Building Blocks

<p>Applications 2-(Bromomethyl)benzonitrile is an intermediate in the synthesis of Alogliptin (A575425), an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Antidiabetic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lai, Z., et. al.: Eur. J. Med. Chem., 83, 547 (2014); Lynn, F., et al.: Diabetes, 50, 1004 (2001); Trumper, A., et al.: J. Endocrinol., 174, 233 (2002); Vollmer, K., et al.: J. Clin. Endocrinol. Metab., 94, 1379 (2009)<br></p>

<p>Applications An intermediate in the metabolism of tyrosine and phenylalanine. Occurs in plants and in the urine of alkaptonurics.<br>References Knox, W.E., et al.: Biochem. J., 49, 686 (1951), LaDu, B.N., et al.: J. Biol. Chem., 217, 777 (1955)<br></p>

<p>Applications Trimebutine (T795605) impurity standard.<br>References Wang, J., et al.: Br. J. Pharmacol., 113, 945 (1994), Chen, D., et al.: Bioorg. Med. Chem., 5, 1715 (1997), Min, H., et al.: Bioorg. Med. Chem. Lett., 18, 523 (2008),<br></p>

<p>Applications 3-(4-Hydroxyphenyl)propionic Acid Methyl Ester is a useful synthetic intermediate. It can be used to prepare potent and orally available G protein-coupled receptor 40 agonists as potential antidiabetic agents.<br>References Sasaki, S., et al.: J. Med. Chem., 54, 1365 (2011); Christiansen, E., et al.: ACS Med. Chem. Lett., 1, 345 (2010)<br></p>

<p>Applications cis-1,3-O-Benzylideneglycerol (cas# 4141-19-9) is a compound useful in organic synthesis.<br></p>

<p>Applications A reagent used for the synthesis of hydroxylamines and hydroxyamates.<br>References Magin, D.F., et al.: J. Chromatogr., 178, 219 (1979), Safavy, A., et al.: Bioconjug. Chem., 13, 327 (2002),<br></p>

<p>Applications 9-cis-Retinyl Stearate-d5, is the labeled analogue of 9-cis-Retinyl Stearate (R275600), a fatty acid ester of Retinol isomer, found mainly in the retina.<br>References Bridges, C.D.B., et al.: Methods Enzymol., 81, 463 (1982),<br></p>

<p>Applications Epolamine is a very useful synthetic intermediate. It is a reagent used to synthesize Diclofenac Epolamine (D436470) which is a diclofenac salt with greater water solubility and better cutaneous absorption properties than other commonly used forms of the drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Serafini, G., et al.: Clin. Drug Invest., 32, 41 (2012); Fini, A., et al.: Eur. J. Pharm. Biopharm., 38, 66 (1992)<br></p>

<p>Applications 1,3,5-Trimethylhexahydro-1,3,5-triazine (CAS# 108-74-7) is a useful research chemical compound.<br></p>

<p>Stability Hygroscopic<br>Applications 4-(Methylsulfonyl)benzaldehyde has been used in the preparation of arylidene-thiazolidinedione derivatives for the treatment of type 2 diabetes.<br>References Faine, L.A., et. al.: Curr. Med. Chem., 18, 3351 (2011)<br></p>

<p>Applications Benzyl Glycolate was utilized as a potential moiety for the preparation of phosphonate dipeptides as potential inhibitors of VanX.<br>References Jia, C., et al.: BIoorg. Med. Chem. Lett., 22, 482 (2012);<br></p>

<p>Applications 3-Hydroxynaphthalene-2,7-disulfonic Acid Disodium Salt, is used in analytical studies for detecting organic explosives and propellants by fast liquid chromatography quadrupole time-of-flight mass spectrometry.<br>References DeTata, D., et al.: Forensic Sci, Int., 233, 63 (2013); Mathis, J., et al.: J. Chromatogr. A., 988, 107 (2003)<br></p>

<p>Applications Nonanoyl Chloride is used in the synthesis of immunosuppressants involving 2-aminoethanols and aminopropane-1,2-diols. Also used in the synthesis of Vanilloids with antinociceptive and antiinflammatory compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kiuchi, M. et al.: J. Med. Chem., 43, 2946 (2000); Janusz, J. et al.: J. Med. Chem., 36, 2595 (1993);<br></p>

<p>Applications Diethylamine Hydrochloride is a secondary amine and a precursor of Atrazine (A794600). It is used as a reactant if the production of pesticides, dyes and pharmaceutical compounds.<br>References Raghuram, P. et al.: Chromatograph., 71, 963 (2010); Smith, D. &amp; Crowley, D.: FEMS Microbiol. Ecol., 58, 271 (2006); Asiri, A.: Dyes and Pigments., 42, 209 (1999); Rijhsinghani, K. et al.: Canc. Det. Prev., 5, 283 (1982)<br></p>