Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methyl-5-nitro-1H-indole is a potent inhibitor of rifampicin, which is an antibiotic used to treat tuberculosis. 3-Methyl-5-nitro-1H-indole inhibits the growth of bacteria by binding to the 50S ribosomal subunit. It does not show any bactericidal activity in vitro and has been found to be ineffective in mice with chronic infections. 3-Methyl-5-nitro-1H-indole binds to the 50S ribosomal subunit and prevents the formation of antibiotic–ribosome complexes that are needed for bacterial protein synthesis. This drug also has pharmacokinetic properties that have been optimized for oral administration in humans. 3methyl 5 nitro 1H indole targets enzymes involved in DNA replication and transcription, such as bacterial gyrase, dna topoisomerase, and RNA polymerase.</p>

<p>2,5-Dioxo-2,5-dihydro-1H-pyrrole is a compound that belongs to the group of heterocyclic compounds. It is an amide derivative of 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1yl)phenylacetic acid. 2,5-Dioxo-2,5-dihydro-1H pyrrole has been shown to have high radiation resistance and can be used for the production of polyimide film and plastics. This compound also has thermogravimetric properties that make it suitable for use as a heat transfer fluid in industrial furnaces. 2,5 Dioxo -2,5 dihydro -1H pyrrole has nitrogen atoms at both ends of the molecule that are reactive with amino groups on other molecules. The terminal amino groups on 2, 5 dioxo</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride is a chloride that has been shown to have nitro and carbonyl groups. It has been used in animal studies for the treatment of infectious diseases such as gram-negative bacteria, herpes virus, or glyceraldehyde phosphate dehydrogenase. 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride inhibits glycolytic enzyme and cyanoalkyl amines.<br>END&gt;</p>

<p>Versatile small molecule scaffold</p>

<p>1-Phenyl-2-(pyridin-2-yl)ethan-1-amine is a diagnostic agent that can be used to detect the presence of c1-6 alkyl groups in the body. It is a prodrug that is hydrolyzed by esterases to form pyridinium ion, which has been shown to bind to nucleotides and inhibit c1-6 alkoxy and arylalkylamine receptors. The inhibition of these receptors leads to neuroprotective effects in animal models. 1-Phenyl-2-(pyridin-2-yl)ethanamine also has been shown to have beneficial effects on depression, neurodegenerative diseases, and polymorphisms.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(1,4-Diazepan-1-yl)ethanone is an imidazopyridine that acts as a competitive inhibitor of tyrosine kinases, which are enzymes important for the transmission of signals in the central nervous system and other tissues. This drug has been shown to have a high degree of selectivity for receptor tyrosine kinases and inhibit the activity of IGF-1 receptor at low concentrations, with no significant effects on other receptors such as dopamine or serotonin. 1-(1,4-Diazepan-1-yl)ethanone has also been shown to be an effective inhibitor of channel proteins that mediate neurotransmitter release.</p>

<p>(1,4-Diazepan-1-yl)(furan-2-yl)methanone is an inhibitor of protein interactions. It binds to the active site of the enzyme and blocks access by the substrate. This inhibitor can be used as a research tool in cell biology, as well as in pharmacology and peptide chemistry. It is also an activator of Ligand and a ligand for Receptor. (1,4-Diazepan-1-yl)(furan-2-yl)methanone has shown no toxicity to cells at concentrations up to 10 mM.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Yuzurine is a natural product that has been shown to be a potent inhibitor of the enzyme methionine adenosyltransferase. This drug has been synthesized from 4-(bromomethyl)-5-hydrofuran-2-one and propargyl bromide in the presence of a rhodium catalyst. Yuzurine is an optically active compound, which means that it can exist as two different enantiomers. The enantioselective synthesis of yuzurine was achieved by using a chiral dieckmann condensation reaction with ruthenium as a catalyst.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Methyl 2-methyl-6-nitro-benzoate (MMNB) is a small molecule that has been shown to inhibit the growth of human cancers. MMNB inhibits cell growth by inhibiting the activity of lysine in hCT-116 cells. It also binds to the active site of HCT-116 and A549 lung cancer cells, blocking DNA synthesis and tumor formation. MMNB can be used as a therapeutic agent for cancer prevention or treatment. The inhibition of cell growth is reversible, with MMNB being excreted from the body within 24 hours after its administration.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>