Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Benzyl-4-(1H-pyrrol-1-yl)piperidine is a chemical compound that has been shown to be effective in the treatment of autoimmune diseases and cancer. It also has anti-inflammatory properties, and can be used to treat eye disorders such as retinitis pigmentosa. 1-Benzyl-4-(1H-pyrrol-1-yl)piperidine binds to bromodomain proteins, which are found on the surface of cells and control gene transcription. This binding inhibits protein synthesis, leading to cell death. The chemical compound has been shown to have a glycosidic bond with an unknown carbohydrate structure.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Monastrol is a natural compound that has been shown to induce apoptosis in cancer cells. It binds to the mitochondrial membrane, thereby causing mitochondrial membrane depolarization and inhibiting ATP production. Monastrol also inhibits axonal growth by blocking tubulin polymerization, which is required for axon elongation. This drug is being investigated as a potential treatment for skin cancers and leishmaniasis. Monastrol has been shown to inhibit the proliferation of carcinoma cell lines and to reduce metastasis in animals models. Preparative high pressure liquid chromatography (HPLC) has been used to isolate monastrol from Anhydrous Sodium Monastearate (ASM).

Versatile small molecule scaffold

<p>5-Phenyl-1,3-oxazole-4-carbonitrile (5PO) is a reagent that can be used for the coupling of potassium with an anion. The radical mechanism of this reaction has been shown to use copper as a catalyst. 5PO is also useful for the preparation of cyanide salts from cyanides, such as potassium cyanide, ferricyanide, and hydrocyanic acid. 5PO is typically prepared in situ by coupling an alkyl halide with a phenylhydrazine.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>3-(4-Bromophenyl)cyclobutanone is a lactonization product of 4-bromophenylacetic acid. Lactonization is the process of converting an ester into a cyclic lactone. 3-(4-Bromophenyl)cyclobutanone is synthesized from 4-bromophenylacetic acid in yields of up to 97%. The substrate concentration has been shown to have a significant effect on the yield of 3-(4-bromophenyl)cyclobutanone, and the maximum yield was achieved at a concentration of 5 g/L. This compound can be prepared by oxidation of cyclobutanone using peroxides, lipases, or chemoenzymatic methods. 3-(4-Bromophenyl)cyclobutanone belongs to the family of aliphatic ketones and has an aromatic ring with two substituents (a phenyl group and a bromine atom).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

4,4,4-Trifluoro-2-hydroxybutanoic acid is an alcohol that is used in the synthesis of benzaldehydes. This compound can be extracted from a variety of sources, including natural sources such as plants and animals. 4,4,4-Trifluoro-2-hydroxybutanoic acid has been shown to react with butyllithium to form a mixture of 2:1:1 (R:S:R) diastereomers. The reaction is carried out under conditions that favor the formation of the desired product. This process produces high yields and allows for chiral products to be synthesized in high optical purity.

<p>Versatile small molecule scaffold</p>

2,3-Dihydro-1-benzofuran-7-ol is a peroxide that can be used as an alternative to hydrogen peroxide in wastewater treatment. The compound is chemically stable and has a low toxicity to mammals. It has been shown to be effective in the removal of carbofuran and other pesticides from water. The removal of these chemicals is achieved by oxidation at the 2,3-dihydro-1-benzofuran-7-ol molecule's oxygen atom, which removes the pesticide's hydrogen atom. The reaction time for this process depends on the concentration of pesticide in the water sample. 2,3-Dihydro-1-benzofuran-7-ol reacts with ionic contaminants such as heavy metals and nitrates via catalytic effect with mineralization of these ions. This process can be used for the remediation of polluted soil and water due to its high efficiency and low cost.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-(1H-Pyrazol-4-yl)pyridine is a chemical compound that has been shown to have anti-cancer activity. It has been found to inhibit the growth of ovarian cancer cells and is being studied as a potential treatment for other cancers. 3-(1H-Pyrazol-4-yl)pyridine binds to acetylcholine receptors in cancer cells, leading to cell apoptosis. It also inhibits the synthesis of DNA and RNA, which are necessary for cell division. 3-(1H-Pyrazol-4-yl)pyridine is an excellent catalyst and can be used in multiphase reactions such as cyanosilylation, where it reacts with sulfur dioxide (SO2) to produce polysulfide (polysulfur).</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Benzyl 2-amino-3-hydroxypropanoate hydrochloride is a chiral molecule with a S configuration. It is the racemic mixture of two enantiomers, which are mirror images of each other. The compound has been shown to inhibit bacterial growth by binding to the 50S ribosomal subunit and inhibiting protein synthesis. This drug also inhibits the formation of siderophores and pseudobactin, which are involved in iron uptake. Benzyl 2-amino-3-hydroxypropanoate hydrochloride also has an anti-inflammatory effect and may be used as an adjuvant therapy for tuberculosis or cancer chemotherapy.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold