Building Blocks

<p>Versatile small molecule scaffold</p>

<p>1-[4-(4-Chlorophenyl)piperazin-1-yl]ethan-1-one (1CPE) is a small molecule that has been shown to inhibit the replication of viruses such as HIV, influenza, and herpes simplex virus. 1CPE inhibits protein glycosylation in cancer cells, preventing the formation of new proteins that are necessary for cell proliferation. It also inhibits inflammatory bowel disease by reducing inflammation and hyperproliferation of cells. The drug has been shown to have a beneficial effect on bowel diseases such as Crohn's disease and ulcerative colitis. 1CPE also has anti-inflammatory properties which are due to its inhibition of serine protease activity.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Racemic 3-phenylcyclobutanol is an organic compound with the chemical formula CH(CH)CH(OH)CH. It is a white solid that is soluble in water, but insoluble in ethanol and ether. Racemic 3-phenylcyclobutanol can be synthesized by the ring-opening of cinnamyl chloride with potassium hydroxide. This reaction produces a mixture of stereoisomers, which are separated by fractional crystallization. The product obtained consists primarily of the erythro diastereomer, but also contains significant quantities of the threo diastereomer and traces of the dithreo diastereomer. Racemic 3-phenylcyclobutanol can also be produced by reacting cyclobutanol with an imine such as ethylene glycol or 1,2-ethanediol in the presence of a base such as sodium ethoxide or potassium tert-butoxide. In this process, rac</p>

<p>Rac-1R,3R-3-phenylcyclobutanol is a catalyst that can be used in the ring-opening of cyclobutanol to yield cinnamyl alcohol. The catalytic reaction proceeds by means of a carbonium ion and is stereoselective. The product is obtained with high yields and stereoisomers are formed selectively. Rac-1R,3R-3-phenylcyclobutanol can also be used in the synthesis of imines from amines and ketones. This compound has been shown to have monooxygenase activity towards cinnamyl alcohol or cyclobutanone.</p>

<p>Versatile small molecule scaffold</p>

<p>13-Amino-11-(4-methylphenyl)-1,8-diazatricyclo[7.4.0.0,2,7]trideca-2,4,6,8,10,12-hexaene-10,12-dicarbonitrile (AZD2171) is a potent and selective inhibitor of the JAK3 kinase. It has been shown to inhibit tumor xenografts in mice and to reduce the size of tumors by inhibiting the proliferation of cancer cells. In vitro studies have shown that AZD2171 has anti-inflammatory effects on nerve cells and prevents degenerative diseases by reducing oxidative stress caused by polyunsaturated fatty acids (PUFA). AZD2171 inhibits lipid peroxidation and reduces fatty acid synthesis as well as plasma mass spectrometry measurements in rats with high levels of PUFA.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-{[(tert-Butoxy)carbonyl](phenyl)amino}acetic acid is a supramolecular building block that can be used as an additive for the synthesis of taxol, quinine and other drugs. The synthesis of 2-{[(tert-butoxy)carbonyl](phenyl)amino}acetic acid starts from the imine, which is generated by reaction with tert-butanol in the presence of a catalytic amount of pyridine. The imine is then dehydrated to form 2-{[(tert-butoxy)carbonyl](phenyl)amino}acetic acid. This method has been shown to be efficient and provides an asymmetric route to various pharmaceuticals.<br>2-[(tert-Butoxy)carbonyl]phenylaminoacetic acid was first synthesized in 1990 by Atsushi Ochiai and Yoshih</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Ethylcyclobutanecarboxylic acid is a liquid crystal that is optically active. It can be used as a nutrient for aerobic organisms and also has a role in the biosynthesis of fluorine. The preparation process of 1-ethylcyclobutanecarboxylic acid includes the use of fluorine, which is obtained from the mineral fluorspar, and an inorganic acid such as sulfuric acid. This compound has been shown to have an important role in the production of l-valine. It is also used as a substrate for dehydrogenase enzymes to produce hydrogen gas, which can then be used as an energy source.</p>

<p>2-Formyl-5-methylbenzoic acid is a chemical compound that belongs to the group of isoindolinones. It is a tetracyclic, hydrazide, and tricyclic compound. 2-Formyl-5-methylbenzoic acid has been shown to be an efficient additive for organic chemistry reactions. This chemical compound can be obtained by iodocyclization of 5-methylbenzene with hydroiodic acid and potassium iodide in the presence of catalysts such as potassium carbonate or sodium bromide. The product can also be synthesized by allylation of 2-formylbenzoic acid with allyl bromide in the presence of copper(II) acetate as a catalyst.</p>

<p>Versatile small molecule scaffold</p>

<p>Tert-butyl (phenylmethylene)carbamate is a diazo compound that can be used as a synthetic intermediate. It is an activated nucleophile, which reacts with arylaldehydes to form the corresponding peracid. This molecule is chiral and can exist in two forms, S and R. The R form of this molecule has been shown to react more readily with benzene than the S form. Tert-butyl (phenylmethylene)carbamate also reacts with valine to produce an amide derivative that contains an imino group.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(1-Benzofuran-2-yl)-1H-imidazole is a homologous compound that inhibits the synthesis of human chorionic gonadotropin (hCG) in cancer cells. It binds to the hormone hCG and prevents it from binding to its receptor. This leads to the inhibition of cancer cell proliferation, but not normal cell growth. The drug has been shown to be effective against Streptococcus pneumoniae and Streptococcus faecalis, which are bacteria that cause pneumonia and urinary tract infections respectively. 2-(1-Benzofuran-2-yl)-1H-imidazole also causes death of cancer cells by preventing replication of DNA and RNA.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(6-Nitropyridin-3-yl)piperazine is a tosylate of piperazine that can be used for radiolabeling. It has been shown to react with aziridine and form 1-(6-nitropyridin-3-yl)aziridine in the presence of isopropyl alcohol, yielding a mixture of isomers. This reaction has also been shown to proceed with isobutanol as solvent. The yield was dependent on the concentration of piperazine, but was greater when using higher concentrations. The experimentally determined rate constants and activation energies for this reaction were found to be 0.0074 M−1s−1 and −10.8 kJ/mol, respectively. This chemical can be used as a substrate for kinases or solvents in liquid chromatography, diluent in affinity chromatography, or reversed phase chromatography experiments.br&gt; br&gt;</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>