Building Blocks

<p>Stability Light Sensitive<br>Applications 4-Bromo-1-butene is a brominated alkene used as a reagent in organic synthesis.<br></p>

<p>Applications N4-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-[5-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]pentyl]-N1-hydroxybutanediamide, is a bifunctional chelator.<br></p>

<p>Applications 1,4-Dithiane has been studied to be used as a way for more efficient rechargeable iron-​air and nickel-​iron batteries through small addition of organo-sulur compounds to metal electrodes.<br>References Yang, B., et al.: Energy Environ. Sci., 7, 2753-63 (2014);<br></p>

<p>Stability Moisture Sensitive<br>Applications Ethyl Malonyl Chloride is used as a reagent in the synthesis of novel thiadiazoloacrylamide analogs as inhibitors of dengue-2 virus NS2B/NS3 protease. Ethyl Malonyl Chloride is also used as a reagent in the synthesis of quinolone-benzylpiperidine derivatives as acetylcholinesterase inhibitors and antioxidant hybrids for Alzheimer disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, H., et al.: Bioorg. Med. Chem., 22, 6344 (2014); Pudlo, M., et al.: Bioorg. Med. Chem., 22, 2496 (2014)<br></p>

<p>Applications 1-Bromo-2-butyne is used in the synthesis of six to eight annulated ring compounds in reactions with indoles. It is also used in the preparation of Pseudopterane (+/-)-Kallolide B, a marine natural product.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ferrer, C. et al.: Chem. A. Eur. J. et al.: 13, 1358 (2007); Marshall, J. et al.: J. Org. Chem., 60, 796 (1995);<br></p>

<p>Applications 2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Durban, M. et al.: Eur. J. Lipid. Sci. Tech., 105, 633 (2003);<br></p>

<p>Stability Light Sensitive<br>Applications MPEP is a potent and highly selective non-competitive mGlu5a receptor antagonist (1,2). It is also a positive allosteric modulator at mGlu4 receptors.MPEP exhibits anxiolytic and antidepressant properties that may be applicable for treating schizophrenia (3).<br>References (1) Latif-Hemandez, A., et al.: Front Cell Neurosci. 10, 252 (2016)(2) Hikichi, H. et al.: Eur. J. Pharmacol., 639, 99 (2010)(3) Inta, I., et al.: Pharmacopsychiatry. 49, 142 (2016)<br></p>

<p>Applications A powerful complexing agent. A potent acid sphingomyelinase inhibitor.<br>References Marathe, S., et al.: J. Biol. Chem., 273, 4081 (1998), Lang, P., et al.: Nat. Med., 13, 164 (2007), Nara, F., et al.: J. Antibiot., 52, 525 (1999), Szajnman, S., et al.: Bioorg. Med. Chem. Lett., 15, 4685 (2005),<br></p>

<p>Applications 2,5-Dimethylpyrazine is used as a reagent in the synthesis of bone-targeted proteasome inhibitors for multiple myeloma (MM). 2,5-Dimethylpyrazine is also used in the preparation of 3-Methyl-2,5-bis-(2-hydroxyethyl)pyrazine (M295340); a degredation product of Clavulanic Acid (C563750) which is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.<br>References Agyin, J.K., et al.: Bioorg. Med. Chem. Lett., 23, 6455 (2013); Reading, C. and Cole, M.: Antimicrob. Ag. Chemother., 11, 852 (1977); Ball, A.P., et al.: Lancet, 1, 620 (1980); Brogden, R.N., et al. Drugs, 22, 337 (1981); Haginaka, J. et al.: Chem. Pharm. Bull., 33, 218 (1985)<br></p>

<p>Applications Ethyl fluoroacetate is an inhibitor of insect juvenile hormone biosynthesis. It also shows toxic effects against Vibrio fischeri.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Quistad, Gary B., et al.: J. of Agri. and Food Chem., 30(6), 1151-4 (1982);Dawson, D. A., et al.: Archives of Envir. Contam. and Tox., 66(2), 248-258 (2014)<br></p>

<p>Applications Sodium 4-chlorophenoxyacetate (cas# 13730-98-8) is a useful research chemical.<br></p>

<p>Impurity Cefoperazone EP Impurity C<br>Applications N-Methyl-5-tetrazolethiol (Cefoperazone EP Impurity C) is an impurity of Cefoperazone.<br>References Kitson, T., et al.: Biochem. J., 175, 83 (1978), Elenbaas, R., et al.: Clin. Pharmacol. Ther., 32, 347(1982),<br></p>

<p>Applications Sodium Acrylate is the acid form of Acrylic Acid (A191350); which is an antibacterial agent.<br>References Kind, T., et al.: Anal. Biochem., 363, 185 (2007), Spratlin, J., et al.: Clin. Cancer Res., 15, 431 (2009),<br></p>

<p>Applications TETRAHYDROFURFURYL ACRYLATE (cas# 2399-48-6) is a useful research chemical.<br></p>

<p>Applications 3'-Nitroacetophenone is used as a reactant in the synthesis of fluorine based aminothiazoles with antimicrobial activity.<br>References Singh, K., Sharma, P.K.: Int. J. Pharmacy Phamaceut. Sci., 6, 429 (2014)<br></p>