Building Blocks

2-(4-Benzoylphenoxy)acetic acid is a phenoxy compound that can be used as an antinociceptive agent. It has been shown to inhibit the pain response in mice by binding to the peripheral cannabinoid receptor CB2 and blocking intracellular calcium channels, thereby inhibiting the release of pro-inflammatory molecules. 2-(4-Benzoylphenoxy)acetic acid also inhibits the activity of two enzymes involved in carbonic acid production and glucose metabolism, which may provide protection against metabolic disorders. Computational methods have been used to model the molecular structure of 2-(4-benzoylphenoxy)acetic acid, which are then compared with experimental data on hydrogen bonding interactions between dihedral angles and intramolecular hydrogen bonds.

Versatile small molecule scaffold

2-Amino-5-chloro-3-nitrobenzoic acid is a synthetic compound that has been shown to have topoisomerase activity. It binds to the DNA of cancer cells and inhibits the expression of certain genes, which inhibits cell proliferation. 2-Amino-5-chloro-3-nitrobenzoic acid also interacts with the drug transport protein p-glycoprotein, inhibiting its function and leading to multidrug resistance in cancer cells. This drug has been shown to be cytotoxic for lung carcinoma cells.

5-Cyclohexyl-5-methylimidazolidine-2,4-dione is a ligand that binds to the receptor and activates it. It is used in research as a tool for studying ion channels, peptides, and protein interactions. 5-Cyclohexyl-5-methylimidazolidine-2,4-dione has been shown to inhibit the binding of an antibody to its antigen.

Versatile small molecule scaffold

Versatile small molecule scaffold

Bis(2-phenylethyl)amine hydrochloride (BPEA) is a compound that has been shown to have neuroprotective effects in animal models of Alzheimer's disease. This compound has been found to inhibit the formation of reactive oxygen species, which are responsible for neuronal cell death. BPEA also inhibits the enzyme amine oxidase, which is responsible for the breakdown of neurotransmitters and may be involved in the development of Alzheimer's disease and other neurodegenerative diseases. BPEA has been shown to be effective in preventing and treating symptoms of Alzheimer's disease in an experimental model. Dipropylamine (DPEA), a known inhibitor of amine oxidase, was tested with BPEA and found to have synergistic effects. DPBA was not able to prevent or treat symptoms when given alone.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

This is a pyridine compound that is used in the nitration of aromatic compounds. It can be synthesized by reaction of 2-aminopyridine with nitric acid and sulfuric acid, followed by filtration and recrystallization. The experimental procedure for this compound is not currently available.

Versatile small molecule scaffold

2-Amino-3,4,6-trichlorophenol is a versatile compound that has various applications in different fields. It is commonly used in chromatographic analysis as a reference standard and as a reagent in organic synthesis. This compound is also found naturally in plants such as monoterpenoids, isoflavones, pyrazoles, alkaloids, and chalcones. Additionally, it has been identified as a component of certain research chemicals.

Ethyl 3-cyano-3-phenylpyruvate is a chemical compound that is used as an antiviral agent. It has been shown in vitro to inhibit influenza virus and depression. Ethyl 3-cyano-3-phenylpyruvate is synthesized by the alkylation of furyl with phenyl group, followed by the reduction of the tetronic acid formed. The antiviral activity of ethyl 3-cyano-3-phenylpyruvate was analyzed by assessing the ability to inhibit viral replication and production of new viruses. The sodium salt form of this compound is used in foodstuff as a preservative.

Sodium 5-sulphoisophthalate is a chemical compound that is the monosodium salt of sulfonated 5-sulphoisophthalic acid. It is an important raw material in the production of polycarboxylic acids, which are used as intermediates in the production of nylon and polyester. The reaction vessel for the production of sodium 5-sulfoisophthalate is usually a stainless steel pressure reactor. Sodium carbonate and sulfur trioxide react at high temperatures to produce sodium 5-sulfoisophthalate and hydrogen sulfide. The product can be purified by fractional distillation, or it can be reacted with ammonia to form ammonium sulfite, which can then be used as a fertilizer. Sodium 5-sulfoisophthalate has been shown to have fluorescence properties and can serve as a probe for hydrogen bonding between molecules.

(2S)-2-Acetamido-3-hydroxy-N-methylpropanamide is a compound that belongs to the class of phosphopeptides. It is synthesized by reacting an N-acetylcysteamine with methylamine in the presence of sodium bicarbonate. This compound has shown to have antihypertensive and vasodilatory effects, as well as the ability to inhibit platelet aggregation.

Tert-butyl 2-azidoacetate is a synthetic chemical that is used to synthesize azides. It reacts with ethyl diazoacetate to produce tert-butyl azide and tert-butanol. This reaction can be used to synthesize the azide functional group in a single step, which is more efficient than the traditional two-step process. Tert-butyl 2-azidoacetate has been shown to have antibacterial activity against hl-60 cells, an immortalized promyelocytic leukemia cell line. The antibacterial effect of tert-butyl 2-azidoacetate may be due to its ability to react with amino groups on proteins and phosphonates on DNA, which are important for bacterial growth and replication.

2-Hydroxy-4,6-dimethylbenzoic acid (HMBA) is a tumor treatment drug that can be used in combination with other drugs. HMBA inhibits proton pumps and the synthesis of DNA, RNA, and protein. The proton pump inhibitors are used to treat acid reflux disease, ulcers, and gastroesophageal reflux disease. HMBA has been shown to significantly inhibit tumor growth in animal studies. This drug also has anti-inflammatory effects and may be useful for treating arthritis.

Acetaminophen, also known as paracetamol, is a widely used drug for pain relief and fever reduction. It is metabolized by the liver, mainly through the cytochrome P450 pathway. The cytochrome P450 pathway produces reactive intermediates that can cause oxidative stress and DNA damage. Acetaminophen has been shown to be toxic to rat primary hepatocytes in vitro at concentrations of 40-160 μM after 24 hours. Acetaminophen has also been shown to be mutagenic and carcinogenic in rats at doses of 5000 mg/kg/day, which is equivalent to a human dose of 160 mg/kg/day or higher. These effects are due to acetaminophen’s metabolic activation by reactive oxygen species (ROS) and its ability to induce cytotoxicity and oxidative stress in cells.