Building Blocks

<p>Applications Myristyl Palmitate is a wax ester of palmitic acid. Wax esters are esters between long chained fatty alcohols and fatty acids. Wax esters have significance in pharmaceutical and cosmetics applications and occur naturally in plants and animals.<br>References Wheatley, V., et al.: Biochem. J., 58, 167 (1954); Shichijo, S., et al.: Biochem. Med., 22, 256 (1979); Robosky, L., et al.: J. Lipid Res., 49, 686 (2008);<br></p>

<p>Applications 1-Bromotetradecane-1,1,2,2-d4 (CAS# 1219798-81-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Bromo-3'-nitroacetophenone is a reagent used the preparation of arylthiazolidinone derivatives which have BRD4 bromodomain inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhao, L., et al.: J. Med. Chem., 56, 3833 (2013);<br></p>

<p>Applications 2-Hydroxy-3-methyl-butanedioic Acid is used as a sole C source when metabolized by soil bacterium; Also, it is an intermediate used in the synthesis of 5-Methyl-2’-deoxy Cytidine-13C,15N2 (M295904), which is an isotopic analog of 5-Methyl-2’-deoxy Cytidine (M295900), a Cytidine (C998300) analog and also an isostere of Thymidine (T412000).<br>References Nakano, H., et al.: J. Biochem., 70, 429-440 (1971); Sabini, E., et al.: J. Med. Chem., 51, 4219 (2008), Sabini, E., et al.: J. Mol. Biol., 378, 607 (2008)<br></p>

<p>Applications 3-Bromothioanisole (cas# 33733-73-2) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Bromothiophene (cas# 1003-09-4) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-[(2-Hydroxyethyl)Amino]Propanoic Acid (cas# 5458-99-1) is a useful research chemical.<br></p>

<p>Applications (2E)-3-(4-Bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2-propen-1-one recently known as NIBR 189, is a selective Epstein-barr virus-induced gene 2 (EBI-2) receptor antagonist, resulting in a modulation of immune responses related to auto-immune diseases.<br>References Gessier, F. et al.: J. Med. Chem., 57, 3358 (2014);<br></p>

<p>Applications Diethyl Ketomalonate (cas# 609-09-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Methylimidazole-d6 (CAS# 1219804-79-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Diethyl 4-oxopimelate<br></p>

<p>Applications 3,5-Dihydroxybenzaldehyde, is a benzaldehyde derivative, that can be used as a building block in the synthesis of more complex structures. It is used in the synthesis of Terbutaline (T109750), which is an important bronchodilator.<br>References Effenberger, F. et al.: J. Org. Chem., 62, 3867 (1997);<br></p>

<p>Applications 2-Bromo-1,3,4-thiadiazole<br></p>

<p>Applications 3-Mercaptopropionic-2,2,3,3-d4 Acid (CAS# 1141488-67-6) is a useful isotopically labeled research compound. It is used for structural proteomics interactions.<br>References Petrotchenko, E., et.al., Mol. Cell Proteomics, 8,273-286,(2009);<br></p>

<p>Applications 2-Chloro-2-methylpropane-2-13C (CAS# 32488-42-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Chloro-2-methylpropane is a starting molecule to carry out nucleophilic substitution reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Eyet, N., et al.: J. Phy. Chem. A., 117, 1136 (2013); Eyet, N., et al.: J. Am. Mass. Spec., 18, 1046 (2007);<br></p>

<p>Applications Dibenzosuberenol is an intermediate in the synthesis of 5H-Dibenzo[a,d]cycloheptene which itself was used in the synthesis of cyclotribenzylenes. Also functions as a calmodulin inhibitor affecting various crucial cellular processes.<br>References Schmuck, C. et al.: Synth., 5, 655 (2002); Lavoie, P.. et al.: J. Neurobio., 17, 681 (1986);<br></p>

<p>Applications 2,4-Difluorobenzoic Acid (cas# 1583-58-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,2-Difluorobenzene is used in electrochemical analysis of transition metal complexes. 1,2-difluorobenzene is also a potent inhibitor of NMDA receptor.<br>References O'toole, T.R. et al.: Inorg. Chem., 28, 3923 (1989); Eger, E.I. et al.: Anesth. Analg., 102, 1397 (2006);<br></p>

<p>Applications 5-Hexynoic Acid<br></p>

<p>Applications Chloromethyl Pivalate is used in the synthesis of oxazolines used in the preparation of imidazolium triflates. Also used in the synthesis of Src Kinase inhibitors used as anti-tumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Glorius, F. et al.: Chem. Comm., 22, 2704 (2002); Hennequin, L. et al.: J. Med. Chem., 49, 6465 (2006);<br></p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-4,5-dimethoxybenzaldehyde is a functional group that can be used as a nucleophile in organic synthesis. It has been shown to react with amines to produce nitro compounds. This functional group also reacts with acidic substances such as malic acid and ethanol extractions, forming chlorinated products. 2-Chloro-4,5-dimethoxybenzaldehyde can be extracted from the surface of plants using piperazine or morpholine.</p>

Versatile small molecule scaffold

<p>2-Amino-benzothiazole-6-sulfonic acid amide is a drug that belongs to the class of anhydrase inhibitors. It has been found to have a potent inhibitory effect on carbonic anhydrase, which is thought to be involved in the pathogenesis of some cancers. This drug has also been shown to have antiviral effects against HIV and Herpes simplex virus type 1, as well as antibacterial activity against Entamoeba histolytica and Giardia lamblia. 2-Amino-benzothiazole-6-sulfonic acid amide has been shown to reduce inflammation by inhibiting immunodeficiency, which may be due to its inhibition of the enzyme carrageenan synthase. The carrageenan synthase enzyme is required for the production of polysaccharides found in red blood cells and microorganisms that are involved in inflammatory processes.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>4-Chloro-3-methoxy phenol is a chemical that belongs to the group of halogenated aromatic compounds. It is a colorless liquid with a sweet odor. 4-Chloro-3-methoxy phenol has been found to be absorbed by humans through inhalation and ingestion. The absorbed dose is dependent on the individual's weight, and the radiation dose depends on the type of radiation used. 4-Chloro-3-methoxy phenol can be synthesized by reacting 2 chloroanisole with chlorine gas in an experimental reaction mechanism. This compound reacts with DNA bases and causes mutations, as well as producing reactive oxygen species that can cause oxidative damage to DNA.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Thiolane-3-carboxylic acid is a heterospirocyclic compound that inhibits HIV-1 reverse transcriptase. Thiolane-3-carboxylic acid is a biologically active metabolite of the anti-HIV drug azidothymidine, which is in turn obtained by the chemical transformation of the urethane intermediate. The structural similarity between this compound and valine has been shown to be due to the presence of a thiobenzoic ring system. The inhibition of HIV-1 replication by this active form has been shown using protease inhibitors, hydroxyethylamine, and alcohols.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>