Building Blocks

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>CRT0066101 is a protein kinase inhibitor that has shown to be effective in inhibiting the growth of cancer cells. CRT0066101 inhibits the activity of HER2+ breast cancer cells by binding to and blocking the function of protein kinases, which are enzymes that regulate cell growth. The mechanism of action for CRT0066101 is not fully understood but it may be due to its ability to inhibit protein synthesis or block the activation of transcription factors. CRT0066101 also blocks the proliferation of HER2+ breast cancer cells in an experimental model and has shown efficacy against other types of cancers including pancreatic and colorectal cancers. This drug is currently undergoing clinical trials for use as an anti-cancer treatment.</p>

<p>Versatile small molecule scaffold</p>

<p>dBET57 is a molecule that targets the ubiquitin-proteasome system (UPS) by linking the ubiquitin protein to the proteasome. It has been shown that dBET57 binds to bromodomains and modulates gene expression in cancer cells, inhibiting cell growth. The e3 ubiquitin ligase can also be inhibited by dBET57 through binding to its target site. This leads to lysis of cancer cells and induces autophagy, which is an important cancer therapy.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Monoethyl Pimelate is a synthetic aliphatic hydrocarbon that is a hdac inhibitor. HDAC inhibitors are used in the treatment of cancer, as they inhibit the activity of histone deacetylases and so lead to an increase in acetylation of histones. This process increases the expression of genes that promote cell death and inhibits the expression of genes that promote cell growth. Monoethyl Pimelate has been shown to have anti-carcinogenic effects on prostate carcinoma cells in vitro. In addition, this compound has been shown to be beneficial for the diagnosis of prostate cancer, as it can be used as a diagnostic agent. It also increases cellular energy metabolism through its ability to activate fatty acid oxidation in mitochondria.</p>

<p>Versatile small molecule scaffold</p>

<p>1-(Quinolin-3-yl)ethanone is a synthetic quinazolinone that is used in the synthesis of other compounds. It is a sterically hindered compound that is mediated by hydrogen bonding, which allows it to act as an amine or nucleophile and react with carbonyl groups. 1-(Quinolin-3-yl)ethanone can also be methylated with formic acid to give a monohydric compound that can be reacted with an alkali metal to give a dihedral intermediate. This intermediate can then react with nitrogen nucleophiles to give products such as quinazolinones.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methylbut-3-yn-2-yl carbamate is a synthetic compound that belongs to the group of thiosemicarbazides. It has been shown to possess a broad spectrum of activity against Gram-positive and Gram-negative bacteria, including Mycobacterium tuberculosis. The drug is hydrolyzed by esterases or glucuronidases, oxidized by cytochrome P450 enzymes, reduced by glutathione reductase, or conjugated with glucuronic acid.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,3-Dihydro-1,4-benzodioxine-2-carboxamide is a dopamine receptor agonist that has been shown to bind to the 5-HT2A and D3 receptors. It has been used as an antipsychotic agent in the treatment of schizophrenia, bipolar disorder, and depression. The pharmacophore for this drug is based on the profile of dopamine D3 receptor agonists. The hybridization profiles of 2,3-dihydro-1,4-benzodioxine-2-carboxamide with 5HT2AR (5HT2A receptor) and 5HT2CR (5HT2C receptor) have been determined using NMR spectroscopy.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>4,5-Diphenyl-oxazol-2-ylamine is a heterocycle that belongs to the pyridine class of heterocycles. It has been synthesized by a two step process starting with 2,6-dichloropyridine. The first step is a nucleophilic substitution reaction involving the chloro group and an amine group at C3 position of the pyridine ring. The second step involves an electrophilic aromatic substitution reaction with 4,5-diphenyloxazole to form the desired product. This compound has been shown to be more reactive than other heterocycles due to its electron withdrawing groups.</p>

Versatile small molecule scaffold

<p>1-Amino-3,3-dimethyl-butan-2-one hydrochloride is a carboxamide that inhibits the cyclin-dependent kinases (CDKs) and is used to treat immune diseases. It has been shown to inhibit the production of nitric oxide by inhibiting the enzyme nitric oxide synthase. 1-Amino-3,3-dimethyl-butan-2-one hydrochloride also inhibits the activity of kinases that are important for cell division and proliferation. This drug was also found to have anti cancer properties as it prevents cells from dividing. The drug binds to an aromatic ring system in proteins and blocks the activity of enzymes that are responsible for protein synthesis.</p>

2-Amino-3-methyl-1-phenylbutan-1-one hydrochloride is an optical isomer that has been shown to be a potent muscle relaxant. It has been shown to have a high degree of efficacy in clinical studies for the treatment of spasticity from multiple sclerosis and spinal cord injury. This drug also has anti-inflammatory properties and is used in medicines for the treatment of pain. 2-Amino-3-methyl-1-phenylbutan-1-one hydrochloride binds to glutamic acid, an amino acid found in proteins, and inhibits its ability to bind with glutamine, which leads to a decrease in the production of glutamic acid.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>1-bromo-4-(prop-2-yn-1-yloxy)benzene is a chemical reagent that has been used for the preparation of trichosporon. This compound is highly active and can be used as an additive in copper catalysts. It has also been shown to have antifungal activity against filamentous fungi, such as Trichophyton and Rhizopus. The molecular structure of 1-bromo-4-(prop-2-yn-1-yloxy)benzene was determined using XRD data from a Cu(111) surface.</p>