Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Vinylnicotinic acid methyl ester belongs to the group of antimicrobial agents. It is a chemical compound that has been shown to be effective against cervical cancer and may have potential as an anticancer drug. 5-Vinylnicotinic acid methyl ester inhibits the growth of human chorionic gonadotropin (HCG) in women, which is a hormone necessary for ovulation and pregnancy. This compound also inhibits the growth of viruses, such as herpes simplex virus type 1 (HSV-1), and bacteria, such as dittrichia sp., which causes inflammation of the throat. 5-Vinylnicotinic acid methyl ester has also been shown to inhibit protein synthesis in human osteosarcoma cells at low concentrations, but not at high concentrations.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Formyl-3-hydroxynaphthalene-2-carboxylic acid (4FHN) is an antibacterial agent. It is bacteriostatic and has been shown to be effective against gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa, but not against gram-positive bacteria such as Staphylococcus aureus. 4FHN was found to inhibit the growth of both gram-positive and gram-negative bacteria by binding to the ribosomal RNA in the bacterial cell wall, thereby inhibiting protein synthesis and cell division. 4FHN also shows antimicrobial activity due to its ability to form stable hydrazones with nucleophilic centers in the bacterial cell wall. These compounds react with cellular macromolecules, leading to cell death.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Bromo-6-hydroxypyrimidine-4-carboxylic acid is a homologous organic acid that is used as a pharmaceutical preservative. It is most commonly found in acidic pharmaceutical formulations. 5-Bromo-6-hydroxypyrimidine-4-carboxylic acid inhibits the growth of bacteria and fungi by acting as an enzyme inhibitor. The inhibition of enzymes such as lactamase, which breaks down the lactam ring in penicillin, prevents bacterial and fungal growth by preventing them from breaking down their natural cell walls. 5-Bromo-6-hydroxypyrimidine-4-carboxylic acid has also been shown to have potent anticancer activity in the lab setting, although the clinical significance of this has not yet been determined.</p>

<p>Versatile small molecule scaffold</p>

<p>3-Chloro-N-methyl-2-nitroaniline is an antibiotic that belongs to the group of quinolone antibiotics. It has a broad spectrum against Gram-positive and Gram-negative bacteria, including methicillin resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. 3-Chloro-N-methyl-2-nitroaniline binds to bacterial DNA gyrase and topoisomerase IV, as well as human DNA gyrase and topoisomerase II, inhibiting their activity. This leads to cell death by interfering with the production of proteins vital for cell division. The optimal parameters for this drug have been found using isothermal titration calorimetry on the enzyme gyrase in the presence of different concentrations of 3CMA. Pharmacological targets for this drug include DNA gyrase and topoisomerase IV.</p>

<p>N-(Carbamothioylamino)furan-2-carboxamide is a chemical compound that has been used as a liver protectant and to treat calcium deficiencies. The calcium salt of the drug is prepared by mixing anhydrous ethanol with calcium chloride and adding pyridine dropwise. Upon refluxing, the mixture is cooled and then evaporated under vacuum to yield the desired product.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(2-Methylphenyl)-2-sulfanyl-4,5-dihydro-1H-imidazol-5-one is a cross linking agent that is used in the production of polyurethanes. It is derived from 2,2'-oxydiethanol and can be used as a polymerization catalyst for polyurethane resins. 1-(2-Methylphenyl)-2-sulfanyl-4,5-dihydro-1H-imidazol-5 -one has been shown to have antibacterial properties against gram positive bacteria such as Staphylococcus aureus and Streptococcus pneumoniae. The antibacterial activity was attributed to its ability to form covalent bonds with carboxylic acid groups on the bacterial cell wall.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-(1,3-Benzothiazol-2-yl)-2-methoxypropanoic acid is a versatile compound that exhibits various characteristics and applications. It forms hydrogen bonds with other molecules, making it useful as an intermediate in the synthesis of compounds like blonanserin. Additionally, it can act as a chlorinating agent in the presence of suitable catalysts.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Iodo-4-methoxybenzaldehyde is a chiral compound that can be synthesized through an intramolecular, stereoselective cyclic annulation reaction. The key step in this process is the arylation of 2-iodo-4-methoxybenzaldehyde with ethyl bromide. This compound can also be synthesized by reacting 2-iodobenzoic acid with formaldehyde in the presence of a base. In addition, 2-Iodo-4-methoxybenzaldehyde can be produced by the sequence of nitrogen substitution and tricyclic annulation.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>