Building Blocks

Versatile small molecule scaffold

<p>2-Ethoxy-1H-indole is a synthetic, nucleophilic compound that has been shown to be an effective hydrogenation catalyst. The biological properties of 2-ethoxy-1H-indole have been studied in both animals and humans. In rats, this compound has shown to be an effective analgesic and antiinflammatory agent with few side effects. 2-Ethoxy-1H-indole also has shown efficacy in the treatment of Parkinson's disease in animal models. This drug can be used as a precursor for a variety of compounds including carboximidamides, enecarbamates, amines, or sulfoxides. It is also possible to control the stereocontrol of 2-ethoxy-1H-indole by using chiral reagents or by converting it to its chiral counterpart (2-(2'-ethoxy)-1H-indole).</p>

<p>Versatile small molecule scaffold</p>

<p>Azacycloundecan-2-one is a ring-opening polymerization monomer that exhibits good solubility in organic solvents. It is used as the precursor to polyamides and polymeric matrices. Azacycloundecan-2-one has been shown to form a film with a high degree of viscosity and excellent mechanical properties, which are desirable for films in the food industry. Ring opening polymerization of azacycloundecan-2-one can be achieved by using magnesium salts or diacids as catalysts. The lactam ring structure of azacycloundecan-2-one provides reactive sites for reactions with other compounds, such as amines, alcohols, phenols, and carboxylic acids.</p>

<p>2-(2-Methyl-5-nitro-1H-imidazol-1-yl)acetic acid is an antimicrobial agent that inhibits the growth of bacteria by oxidation. It has been shown to be effective against protozoan parasites and has a good activity against Gram-positive bacteria. The main metabolic pathway for 2-(2-Methyl-5-nitro-1H-imidazol-1-yl)acetic acid is hydrolysis by hydrochloric acid, with a minor route involving hydroxy metabolite formation. This drug also acts as a prodrug for antipyrine, which inhibits bacterial growth via inhibition of protein synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,5-Dimethoxy-4-methylbenzaldehyde is a phenylacetic compound that is found in the fructus of plants. It has been shown to have tumor necrosis factor (TNF) and phenolic properties. This molecule also stimulates the inflammatory process by inducing pro-inflammatory cytokines such as TNF-α and IL-1β. 3,5-Dimethoxy-4-methylbenzaldehyde has been found to inhibit the growth of various bacteria, including methicillin resistant Staphylococcus aureus isolates, when used at concentrations of 0.001%.</p>

<p>Versatile small molecule scaffold</p>

<p>1-(Quinolin-2-yl)ethanone is an inhibitor of proteolytic enzymes. It is a triazolopyrimidine that binds to the active site of proteases, thereby inhibiting their activity. 1-(Quinolin-2-yl)ethanone has been shown to be effective against viruses such as herpes simplex virus and Streptococcus faecalis, and bacterial infections such as streptococcus faecalis and Staphylococcus aureus. 1-(Quinolin-2-yl)ethanone also inhibits the production of matrix metalloproteinases, which play an important role in tumor development, by binding to the zinc ion in the enzyme's active site. This compound can also be used synergistically with copper chloride or hydrochloric acid to inhibit protease activity.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>1-Methyl-2-benzimidazolinone is a synthetic compound that has been shown to be cytotoxic to cancer cells. It binds to metal ions and forms reactive intermediates, which are able to react with nucleophiles in cellular macromolecules. The reaction mechanism of 1-methyl-2-benzimidazolinone is similar to the reaction of picolinic acid with metal hydroxides. The heteroarylations of this compound have also been studied using chemical ligation, and it has been found that the d4 receptor may play a role in its cytotoxicity.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Bromo-5-chloro-4-hydroxybenzaldehyde (3BCHA) is a phenolic compound that has been used in the synthesis of new drugs. 3BCHA is produced by the ozonation of 2,6-dichlorophenol and subsequent reactions with sodium hydroxide and hydrogen peroxide. The production of 3BCHA can be monitored using gas chromatography/electron spray ionization mass spectrometry (GC/ESI MS). 3BCHA can be synthesized in two ways:</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>