Building Blocks

<p>2-Cyclohexylidene-2-fluoroacetic acid is a geometrically constrained molecule that has been synthesized and characterized by X-ray crystallography. The compound adopts three conformations, each of which is related to the other two by a rotation of the cyclohexane ring around the central fluoroacetate group.</p>

<p>2-Amino-2-phenylacetamide is a model compound that has been used to study enzyme catalysis. It is an amide with a hydroxylamine group and an aromatic ring. 2-Amino-2-phenylacetamide inhibits the replication of DNA by binding to the protein polymerase, which blocks the transfer of amino acids from the tRNA molecule to the growing strand of DNA. This leads to apoptosis in cells that are susceptible to this type of inhibition. The synthesis of 2-Amino-2-phenylacetamide can be achieved through two methods: nitration of phenylacetic acid and oxidation of benzoic acid with nitric acid. Hydrochloric acid is required for both methods, as well as zinc chloride for the nitration method.<br>2-Amino-2-phenylacetamide is also known as succinoyl.</p>

<p>2-Fluoro-2,3-dihydro-1H-inden-1-one is an enolate salt that has been shown to be effective as a ligand for palladium complexes. The compound is used in the photochemical production of cycloalkanones from allyl alcohols and ketones. 2-Fluoro-2,3-dihydro-1H-inden-1-one has also been used in the synthesis of chiral phosphine ligands. This chemical can be synthesized by reacting potassium phosphate with triflates in the presence of carbonyl compounds. It is also produced when uv irradiation interacts with enolates.</p>

<p>Pteridin-2-amine is a calibration standard that is used to measure the covalent binding of metal ions to protein. It has been shown to have kidney toxicity and can cause liver damage. Pteridin-2-amine can be oxidized by O2 or NO3-, forming oxidation products containing nitrogen atoms, which are detected using voltammetry. The product has a high affinity for neopterin, a metabolic product that is released from eosinophils and mast cells in response to inflammatory stimuli. Pteridin-2-amine can inhibit the enzyme aldehyde oxidase and the activity of an enzyme called catalase, which helps protect cells from oxidative stress. This product has also been shown to form chromatographic peaks with oxygen atoms and sodium hydrogen when mixed with water.</p>

<p>5-Phenyl-3,4-dihydro-2H-pyrrole is a heterocyclic compound that is used in the synthesis of other chemicals. It can be positioned with a variety of functional groups and undergoes aromatisation by the cytochrome P450 enzyme system. 5-Phenyl-3,4-dihydro-2H-pyrrole reacts with perchlorates to form heterocycles such as pyrrolidine and activated pyrrole, which are used in supramolecular chemistry. 5PDP has been shown to react with haloalkanes to form bicyclic heterocycles such as 1,3,5-trioxane.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methoxy-N,N-dimethylaniline is a glycol ether that is used in active antiretroviral therapy. It is an effective contraceptive and has been shown to be safe for use in women. It has been shown to inhibit the polymerase chain reaction (PCR) of HIV-1 and HIV-2, as well as the DNA polymerases of hepatitis B virus and herpes simplex virus type 2. The drug does not affect the function of biological samples such as vaginal cells or semen, but does prevent water vapor from reaching them. 4-Methoxy-N,N-dimethylaniline also inhibits prostaglandin synthesis by binding to cyclooxygenase enzymes. This drug can cause stomach upset and nausea when taken orally, but these side effects are less pronounced when it is administered intravenously.</p>

<p>2-Bromo-4-(chloromethyl)-1-methoxybenzene is a formaldehyde releaser that is used in the production of chloroacetamide. It is also used as an intermediate in organic chemistry, where it is acrylonitrile and chloride alkylation. The bromine atom in 2-bromo-4-(chloromethyl)-1-methoxybenzene can react to release formaldehyde, which may be toxic to humans. Formaldehyde exposure has been linked to cancer and other diseases.</p>

<p>4-(Propan-2-yloxy)benzene-1-thiol is a chemical that inhibits the enzyme acetyl-coa carboxylase. It is used in medicinal chemistry to create inhibitors of this enzyme. 4-(Propan-2-yloxy)benzene-1-thiol has been found to be selective for the inhibition of acetyl-coa carboxylase and not other enzymes such as malonyl coenzyme A carboxykinase. The high throughput screening of this compound has led to the discovery of new inhibitors with potential therapeutic benefits.</p>

<p>Versatile small molecule scaffold</p>

<p>Dimethyl cyclopropane-1,2-dicarboxylate (DMCPD) is a racemic antiviral agent that inhibits the synthesis of viral nucleic acids and proteins. It was developed as an intermediate for the production of allylstannanes and substituted cyclobutyls. DMCPD has been shown to inhibit the replication of influenza A virus in calf-thymus cells.</p>

<p>Versatile small molecule scaffold</p>

<p>5,5-Diethyl-1,3-oxazinane-2,4-dione is a water soluble plant growth regulator that belongs to the chemical class of hydroxylated dioximes. It has been shown to have biological properties in plants and is used as a soil wetting agent, but not as an herbicide. 5,5-Diethyl-1,3-oxazinane-2,4-dione has been shown to be highly resistant to microbial infection and have biocompatible properties. This compound was also found to be nonirritant in vitro and can be used as a sample preparation tool for kinetic studies. The compound is also useful for the detection of radiation in fatty acids.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Dichloroquinoline is a nitrated nitrogen heterocycle, which has been orientated to the para position. It is a precursor to a variety of other compounds, including 5,8-dichloroquinoline and 3-chloro-5,8-dichloroquinoline.</p>

<p>7,8-Dichloroquinoline is a chlorinated quinoline that can be used as a marker for the identification of lactobacillus acidophilus. It has been shown to be an effective agent against l. acidophilus and other lactobacilli in vitro. The effect of 7,8-dichloroquinoline on the growth of lactobacillus species was studied using a nutrient agar medium containing potassium phosphate and calcium carbonate as nutrients. The results showed that 7,8-dichloroquinoline inhibited the growth of all strains tested except Lactobacillus pentosus and Lactobacillus brevis.</p>

<p>3-Phenyl-2-oxazolidinone is a potent antibacterial agent. It has been shown to be active against a wide range of Gram-positive and Gram-negative bacteria, including Enterococcus faecalis, Staphylococcus aureus, Mycobacterium avium complex and Escherichia coli. 3-Phenyl-2-oxazolidinone has also been shown to inhibit the growth of Mycobacterium tuberculosis in culture. The mechanism of action is not yet fully understood but may involve inhibition of cell wall synthesis or protein synthesis. 3-Phenyl-2-oxazolidinone also exhibits antiviral activity against human immunodeficiency virus type 1 (HIV) and herpes simplex virus type 2 (HSV).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methyl-1-phenylbutan-2-ol is a benzene derivative that is used in the formulation of perfumes, as well as other products. It is safe to use and has no known side effects. 3-Methyl-1-phenylbutan-2-ol is a fragrance ingredient that belongs to the class of aromatic alcohols. This compound has been shown to have toxicologic and dermatologic properties, although it does not cause irritation or sensitization.<br>3-Methyl-1-phenylbutan-2-ol contains a benzene ring with an alcohol group. The benzene ring has two methyl groups at positions 1 and 2.</p>

<p>2-Hydroxy-3-phenylpropanamide is a fatty acid that has been shown to have radical scavenging activity. It is an omega-3 fatty acid, which means it has the first double bond at the third carbon from the methyl end of the molecule. 2-Hydroxy-3-phenylpropanamide also has a phenolic group, which is a type of chemical group with one or more hydroxyl (-OH) groups attached to an aromatic hydrocarbon ring. This compound may be selective for substrate, as it does not react with carboxylic acids or amides. 2-Hydoxy-3-phenylpropanamide's unsaturated aliphatic chain makes it susceptible to oxidation and can lead to the formation of carboxylic acids and aldehydes, which are reactive molecules.</p>

<p>2-Hydroxy-1-phenylpentane is a mandelonitrile with an alcohol group. It is a cytotoxic compound that can induce apoptosis in cancer cells. 2-Hydroxy-1-phenylpentane has been shown to inhibit the growth of MDA-MB-231 breast cancer cells and induce apoptosis. In addition, this compound also induces apoptosis in rat liver cells and human fibroblasts. This compound induces apoptosis by inhibiting the phosphatidylinositol 3 kinase (PI3K)/Akt pathways. 2-Hydroxy-1-phenylpentane also inhibits cell growth through a clonogenic assay in which it was found to be toxic to mouse embryonic stem cells at concentrations greater than or equal to 50 μM, but not at concentrations less than 10 μM. The toxicity of 2-Hydroxy-1-phenylpentane may be due to its ability to bind with DNA and</p>

<p>3-(3-fluorophenyl)prop-2-ynoic acid is an organic compound that is used as a reagent in organic synthesis. It is activated with strong Lewis acids such as aluminum chloride and boron trifluoride etherate to yield the terminal alkynes. The terminal alkynes can be converted to carboxylic acids by carboxylation. 3-(3-Fluorophenyl)prop-2-ynoic acid has been shown to catalyze the reaction in which propiolic acid reacts with butyllithium, yielding methylene chloride and 1,1,1-trichloropropanol. 3-(3-Fluorophenyl)prop-2-ynoic acid also has a mononuclear structure and can be diffracted by x-rays.</p>

<p>1-Fluoro-3-phenoxypropan-2-ol is a chiral epoxide that is used as a reagent in organic synthesis. It reacts with styrene to form an enantiomerically pure styrene oxide. 1-Fluoro-3-phenoxypropan-2-ol also has the ability to react with epoxides, chlorohydrins, and chloride to form cyclohexene oxide and fluorine oxide, respectively. The stereochemistry of these reactions can be manipulated by changing the solvent or by using an enantioselective catalyst.</p>

<p>²-(Benzylamino)propionitrile is a synthetic organic compound that is used in the synthesis of catalytic amines and aziridinium salts. It is an intermediate for the production of amines and aziridinium salts, which are compounds with a wide range of applications. ²-(Benzylamino)propionitrile also has the ability to be used as a ligand in metal-catalyzed reactions, such as hydrochloric acid catalyzed reactions. This chemical can be reused several times and is stable at temperatures from 0 to 150 ˚C.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Oxo-1,3-dihydro-2-benzofuran-1-carboxylic acid is a cyclic compound with a molecular weight of 174.19. It is a white crystalline solid with a melting point of 164°C and can be found in isopropyl alcohol. 3-Oxo-1,3-dihydro-2-benzofuran-1-carboxylic acid is used as an intermediate for the synthesis of coatings, which are applied to surfaces to protect them from corrosion or other chemical attack. The reaction time and solvent must be considered when working with this compound.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Cyano-1-phenylpyrazole is a nitrile that can be chloromethylated to form 4-chloro-1-phenylpyrazole. It is a herbicide that inhibits plant growth by inhibiting photosynthesis. The type of reaction can be halogenation, alkoxycarbonylation, or chloromethylation. This compound hydrolyzes at a relatively fast rate in water and reacts with other compounds to form derivatives of the original molecule. 4-Cyano-1-phenylpyrazole binds to the c3 and c4 positions on the cycloalkane ring and also binds to alkenes with an oxygen atom at the end of the chain (such as allyl alcohol). The compound has been used in both pharmaceuticals and agricultural products. 4-Cyano-1-phenylpyrazole is toxic to plants and animals because it inhibits cell membrane function.</p>

<p>Versatile small molecule scaffold</p>

<p>1-(3-Nitrophenyl)-2-thiourea is a small molecule inhibitor of the transporter protein SLC5A8, which transports nitrates from the blood to the kidneys. 1-(3-Nitrophenyl)-2-thiourea inhibits this transporter in a systemically active fashion and selectively targets renal epithelial cells. This analog has been shown to be effective against some inherited disorders associated with mutations in SLC5A8. 1-(3-Nitrophenyl)-2-thiourea is believed to inhibit transport by binding to an allosteric site on SLC5A8, but its precise mechanism of action remains unclear.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>