Purine (cas# 120-73-0) is a useful research chemical.<br></p>

<p>Applications Pyridine Hydrochloride is the hydrochloride salt of pyridine, a basic six-membered heterocyclic ring. Pyridine is a base structure present in many biologically active compounds like the vitamins niacin and pyridoxal. Pyridine is used in dehalogenation reactions and can be used as a base in condensation reactions.<br>References Egyed, J. et al.: Bull. Soc. Chim. Fra., 11, 3014 (1973); Li, Y. et al.: Wuli HUa. Xueb., 14, 1048 (1998);<br></p>

<p>Applications L-Selenomethionine promotes cell cycle progression and is known to elevate the expression of the antioxidant enzymes thioredoxin reductase, glutathione reductase, and glutathione peroxidase. It has also been shown to selectively induce apoptosis in LNCaP prostate cancer cells without affecting non-cancerous cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zeng, H., et al.: J. Nutr., 132, 674 (2002); Sayed, W., et al.: Toxicol. In Vitro, 21, 157 (2007); Jornot, L., et al.: Biochem. J., 306, 581 (1995); Stewart, J., et al.: Nutr. Cancer, 60, 826 (2008)<br></p>

<p>Applications 3-BROMOPHENANTHRENE (cas# 715-50-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Pyridinium p-Toluenesulfate is used in the synthesis of a subdomain of the cytochrome P450 BM3 enzyme, for use in screening systems for drug candidates.<br>References Erkelenz, M. et al.: J. Am. Chem. Soc., 133, 16111 (2011);<br></p>

<p>Applications Tiglic acid is the stable isomer of angelic acid. Tiglic acid was found as glyceride in croton oil, as butyl ester in the oil of the Roman camomile, and as geranyl tiglate in oil of geranium. Tiglic acid is formed during the charcoaling of maple wood.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bueding, et al.: J. Biol. Chem., 202, 505 (1953),<br></p>

<p>Applications Competitive inhibitor of butyrobetaine hydroxylase<br>References Decristoforo, C., et al.: Nuc. Med. Biol., 26, 389 (1999), Rose, N., et al.: J. Med. Chem., 51, 7053 (2008),<br></p>

<p>Stability Hygroscopic<br>Applications Used in nucleophilic substitution.<br>References Genicot, C., et al.: Bioorg. Med. Chem. Lett., 13, 437 (2003),<br></p>

<p>Applications 2-Bromoacetonitrile is a water disinfectant byproduct. 2-Bromoacetonitrile has been found to show mutagenic activity on Salmonella typhimurium strain TA100.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahmed, A.E., et. al.: Toxicol. Appl. Pharm., 100, 271 (1989); Le Curieux, F., et. al.: Mutat. Res-genet. Tox., 341, 289 (1995)<br></p>

<p>Applications 4-Bromobenzoic Acid Methyl Ester is halogenated benzoate used as a reagent in organic synthesis. 4-Bromobenzoic Acid Methyl Ester can be used to stimulate microbial dechlorination of PCBs. 4-Bromobenzoic Acid Methyl Ester is also used in the preparation of stable radioiodinating reagent to label monoclonal antibodies for radiotherapy of cancer.<br>References Wilbur, D.S. et al.: J. Nuclear Med., 30, 216 (1989); DeWeerd, K.A. et al.: Environ. Sci. Technol., 33, 2057 (1999);<br></p>

<p>Applications 1,1,3,3-Tetraethoxypropane has been used in the preparation of diazabicyclodecenes.<br>References Barykina-Tassa, O.V., Snider, B.B.: Tetrahedron Lett., (Ahead of Print) (2015)<br></p>

<p>Applications 2,5-Xylidine, is a Vanillin derivative, used as as potential inhibitors of FtsZ. These compounds were also assayed for antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, etc.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sun, J., et al.: Med. Chem. Res. (2013);<br></p>

<p>Applications Bromocyclohexane is s used in the synthetic preparation and regioselective bromination of sp3 C-H bonds by organophotoredox catalysis.<br>References Kee, C.W., et al.: Asian. J. Org. Chem., 3, 536 (2014)<br></p>

<p>Applications (+)-(S)-Tylophorine is a a major alkaloid of Tylophora indica. (+)-(S)-Tylophorine is an immunosuppressant and inflammation inhibitor. (+)-(S)-Tylophorine showed antiproliferative activity and induction of apoptosis in tumor cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gopalakrishnan, C. et a.: Ind. J. Med. Chem., 71, 940 (1980); Ganguly, T.et al.: Phytomedicine, 9, 288 (2002); Gao, W. et al.: Cancer, Res., 64, 678 (2004);<br></p>

<p>Stability Hygroscopic<br>Applications Trimethyl Orthobenzoate is a reagent used in the synthesis of quinazolines. Also used in the prepaaration of nintedanib (N478290), used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.<br>References Bhat, S. et al.: J. Hetero. Chem., 52, 1253 (2015); Xu, R. et al.: J. Labelled. Comp. Radiopharm., 58, 308 (2015);<br></p>