Building Blocks

<p>Versatile small molecule scaffold</p>

<p>2,1-Benzothiazole-3-carboxylic acid is a chlorinated compound with a methyl group. It is a hydrolysis product of DDT and exhibits functional and chemical properties similar to those of thionyl chloride. 2,1-Benzothiazole-3-carboxylic acid has been shown to be highly toxic to rats and rabbits, but not to mice.</p>

Versatile small molecule scaffold

<p>Acetochlor is a herbicide that belongs to the class of chloroacetanilides. It has been shown to inhibit the activity of enzymes such as polyphenol oxidase and peroxidase in plants. Acetochlor also inhibits microbial growth, but its mechanism of action is not known. The compound has been shown to be toxic to aquatic organisms and may have significant cytotoxicity in mammalian cell cultures. Acetochlor has been found to be an effective disinfectant for wastewater treatment and has been used in polymerase chain reactions (PCR). Acetochlor is also used as a herbicide for control of weeds and grasses.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-[4-(2-Propynyloxy)phenyl]-1-ethanone is a quinine derivative with a bathochromic shift. It has been shown to undergo cycloadditions, photophysical, and supramolecular reactions in the presence of other molecules. 1-[4-(2-Propynyloxy)phenyl]-1-ethanone shows luminescent properties under optical microscopy and shifts from red to blue when it is irradiated. The compound can also be used as an optical probe for studying the mechanism of drug release in vitro.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Methyl 3-hydroxy-2-methylbutanoate is a chiral compound that can be found in wine. The enantiomers of this compound can be distinguished using a variety of analytical methods. These include chromatographic methods, such as the use of postharvest and solid phase microextraction to separate isomers, as well as spectrometric and mass spectrometric analysis. Methyl 3-hydroxy-2-methylbutanoate has been detected in wines by these methods and is believed to contribute to wine flavor.</p>

<p>1-Phenyl-1H-1,2,3-triazole-4-carbaldehyde (phenyltriazole) is a heterocyclic compound that has been synthesized as a potential drug for the treatment of malaria. The equilibrium between the two isomers is controlled by the rate of thermal isomerization. The dimethyl sulfoxide and nitrile functional groups are responsible for this process. Phenyltriazole has been shown to have antiplasmodial activity in vitro against parasites resistant to chloroquine and pyrimethamine, as well as in vivo against chloroquine resistant strains. This molecule also inhibits growth of Mycobacterium tuberculosis in cell culture and has been shown to be effective against other bacterial strains that are resistant to standard antibiotics. Phenyltriazole binds to DNA gyrase, an enzyme involved in DNA replication and repair, which results in inhibition of RNA synthesis and protein synthesis, leading</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(1H-Indol-5-yl)acetic acid is a lipogenic agent that is used in the treatment of cancer. It binds to nuclear hormone receptors, which regulate lipid biosynthesis. 2-(1H-Indol-5-yl)acetic acid has been shown to inhibit the growth of human bladder cancer cells and increase the uptake of fatty acids by these cells. This agent also has anti-inflammatory properties and causes an increase in reactive oxygen species in microglia, which are immune system cells found in the brain. 2-(1H-Indol-5-yl)acetic acid has been shown to have cytotoxic effects on mammalian cells, but not on bacteria or yeast. 2-(1H-Indol-5-yl)acetic acid may be administered intravenously or intraperitoneally.</p>