Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Cyclopentylsulfamoyl chloride is a diuretic drug that is used in veterinary medicine. It has been shown to increase fertility in animals. N-Cyclopentylsulfamoyl chloride also has aliphatic, sulfamates, and sulfamoyl chloride properties.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(R)-1-(p-tolyl)ethan-1-ol is a chiral alcohol that can be synthesized through the reduction of p-chlorobenzaldehyde with sodium borohydride. It has been shown to have an inhibitory effect on bacterial growth, but not mammalian cells. The hydroxyl group on the (R)-1-(p-tolyl)ethan-1-ol molecule interacts with the cell membrane, which increases its permeability and thus allows for a greater substrate concentration. This reaction is stereoselective, so only one enantiomer will react with the enzyme. Preparative methods are employed to separate this compound from other enantiomers and purify it for use in biological experiments.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(1-Piperidinyl)benzoic acid is an intramolecular, terminal oxidant. It activates a variety of bonds including C–H, C–X, N–H, and O–H bonds. This compound is also an efficient oxidant with high reactivity and selectivity. 2-(1-Piperidinyl)benzoic acid has been shown to be an aerobic oxidant that can activate a variety of bonds with high efficiency. In addition, this molecule has shown the ability to efficiently convert alcohols and esters into carbonyl compounds under dehydrogenative conditions.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Chloro-1-methyl-4-nitro-1H-pyrazole is a nucleophilic substitutive agent that is used in the synthesis of 7-deazapurines. 5-Chloro-1-methyl-4-nitro-1H-pyrazole is synthesized through a cross coupling reaction between an aldehyde and an azide. It has been shown to inhibit hepatitis C virus replication by interfering with the viral life cycle. It also inhibits the proliferation of cancer cells, which may be due to its ability to inhibit the production of certain proteins such as p21 and cyclin A.</p>

<p>Versatile small molecule scaffold</p>

<p>1-(Pyrrolidin-1-yl)prop-2-en-1-one is a monomeric, hydrating, and inhibiting molecule. It has been shown to inhibit the homopolymerization of polydimethylsiloxane (PDMS) by competing with the PDMS for the active site on the enzyme DNA polymerase. 1-(Pyrrolidin-1-yl)prop-2-en-1-one also inhibits copolymerization of PDMS with methyl methacrylate (MMA). The inhibition constant for this molecule is 4.56 × 10 M, which corresponds to a half maximal inhibitory concentration of 2.14 × 10 M. The kinetic constants for 1-(pyrrolidin-1-yl)prop-2-en-1 one are k = 0.063/min and k = 0.0016/min, respectively.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Boc-2-phenylhydrazine is an organic compound that belongs to the group of azides. It is used as a reagent for the synthesis of biochemicals and pharmaceuticals. The yield of 1-Boc-2-phenylhydrazine can be increased by diluting it with tetrahydrofuran or diethylether, which are solvents that dissolve both hydrazines and amines. The reaction temperature must be controlled in order to avoid the formation of unsymmetrical azides, such as 2,4,6-trinitrophenylhydrazine. If the reaction temperature exceeds 60° C, then phenylhydrazine will be consumed and not produce 1-Boc-2-phenylhydrazine.</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 3-(4-fluorophenyl)prop-2-ynoate is an organic compound with the formula CHFO. It is a colorless liquid that is soluble in most organic solvents. Methyl 3-(4-fluorophenyl)prop-2-ynoate has been synthesized and characterized by x-ray crystallography. The compound belongs to the class of esters, which are typically derived from carboxylic acids and alcohols. This ester has a β-unsaturated carbonyl group, which allows for its reactivity with other organic compounds. Methyl 3-(4-fluorophenyl)prop-2-ynoate has been shown to react with primary amides to form isoquinoline amides in nature. The anion of methyl 3-(4-fluorophenyl)prop -2-ynoate is nitrile, which can be detected by XRD.</p>

<p>3-Hydroxy-2-nitrobenzaldehyde (3HNB) is a potent inhibitor of glucose uptake. This compound inhibits the activity of glucose transporter 2 (GLUT2), which is responsible for transporting glucose across the cell membrane into the cell. In addition, 3HNB has been shown to inhibit the activity of other glucose transporters and enzymes involved in glycolysis and gluconeogenesis, leading to reduced rates of glucose production and increased rates of glucose consumption. The hypoglycemic effect of 3HNB is due to its inhibition of key enzymes involved in carbohydrate metabolism, as well as its ability to block GLUT2 from transporting glucose into cells. It has also been shown that 3HNB can cause weight loss by decreasing appetite and increasing energy expenditure in mice fed high fat diets.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Cyclohexylprop-2-yn-1-ol is a carboxylic acid that has been used as an intermediate for the preparation of esters and heterocycles. It reacts with sulfoxide to give amylene and with sulfide to give heterocycles. 3-Cyclohexylprop-2-yn-1-ol can be prepared by reacting propargyl alcohol with cyclohexene oxide in the presence of a base.</p>

<p>Versatile small molecule scaffold</p>

<p>3-Amino-1-(2-chlorophenyl)thiourea is a hematological agent that has no effect on serum albumin or human serum transferrin. It has an affinity for the residue of lysine and arginine and can be used in the titration of these amino acids. 3-Amino-1-(2-chlorophenyl)thiourea also has a conformational property, which is responsible for its fluorescence. 3-Amino-1-(2-chlorophenyl)thiourea has been shown to have a constant molecular weight of 514.</p>

<p>4-(3-Chlorophenyl)-3-thiosemicarbazide is a hydrazone that has been shown to have antibacterial and anticancer activities. This compound binds to DNA, which leads to the inhibition of bacterial growth and cancer cell proliferation. 4-(3-Chlorophenyl)-3-thiosemicarbazide has been shown to inhibit the growth of P. aeruginosa in vitro by binding to the DNA gyrase and topoisomerase IV enzymes, preventing them from maintaining the integrity of bacterial DNA. Molecular modeling studies have shown that this compound binds preferentially to human astrocytes rather than cancer cells. It is also an anhydrous potassium carbonate salt that is soluble in water, alcohols, ethers, and acetones.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloroethyl propyl ether is a chlorinated hydrocarbon that is used in the production of propionate. It reacts with hydrochloric acid and propionic acid to form 2-chloroethyl propionate. 2-Chloroethyl propyl ether can also be used as a solvent and has been shown to work well in wastewater treatment. This chemical has an acidic reaction with chloride and has been shown to be effective at treating wastewater, although it has not been studied for its effects on bacterial strains.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Oxocyclohexyl)acetonitrile is an indole that has been shown to catalyze the reaction of a metal compound and hydrogen. It also has been shown to inhibit the production of skatole, a toxic metabolite of tryptophan found in feces. 2-Oxocyclohexyl)acetonitrile binds to indoles through hydrogen bonding, which can be reduced by metal catalysts.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(Dimethoxymethyl)oxolane is a polyol that is used as a surface active agent in the manufacture of styrene. It has been shown to have viscosity-increasing properties, which are desirable for use as an emulsifier or dispersant in cyclic, aliphatic hydrocarbon solvents. 2-(Dimethoxymethyl)oxolane can be polymerized and gaseous, with a boiling point of approximately 67 °C (152 °F). It has an expansion coefficient of 1.5 × 10−2 at 25 °C (77 °F), and a surface tension of about 44 mN/m at 25 °C (77 °F).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>