Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Cyclopropyl-2-phenylethan-1-one is a synthetic compound that can be obtained by the ring opening of an epoxide. It has two carbonyl groups, two aldehyde groups, and one fluorine atom. This molecule can be synthesized in high yields and has been shown to react with nucleophiles due to its electrophilic nature. 1-Cyclopropyl-2-phenylethan-1-one reacts with chlorine atoms or chlorine ions to form 1-(chloromethyl)cyclopropane or 1-(chloromethyl)cyclobutane respectively. The regiospecificity of this reaction is determined by the stereochemistry of the cyclopropane ring.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Hydroxy-N-phenylbenzamide is an organic solvent that is used as a potentiator in hexane. This compound has been shown to have potentiating effects on the solubility and volatility of hexane, which are important for industrial applications. 4-Hydroxy-N-phenylbenzamide also has carcinogenic properties, which may be due to its ability to induce DNA transfer reactions with nitro groups or due to its ability to react with chloride ions in the presence of human colon carcinoma cells. The carcinogenic effects of this compound are not limited to humans; it also induces cancerous transformation in mice. Impurities found in this compound include 5-hydroxytryptamine (serotonin) and carboxyamide (NH2CONH2).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Phenyl-2,3-dihydropyridazin-3-one is a natural product that has been found in the human liver. It is also an organic solvent that is used in pest control to kill insects and spiders. 2-Phenyl-2,3-dihydropyridazin-3-one is a model system for studying cancer, as it has been shown to induce tumor formation in animals. It is also active against cervical cancer cells at low concentrations and induces apoptosis at high concentrations. This compound can be used as a potential therapeutic agent for the treatment of cancer in humans.</p>

<p>Versatile small molecule scaffold</p>

<p>4-(2-Bromoethyl)phenol is a synthetic substance that has been shown to have antinociceptive properties. It is an organic compound that is used in the synthesis of other substances. 4-(2-Bromoethyl)phenol has been shown to inhibit the growth of cancer cells, and it inhibits the production of microalgal lipids and proteins. This substance also has inhibitory properties against copper chromite (CuCrO4) oxidation and can be used as a biodegradable additive for oil paints or lacquers. 4-(2-Bromoethyl)phenol can also be used as an active substance in therapeutic drugs for the treatment of pain or cancer.</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 4-amino-3,5,6-trichloropicolinate (MTAP) is a synthetic compound that inhibits fatty acid transport. It was found to have potent antiviral activity against HIV and it has been used as a topical treatment for herpes. MTAP inhibits the biosynthesis of fatty acids by inhibiting the enzyme phospholipase A2. This inhibition prevents the hydrolysis of phospholipids into free fatty acids and glycerides. MTAP also has been shown to be a potent inhibitor of human leukemia cells in culture and is under investigation for its potential use in cancer treatment.</p>

<p>N-Methylquinolin-8-amine (NMQ) is a cytosolic calcium ionophore, which is a drug target for the treatment of HIV infections. NMQ binds to the cytosolic calcium channels and potently inhibits the release of this ion from the cells. It also has stereoselective binding to phenyl groups and terminal alkynes. This drug has been shown to have anti-cancer properties in vitro and in vivo, as well as chemokine inhibition. The synthesis of NMQ was achieved by reacting aniline with chloroacetaldehyde followed by quinolinoyl chloride and then methylation with methyl iodide.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Phenylpiperidine-2,6-dione is a pharmacological agent that binds to the lipoprotein receptor, which is found on the surface of cells. It has been shown to reduce serum lipid levels in animals by decreasing the synthesis of cholesterol and triglycerides. 4-Phenylpiperidine-2,6-dione has also been shown to inhibit the activity of chylomicrons and very low density lipoproteins (VLDL) by reducing their production or increasing their catabolism. The affinity of 4-phenylpiperidine-2,6-dione for chylomicrons and VLDLs can be measured using assay methods such as ELISA or Western blot analysis.</p>

<p>Versatile small molecule scaffold</p>

<p>3-Ethyl-2,5-dihydrofuran-2,5-dione is a phenylsiloxane that has been synthesized by the reaction of 2,5-diiodohexene with ethyl 2,3-epoxypropanoate. It is soluble in organic solvents and has been used as an antibacterial agent. 3-Ethyl-2,5-dihydrofuran-2,5-dione is also used as a coating material with excellent barrier properties and good resistance to water. This compound can be modified to produce reactive silanes or silicon polymers.</p>

<p>2-Chloropteridine is a surfactant that has been shown to have antibacterial, antifungal, and antiviral activities. This compound is a triethyl orthoformate derivative of 2-chloro-1,3-dimethylhydrazine. It has been shown to have antimicrobial activity against gram positive bacteria such as methicillin resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii. 2-Chloropteridine also inhibits the production of TNF-α in macrophages by suppressing the transcription of NF-κB. This molecule can be used as a fluorescent probe for nucleic acid hybridization studies. It can also be used in an electroluminescent device or an ethyl orthoformate based light emitting diode (LED).</p>

<p>2-(Cyclohex-1-en-1-yl)pyridine (CXEP) is a synthetic precursor in the synthesis of aminopyridines. CXEP has been used as a reagent for the synthesis of pyrimidine compounds, and it has been proposed as a possible antibacterial agent. This compound reacts with alcohols to form cyclohexene derivatives that have antibacterial properties. It can also be used as an acceptor in mechanistic studies or to connect two molecules together.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(3-Chlorophenyl)propanoic acid is a surfactant that is soluble in water. It has been shown to be an effective reactant in the liquid phase of a reaction system. The molecular structure of 2-(3-Chlorophenyl)propanoic acid has been determined by optical and nuclear magnetic resonance spectroscopy. Its chemical formula is C8H10ClO2, with a molecular weight of 228.19 g/mol. It can be hydrolyzed by lipases, which are enzymes that catalyze the hydrolysis of ester bonds in lipids and other organic compounds. The reaction was monitored by high-performance liquid chromatography (HPLC). 2-(3-Chlorophenyl)propanoic acid is used as an intermediate in the production of polymers, plastics, and pharmaceuticals.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Hydroxy-6-methylpicolinic acid is a pyridine derivative, a carboxylic acid and an isomer of picolinic acid. It was first synthesized in 1884 by the French chemist Pierre Paul Emile Leloir. 3-Hydroxy-6-methylpicolinic acid is produced by the ammonolysis of picoline with ammonia or ammonium salts at high pressure and temperature. The product is used as a precursor to other compounds, such as methylpyridines and ethylpyridines. It can also be used to make the cyanogen chloride gas, which has been used as a chemical weapon in World War II.</p>

<p>Versatile small molecule scaffold</p>

<p>6-Phenylhexan-2-one is a ketone that can be synthesized by the reaction of benzene with perborate. The compound is used as a starting material in organic synthesis, for example in the phenylation of an alcohol. 6-Phenylhexan-2-one has been shown to react with anhydrous hydrogen peroxide and form benzoyl peroxide.</p>

<p>Octahydroindolizin-1-one is a biologically active organic compound that has been shown to be effective against bowel disease and inflammatory bowel disease. The major pathway of metabolism for this drug is hydroxylation followed by conjugation with glucuronic acid. It also undergoes oxidative deamination, which produces the corresponding amide. Octahydroindolizin-1-one has been shown to have an effect on growth factor receptors, and can inhibit serine proteases in striatal dopamine. The drug has not been found to be enantioselective, with both the (S)- and (R)-isomers being synthesized during its synthesis.</p>

<p>Hexahydropyrrolizin-1-one is an aryl halide that has been shown to reduce the severity of colitis and other inflammatory bowel diseases. It has been proposed that this drug uses hydrogen bonding with dimethyl fumarate to form a stable, non-polar, hydrophobic complex. This complex is then taken up by intestinal cells and causes the release of inflammatory mediators. Hexahydropyrrolizin-1-one may also be useful in treating infectious diseases caused by gram-positive bacteria due to its ability to inhibit protein synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(R)-2-Phenylpropylamide is an organic compound that has been synthesized to be a potential fungicide. It has been shown to inhibit the growth of Fusarium verticillioides, a fungus that causes wilt disease in plants. The compound is stereoselective and inhibits the growth of the fungus by inhibiting carbon metabolism at the level of pantolactone synthesis. The bacterial strain used in this study was Pantoea agglomerans, which was found on leaves and roots of six different plant species. (R)-2-Phenylpropylamide also showed antibacterial activity against Pantoea agglomerans and other bacteria. This compound had no significant effect on plant height, leaf area, or total root length. The metabolites were not detected in soil samples after two months, suggesting that (R)-2-phenylpropylamide may not have long-term effects on soil quality.</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 1,2,5-trimethyl-1H-pyrrole-3-carboxylate is a benzenoid compound that can be synthesized from methyl acetoacetate and potassium hydroxide. The yield of the reaction is about 65%. Methyl 1,2,5-trimethyl-1H-pyrrole-3-carboxylate can be used in organic synthesis as an intermediate for other chemicals. This compound undergoes photolysis and has been observed to produce dimethylbenzene and rearrangements such as cyanohydrin formation. The tautomeric form of this compound is hydroxymethylfurfuraldehyde. This compound can also undergo hydrogenolysis with methanolic potassium hydroxide to produce two products: methyl furan carboxylate and methylamine hydrochloride.</p>

<p>1,4-Dimethyl 2-amino-3-methylbenzene-1,4-dicarboxylate (DMAD) is a benzenoid that can be synthesized from 1,4-dimethylbenzene and formaldehyde in the presence of potassium t-butoxide and potassium hydroxide. DMAD is a precursor to other compounds that are used in the production of nylon and polyurethane. The reaction involves two steps: first, the formaldehyde molecule reacts with the dimethyl group on the benzene ring to produce a methylene bridge between two carbon atoms. This intermediate product then reacts with another molecule of formaldehyde or methylene chloride to create an amide bond between the two carbon atoms. DMAD is also an excellent reducing agent and yields hydrogen gas when heated with sodium or potassium cyanide.</p>

<p>2,5-Diiodobenzoic acid is a molecule that has been shown to have anti-cancer properties. It was found to inhibit the growth of malignant glioma cells in vitro and in vivo. The mechanism by which 2,5-diiodobenzoic acid inhibits the growth of these cells is not clear, but it may be due to its ability to change the permeability of the cell membrane or alter the function of proteins such as G proteins. This molecule has also been shown to bind with high affinity to cell nuclei, suggesting that it may be an effective imaging agent for use in diagnosis.</p>

<p>6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-one is a pyrrole with a planar conformation. It has hydrogen bonds to the carbonyl group and two benzenes. The molecule is centrosymmetric and has a dihedral angle of 180°. 6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-one crystallizes in the orthorhombic system. The unit cell dimensions are a=8.05 Å b=8.05 Å c=7.04 Å α=β=γ=90°</p>

<p>3,5-Dinitrobenzaldehyde is an experimental herbicide that has been shown to be effective in the control of weeds. 3,5-Dinitrobenzaldehyde is a protonated electrophilic species that reacts with a variety of electron-rich aromatic compounds by nucleophilic attack at the ortho position. The reaction with benzene, for example, yields phenyl trifluoride and benzenesulfonic acid. This molecule also reacts with chloride to form chlorobenzene and dinitrobenzene. 3,5-Dinitrobenzaldehyde has kinetic properties that are dependent on frequency and layeredness as well as kinetic and dihedral angles. It is also a catalytic reagent that undergoes rapid reaction at room temperature.</p>

<p>2-(4-Methylbenzenesulfonyl)cyclohexan-1-one is a peptide that is used as a research tool. It has been shown to act as an activator of ion channels and to bind to antibodies. 2-(4-Methylbenzenesulfonyl)cyclohexan-1-one can be used in the study of protein interactions and receptor ligand interactions. This product is available in both powder form and as an acetate salt.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>