Building Blocks

<p>Stability Moisture Sensitive<br>Applications Thiophosphoryl chloride is a starting material for O-ethyl dichlorothiophosphate synthesis.<br> E0<br></p>

<p>Applications 4,4’-Bis(maleoylamino)azobenzene is a novel azobenzene derivative and a bifunctional crosslinker used for directed modification of proteins and other crosslinking processes.<br>References Hien, L.T., et al.: Russ. J. Bioorg. Chem., 35, 549 (2009); Kamenjicki, M., et al.: Macromolecules., 37, 8293 (2004);<br></p>

<p>Applications 1,3,5-Tribromobenzene-d3 (CAS# 52921-77-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Chloro-5-thiazolecarboxylic Acid (C411465) was studied as one of the metabolites of thiamethoxam, clothianidin, and dinotefuran in mice.<br>References Ford, K., et al.: Chem. Res. Toxicol., 19, 1549 (2006);<br></p>

<p>Impurity Loratadine EP Impurity H<br>Applications N-Carbethoxy-4-piperidone (Loratadine EP Impurity H) is used in the preparation of 3-hydrazinopyridazines as antihypertensive agents as well as γ-carboline derivatives as potential serotonergic agents. N-Carbethoxy-4-piperidone is also an impurity of Loratadine (L469575).<br>References Schenker, E. et al.: Arsneim.-Forsch., 29, 1835 (1979); El-Kader, A. et al.: Mans. J. Pharm. Sci., 6, 1 (1989); Albu, M. et al.: J. Liq. Chrom. Rel. Technol., 32, 2569 (2009);<br></p>

<p>Impurity Mesalazine EP Impurity R<br>Applications A nitrohumic acid which has been shown to bind to Molybdenum to impart fertility to soil and water and is a key element in the activity of nitrogenase.<br>References Merce, A.R. et al.: J Braz. Chem. Soc., 17, 482 (2006); Silverman, F.P. et al.: J. Agric. Food Chem., 53, 9775 (2005);<br></p>

<p>Applications Cinacalcet-d4 Hydrochloride is a labeled analogue of Cinacalcet Hydrochloride (C441800), the (R) enantiomer of Cinacalcet which is used in clinical trial in secondary hyperparathyroidism.<br>References Franceschini N., et al.: Expert Opin. Invest. Drugs, 12, 1413 (2003); Block, G.A., et al.: N. Engl. J. Med. 350, 1516 (2004);<br></p>

<p>Applications Cinchophen and its derivatives can show antipyretic, analgesic, anti-oxidative, and anti-inflammatory properties.<br>References Xu, Bo., et al.: Beijing Yike Daxue Xuebao, 29(5), 438-439 (1997); Ibrahim, S. E., et al.: Mansoura J. Pharm. Sci., 6(2), 19-24 (1990); Mishra, Pradeep., et al.: Indian J. Pharm. Sci., 50(5), 269-271 (1988); Kononenko, L. I., et al.: Zhurnal Analiticheskoi Khimii, 30(9), 1716-19 (1975)<br></p>

<p>Applications 3-(Methylamino)propanoic acid HCl<br></p>

<p>Stability Light Sensitive<br>Applications N,N'-Di(1,3,4-thiadiazol-2-yl)methanediamine inhibits DNA and RNA syntheses by mouse embryo cells.<br>References Tsukamoto, K., et. al.: Cancer Res., 35, 2631 (1975)<br></p>

<p>Applications An intermediate for the synthesis of Norharmane.<br>References Peifer, C., et al.: J. Med. Chem., 50, 1213 (2007),<br></p>

<p>Applications 3-Iodobenzoic Acid (cas# 618-51-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Methylenepiperidine Hydrochloride is a building block that can be coupled with aryl halides via Suzuki cross-coupling to give benzyl piperidines and related compounds.<br>References Vice, S., et al.: J. Org. Chem., 66, 2487 (2001);<br></p>

<p>Applications Pentafluorobenzoic acid (cas# 602-94-8) is a useful research chemical.<br></p>