Building Blocks

<p>Applications Used in the preparation of Mepivacaine (M225060) metabolites as well as pyrrolizidine derivatives with antiarrhythmic activity.<br></p>

<p>Applications 3,4,5-Trimethoxybenzoyl Chloride is used as a reagent in the synthesis of 2-methyl-8-(3,4,5-trimethoxybenzamido)-1,2,3,4-tetrahydroisoquinoline and its analogs which display great antihypertensive activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mathison, I.W., et al.: J. Med. Chem., 16, 332 (1973)<br></p>

<p>Applications 2-sec-Butylphenol is a substance used in checking the effect of different enhancers on transdermal permation of insulin. It also acts as one of the substances used as models, which are helpful for aiding screening and development of androgenic compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yerramsetty, K. M., et al.: Int. J. Pharm., 398, 83 (2010); Jia, Y., et al.: isuanji Yu Yingyong Huaxue, 24, 1469 (2007)<br></p>

<p>Applications 2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols. 2-Hydroxy-5-methoxyacetophenone is also used to prepare substituted chromanone and chromone derivatives as sirtuin 2-selective inhibitors.<br>References Baker, W., et al.: J. Chem. Soc., 2303 (1948);Friden-Saxin, M., et al.: J. Med. Chem., 55, 7104 (2012)<br></p>

<p>Applications 3-Nitrophenylboronic Acid is a general reagent the preparation of carbon coated copper nanoparticles and nanowires for usage in Suzuki cross coupling reactions. Also it has been used in the synthesis of oxygenated cabazoles.<br>References Mukherjee, N. et al.: Can. J. Chem., 95, 51 (2017); Kumar, K. et al.: ChemistrySelect., 1, 601 (2016);<br></p>

<p>Applications 3,4,5-Trimethoxytoluene is a reagent for oxadiazolylindazole sodium channel modulators which are neuroprotective toward hippocampal neurons.<br>References Clutterbuck, L. A., et al.: J. Med. Chem., 52, 2694 (2009);<br></p>

<p>Applications 3-Hydroxypropionitrile (cas# 109-78-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 8-Bromooctan-1-ol (cas# 50816-19-8) is a useful research chemical.<br></p>

<p>Applications 2,3-Dimethoxybenzoic acid<br></p>

<p>Applications (R,S)-1-(2-Nitrophenyl)ethanol (cas# 3205-25-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Methylamino-1,2-propanediol (cas# 40137-22-2) is a useful research chemical.<br></p>

<p>Applications 1-Bromo-4-phenylbutane<br></p>

<p>Applications Phenylsuccinic Acid (cas# 635-51-8) is a useful research chemical.<br></p>

<p>Applications A propargyl derivative used in the synthesis of substituted carbocyclic aromatic compounds and pharmaceutical compounds.<br>References Takahashi, H. et al.: J. Org. Chem., 74, 3632 (2009); Ding, F. &amp; Jennings, M.: J. Org. Chem., 73, 5965 (2008)<br></p>

<p>Applications N,N-DIMETHYLFORMAMIDE DINEOPENTYL ACETAL (cas# 4909-78-8) is a useful research chemical.<br></p>

<p>Applications 1-Bromodecane is used to react with Mg to prepare Grignard reagents which play an important role in formation of carbon-carbon bond. It is also used in preparation of biodegradable cationic gemini surfactants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rogers, R., et al.: J. Org. Chem., 39, 857 (1975); Talaba, P., et al.: J. Carbohyd. Chem., 16, 573 (1997); Jain, T., et al., J. Mater. Chem. C: Materials for Optical and Electronic Devices, 2, 994 (2014)<br></p>

<p>Applications 3-Bromo-2-cyanopyridine (cas# 55758-02-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Reagent used in the preparation of many pharmaceutically active compounds such as antiulcer agents, antitumor agents, antibiotics and anxiolytics.<br>References Colabufo, N., et al.: J. Med. Chem., 51, 7602 (2008), Manfroni, G., et al.: Bioorg. Med. Chem. Lett., 19, 714 (2009),<br></p>

<p>Applications Diethyl 2-n-Butylmalonate is used as a reagent in the synthesis of 2,5-dihydropyrrole formyl hydroxyamino derivatives as peptide deformylase inhibitors against drug-resistant bacteria.<br>References Yang, S., et al.: Eur. J. Med. Chem., 86, 133 (2014); Shi, W., et al.: Bioorg. Med. Chem. Lett., 20, 3592 (2010)<br></p>

<p>Applications Diethyl Butylethylmalonate-d5 is the isotope labelled analog of Diethyl Butylethylmalonate, a derivative of Diethyl 2-n-Butylmalonate (D443880) which is a reagent in the synthesis of 2,5-dihydropyrrole formyl hydroxyamino derivatives as peptide deformylase inhibitors against drug-resistant bacteria.<br>References Yang, S., et al.: Eur. J. Med. Chem., 86, 133 (2014); Shi, W., et al.: Bioorg. Med. Chem. Lett., 20, 3592 (2010)<br></p>

<p>Applications Methyl β-Resorcylate, is a building block used for the synthesis of different pharmaceutical compounds. It can be used for the synthesis of series of CCR1 antagonists based upon spirocyclic compounds.<br>References Hossain, N., et al.: Bioorg. Med. Chem. Lett., 23, 3500 (2013);<br></p>

<p>Applications Diethyl Benzylmalonate (cas# 607-81-8) is a compound useful in organic synthesis.<br></p>

<p>Applications (cas# 1993-11-08) is a useful research chemical.<br></p>

<p>Applications α-Chlorophenylacetyl Chloride is a reagent used for dehydrohalogenation of ketones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brady, W.T., et al.: J. Org. Chem., 45, 3525 (1980); Brady, W.T., et al.: J. Org. Chem., 45, 2025 (1980);<br></p>

<p>Applications 3-(Chloromethyl)pyridine Hydrochloride has been used as a reactant for the synthesis of (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-one derivatives as Polo-like kinase 4 (PLK4) inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laufer, R., et. al.: J. Med. Chem., 56, 6069 (2013)<br></p>

<p>Applications Dichloroacetic Acid Methyl Ester is used in the preparation of telechelics and block copolymers through living radical polymerization.<br>References Keul, H., et. al.: Macromol. S., 19, 1 (1971)<br></p>

<p>Stability Moisture Sensitive<br>Applications Triethyl orthopropionate is used as a starting material in the synthesis of Triethyl orthoacrylate. Triethyl orthopropionate is also commonly used in Claisen rearrangement reactions that yield γ,δ-unsaturated esters.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ghosh, A. &amp; Moon, D.: Org. Lett., 9, 2425 (2007); Ito, H. &amp; Taguchi, T.: Tetrahedron Lett., 38, 5829 (1997); Sarkar, D., et al.: Tetrahedron Lett., 50, 1431 (2009)<br></p>

<p>Applications Dibenzyl Hydrogen Phosphate (cas# 538-60-3) is a compound useful in organic synthesis.<br></p>

<p>Applications p-Vinylguaiacol-d3 is the isotope labelled analog of p-Vinylguaiacol (V424960); an aromatic substance, one of the compounds responsible for the natural aroma of buckwheat, and also one of the major pyrolytic products of (E)-N-[(4-hydroxy-3-methoxy)-phenethyl]-3-[(3-methoxy-4-O-β-D-glucopyranosyloxy) phenyl] acrylamide; a new gycloside in tobacco.<br>References Janes, Damjan., et al.: Food Chem., 112(1), 120-124 (2009); Zhou, Rong., et al.: Yancao Keji, (7), 34-36, 42 (2013)<br></p>

<p>Applications 3-(Hydroxymethyl)-4-nitrophenol (cas# 60463-12-9) is a useful research chemical.<br></p>

<p>Applications Phenylmalonic Acid Mono-5-indanyl Ester is an intermediate in the synthesis of Indanylcarbinicillin (S635000), an compound shown to reduce blood pressure in mammals and also has been used as a β-lactam antibiotic.<br></p>

<p>Applications Dibenzyl azodicarboxylate is a reagent used in the synthesis of Minocycline-d6 (M344797). Minocycline-d6 is a labeled second generation tetracycline antibiotic. Antibacterial.<br>References Zbinovsky, V., et al.: Anal. Profiles Drug Subs., 6, 323 (1977); Oringer, R.J., et al.: J. Periodontol., 73, 835 (2002)<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications 1,4-Bis(diphenylphosphino)butane is a catalyst precursor used in organic synthesis such as the preparation of phenanthrothiazoles.<br>References Shi, X. et al.: J. Org. Chem., 82, 3886 (2017);<br></p>

<p>Applications A metabolite of Tryptophan-niacin.<br>References Yuyama, S. et al.: Adv. Exp. Med. Biol. 294, 475 (1991).<br></p>

<p>Applications Hydrochloride salt of N-(β-Chloroethyl)piperidine is used in the inhibition of sickle-cell hemoglobin.<br>References Stubbins, J. et al.: Eur. J. Med. Chem., 14, 219 (1979);<br></p>

<p>Applications Trimethylboroxin is used in a diverse array of areas, including as a polymerization additive. Trimethylboroxin is also used in the preparation of CBS catalysts for asymmetric reductions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gilmore, N., et al.: Tetrahedron Asy., 14, 2115 (2003); Najera, C., et al.: Adv. Synth. Catal., 346, 1798 (2004);<br></p>

<p>Applications 3-Mercaptophenol is a versatile reactant used in the study of mechanism and catalysis of the native chemical ligation reaction. It was also used as a reactant in the synthesis and biological evaluation of HSP90 inhibitors based on molecular dynamic calculated conformational analysis of radicicol and its analogs.<br>References Moulin, E., et al.: J. Am. Chem. Soc., 127, 6999 (2005); Johnson, E., Kent, S.: J. Am. Chem. Soc., 128, 6640 (2006);<br></p>

<p>Applications Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Colby, J., et al.: Biochem. J., 165, 395 (1977), Damani, L., et al.: Xenobiotica, 12, 527 (1982), Balzarini, J., et al.: J. Antimicrob. Chemother., 55, 135 (2005),<br></p>

<p>Applications Myristoyl Chloride is a building block that has been used to form esters on rubber wood. Esterification reduces crystalinity of wood and reduces light0induced color changes (phot-yellowing ) at wood surfaces. Myristoyl Chloride has also been used in the modification of isophalate-PEG copolymers to make amphiphilic copolymers as nanocarriers for drug delivery.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Salla, J., et. al.: J. Wood Chem. Tech. , 32, 121 (2012); Gupta, B., et. al.: J. Macromol. Sci. Pure, 48, 1009 (2011)<br></p>

<p>Applications Ethyl Cyano(ethoxymethylene)acetate is an intermediate in the synthesis of anti-inflammatory agents with gastroprotective effect in rats.<br>References Karoui, A., et al.: Med. Chem. Res., 23, 1591 (2014);<br></p>

<p>Applications Reagent used to conduct (Methoxymethoxy)methyl additions<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>