Building Blocks

<p>Applications 1-Phenyl-pyrazole 4-pyruvic Acid is a derivative of N-Phenylpyrazole, a reactant in the synthesis of candesartan cilexetil(C175580), an ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive.<br>References Seki, M. et. al: ACS Catalysis, 4, 4047 (2014); Shibouta, Y., et al.: J. Pharmacol. Exp. Ther., 266, 114 (1993; Ogihara, T., et al.: Clin. Ther., 16, 74 (1994)<br></p>

<p>Applications o-Tolyl-d7 Isocyanate (CAS# 1219802-73-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3,5-Dichloropyridine (cas# 2457-47-8) is a compound useful in organic synthesis.<br></p>

<p>Applications (2,4-Dichlorophenoxy-d3)acetic-d2 Acid (CAS# 352438-69-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4,6-Dichloro-5-nitropyrimidine (cas# 4316-93-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Triethylamine Hydrochloride is a hydrochloride salt of triethyllamine (T775740). Triethylamine is used as a competing base for the separation of acidic basic and neutral drugs by reverse-phased high-performance liquid chromatography (HPLC). Triethylamine induces visual disturbances (such as foggy vision) in humans, and is also used in industry as a quenching agent in the ozonolysis of alkenes (e.g. (E)-2-Pentene [P227315]). Triethylamine is used in the purification of drugs which are pharmacologically or chemically similar through separation in reverse-phase HPLC (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References 1. Akesson B. et al.: Int Arch Occup Environ Health. 1986;57(4):297-302. 2. Roos RW. et al.: J Chromatogr. 1986 Dec 24;370(3):403-18.<br></p>

<p>Applications Methyl-4-Chloro-7-methoxyquinoline-6-carboxylate is used pharmaceutically for treating infection after burns. It is also used as reagents in the preparation of naphthamides as inhibitors of vascular endothelial growth factor (VEGF) receptor tyrosine kinase.<br>References Zhang, M. et al.: Faming Zhuanli Shenqing (2016), CN 105601566 A 20160525; Harmange, J., et al.: J. Med. Chem., 51, 1649 (2008)<br></p>

<p>Applications Pyrrole-2-carboxylic Acid is a reagent used in the synthesis of potent small molecule inhibitors of severe acute respiratory syndrome (SARS) coronavirus. Also used in the synthesis of [2,3-c]pyridine-7-one scaffolds.<br>References Jacobs, J. et al.: 56, 534 (2013); Nechayev, M. et al.: Mol. Div., 16, 749 (2012);<br></p>

<p>Applications 1,2-Dimethoxybenzene-d10 (CAS# 362049-43-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Sodium Octanoate-d15 (CAS# 56408-90-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Phenylpyridine is a useful synthetic intermediate. 4-Phenylpyridine has been shown to induce inhibition of mitochondrial respiration in mice.<br>References Aiuchi, T. et al.: Neurochem. Int., 12, 525 (1988); Rapoport, H. et al.: JACS, 74, 6293-6294 (1952); Hoppel, C. et al.: Biochem. Biophys. Res. Comm., 148, 684 (1987);<br></p>

<p>Stability Moisture Sensitive<br>Applications A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters.<br>References Perich, J.W., et al.: Synthesis, 142 (1988)<br></p>

<p>Applications Di-tert-butyl iminodicarboxylate is a protected amine group that is used to prepare conformationally constrained spirocycles as CCR1 antagonists.<br>References Houssain, N., et al.: Bioorg. Med. Chem. Lett., 23, 1883 (2013);<br></p>

<p>Applications 3-Methylcrotonyl-L-carnitine-d3 HCl (N-methyl-d3) is a useful isotopically labeled compound<br></p>

<p>Applications 1-Pyrrolidinebutyric Acid Hydrochloride is used in biological studies in the preparation of betaine analogs of mildronate as inhibitors of γ-butyrobetaine hydroxylase, and crystal structures of BBOX-inhibitor complexes.<br>References Tars, K., et al.: J. Med. Chem., 57, 2213 (2014);<br></p>

<p>Applications 4-Chlorobenzoyl Chloride is used as a promoter in the synthesis of α-aminonitriles. It is also used as a derivatization agent and self-assembling dipole molecule to improve hole injection in conjugated polymers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hu, Xiaochun., et al.: J. Organomet. Chem., 705, 70-74 (2012); Simeonov, Svilen P., et al.: Am. J. Anal. Chem., 1(1), 1-13 (2010); Hu, Bao-xiang., et al.: Zhejiang Gongye Daxue Xuebao 35(1), 22-26 (2007); Khodabakhsh, Saghar., et al.: Adv. Funct. Mater., 14(12), 1205-1210 (2004)<br></p>

<p>Applications 1-Phenyl-2,4-pyrrolidinedione is a synthetic intermediate and is obtained from N-Phenylglycine Ethyl Ester and Diethyl Malonate (D444420) which is used in the preparation of barbiturates, artificial flavourings, vitamin B1, and vitamin B6 as well as in perfumes.<br>References Svhreier, P. et al.: J. Agric. Food. Chem., 27, 365 (1979); Opdyke, D.L.J.: Food Cosm. Toxicol., 14, 745 (1976);<br></p>

<p>Applications 1,3,5-Trithiane is an precursor to organosulfur reagents.<br>References Rakhimova, E.B., et al.: Russ. J. Org. Chem., 49, 1300 (2011); Reyes-L., et al.: J. Molec. Stru., 985, 134 (2011);<br></p>

<p>Applications Glyceryl Tri(octadecanoate-d35) (CAS# 125941-88-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Methyl-1H-imidazole-4-carboxylic acid<br></p>

<p>Applications 2-Chloroaniline-d6 (CAS# 1276197-37-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Boc-2-pyrrolidinone is a useful synthetic intermediate. It can be used to prepare highly functionalized N-acyl-2-vinylpyrrolidines by a 4-component Ugi reaction (isocyanide, carbonyl compounds, primary amines, carboxylic acids). It can also be used to synthesize the naturally occurring Maillard flavors via catalytic SeO2 oxidation.<br>References Banfi, L., et al.: J. Org. Chem., 73, 1608 (2008); Fuganti, C., et al.: Tetrahedron, 63, 4762 (2007)<br></p>

<p>Applications Palmityl Myristate is a wax ester of myristic acid used in cosmetics as skin conditioning agents.<br>References Becker, L.C. et al.: Int. J. Toxicol., 29, 162S (2010);<br></p>

<p>Stability Volatile<br>Applications n-Methylhexylamine is used in preparation of Fluoroquinolones as antimalarial agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rao, Y., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Applications n-Hexadecyl-1,1,2,2-d4 Hexadecanoate-16,16,16-d3 (CAS# 1398066-15-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Methylbenzenesulfonamide (cas# 1899-94-1) is a useful research chemical.<br></p>

<p>Applications Glyceryl-d5 Trioctadecanoate (CAS# 55256-03-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl Isocyanoacetate, is used in the Cu-catalyzed, diastereoselective synthesis of oxazolines (O846550).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ideguchi, T., et al.: J. American Chem. Soc., 135, 12568 (2013);<br></p>

<p>Stability Light Sensitive<br>Applications Pheophorbide a is a chlorophyll-related compound studied for it’s anti-tumor &amp; anti-cancer activity.<br></p>

<p>Applications 2,4'-Dibromoacetophenone-2-13C (CAS# 335081-05-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Chlorocyclohexane, is a building block used in various chemical synthesis.<br></p>

<p>Applications 3-Bromo-benzenebutanoic Acid is a reactant used in the preparation of pyrrolo-(di)-benzazocinones via an intramolecular cyclization of N-acyliminium ions formed from 4,4-diethyoxybutyl amides (Erratum)<br>References King, F.D., et al.: Org. Biomol. Chem., 7, 5271 (2009); King, F.D., et al.: Org. Biomol. Chem., 7, 167 (2009)<br></p>