Building Blocks

<p>1-Bromo-4-methoxy-2,5-dimethylbenzene is a synthetic compound that stabilizes the nf-e2-related factor. This compound has shown to be effective in reducing pulmonary fibrosis in mice and may have potential as a therapeutic agent for cancer. 1-Bromo-4-methoxy-2,5-dimethylbenzene interacts with Keap1, which leads to luminescence properties and autophagy of lung cancer cells. It also induces proteasomal degradation of proteins and is resistant to antibiotics. 1-Bromo-4-methoxy-2,5-dimethylbenzene has been shown to inhibit Mycobacterium tuberculosis growth by preventing cell wall synthesis.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>2-(1-Methyl-1H-1,3-benzodiazol-2-yl)-1-phenylethanone is a phenylhydrazone that can initiate acylation reactions. The reaction of 2-(1-methyl-1H-1,3-benzodiazol-2-yl)-1phenylethanone with an acylating agent leads to an acylated product. This compound has been shown to undergo recyclization with sodium methoxide in methanol to form the corresponding hydroxamic acid.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,4-Dimethyl-2-hydroxybenzoic acid is a pseudocumene derivative that is an energy source for pseudomonads. This compound is the most abundant of the 3,4-dimethylbenzoic acid isomers. It can be found in a number of techniques such as nuclear magnetic resonance and mass spectroscopy. The various 3,4-dimethylbenzoic acid isomers have been identified by their characteristic spectral data and magnetic resonance signals. The 3,4-dimethylbenzoic acid isomers are differentiated from each other by their different magnetic properties, which depend on their structure.</p>

<p>Versatile small molecule scaffold</p>

2-Iodo-6-methoxypyrazine is a chemical compound that belongs to the group of aromatic compounds. It is used as an intermediate in the production of other chemicals. 2-Iodo-6-methoxypyrazine has been found to inhibit the growth of microorganisms and can be used in the production of antibiotics, antihistamines, and antioxidants. The biosynthesis of 2-iodo-6-methoxypyrazine is carried out by chondromyces crocatus (a type of fungus). This process starts with the conversion of pyruvic acid into acetaldehyde by aldehyde decarboxylase. Acetaldehyde then reacts with methyl iodide to form 2-iodoacetaldehyde. Next, this intermediate reacts with methoxyacetone phosphate, leading to methyl pyruvate and finally 2-iodo-6-methoxypyrazine.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>5-Chloro-8-nitroisoquinoline is a cytotoxic agent that belongs to the class of pyridopyrimidines. It is an amidation product of 8-nitroisoquinoline and 5-chloroacetaldehyde, which is prepared by condensation of nitrostyrene with acetone. 5-Chloro-8-nitroisoquinoline has anticancer activity against human cancer cells in vitro and in vivo. The mechanism of action is multidrug resistance, mediated by overexpression of P glycoprotein. This drug also inhibits the reductive activation of hypoxia inducible factor (HIF) alpha, which leads to its cytotoxicity.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>N-(3-Cyanophenyl)acetamide is a hydrogen-bonding molecule that has been detected in the gas phase. It has also been observed to interact with water, forming hydrogen bonding interactions and solvatochromism. The equilibrium of N-(3-cyanophenyl)acetamide can be shifted by changing the solvent conditions and pH. This molecule has three conformations when it is in the gaseous phase, including a planar conformation. In addition, N-(3-cyanophenyl)acetamide can be used as a probe for determining hydrogen bonding interactions and conformations due to its ability to form hydrogen bonds with other molecules.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

2,2-dimethylhex-5-enoic acid is an organic compound that belongs to the class of aldehydes. It can be synthesized by decarboxylation of 2,2-dimethylhexane. The selectivity is high and the functional groups are already present in the molecule. This reaction is a decarboxylative annulation and it requires a catalyst. This synthesis has been shown in chemistry textbooks as an example of a functional group transformation.

Versatile small molecule scaffold

<p>Spiro[1,3-dioxolane-2,8'-pentacyclo[5.4.0.0²,⁶.0³,¹⁰.0⁵,⁹]undecan]-11'-one is an organic compound that has a ketal group in its structure. It is also a hydrogen bond donor and a reductive coupling agent with properties of intramolecular hydrogen bonding and dimerization. The intramolecular hydrogen can be found in the ring of the spiro[1,3-dioxolane-2,8'-pentacyclo[5.4.0.0²,⁶.0³,¹⁰.0⁵,⁹]undecan]-11'-one that is bonded to the ketal group as well as on the benzene ring on the other side of the molecule when it is bound to another spiro[1</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>