Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Benzenesulfonyl-piperidine-4-carboxylic acid ethyl ester is an inhibitor of acetylcholinesterase. It is a white solid that can be synthesized in two steps from commercially available starting materials. Inhibition of this enzyme leads to the accumulation of acetylcholine, which causes increased stimulation of nicotinic and muscarinic receptors. This drug has been shown to have IC50 values that are similar to those of the reference inhibitor donepezil. 1-Benzenesulfonyl-piperidine-4-carboxylic acid ethyl ester also interacts with sulfonyl chlorides, butyrylcholinesterase, and other proteins in a manner similar to donepezil. The molecular docking studies suggest that this compound binds competitively with the active site of acetylcholinesterase.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

6,8-Dimethoxyquinoline is a quinoline derivative that has been used to synthesize a number of other drugs. It has shown activity against cancer cells in vitro and in vivo and has been shown to have an anticholinergic effect on the central nervous system. 6,8-Dimethoxyquinoline also inhibits bacterial growth and is active against Gram-positive bacteria such as Enterococcus faecalis, Staphylococcus aureus, Streptococcus pyogenes, and Bacillus subtilis. This compound binds to the enzyme carbonic anhydrase II with high affinity. The binding of 6,8-dimethoxyquinoline with carbonic anhydrase II prevents the conversion of CO2 into carbonic acid, which may lead to cell death by inhibiting respiration.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Prop-2-en-1-yl benzoic acid is an alkenoic, organometallic compound that is a metabolite of 2-bromopropane. It can be obtained from the bromolactonization of tetrahydrofuran with lithium aluminum hydride followed by allylic oxidation with chromium oxide and sodium hydroxide. Prop-2-en-1-yl benzoic acid has been shown to inhibit the enzyme acetylcholinesterase, which leads to increased levels of acetylcholine in the brain. This leads to increased activity on nicotinic receptors and improved cognition. This compound has also been shown to be a ligand for donepezil, which is an inhibitor of cholinesterases. Donepezil is used as a treatment for Alzheimer's disease and other forms of dementia, but it does not cross the blood brain barrier. In this case, prop-2-en-1

2-Bromo-2-cyclohexen-1-ol is an organic compound that belongs to the group of chlorides, iodides, and yields. Mechanistic studies have shown that this compound reacts by nucleophilic attack at a reactive site that contains halides. The chloride ion is a terminal alkyne and has been shown to be reactive with 2-bromo-2-cyclohexen-1-ol. The indole nitrogen in 2-bromo-2-cyclohexenol has been shown to undergo nucleophilic substitution with an aryl chloride substrate. This reaction has been shown to be reversible by adding base.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Hydroxy-4-propoxybenzaldehyde is a metabolically stable inhibitor of the enzyme, phenylalanine 4-hydroxylase. 3HPA inhibits the production of phenolic compounds and reduces the risk of cancer. It has been shown to be potently active against human leukemia cells in vitro, but less active against other cell lines. 3HPA is also selective for tumor cells, which may be due to its ability to inhibit DNA synthesis by preventing the formation of n-substituted benzylamino compounds. 3HPA stabilizes DNA and RNA synthesis, which may help prevent tumor growth.

2-(Pyridin-2-yl)pyrimidin-4-amine (PPPA) is an antimicrobial agent that is used in the treatment of bacterial infections. It binds to the chloride ion in the cell wall and prevents the formation of a functional pore, causing leakage of cellular contents. PPPA reacts with cyanamide to form 2-(pyridin-2-yl)pyrimidin-4(1H)-one (PPPOH), which is more reactive than PPPA. The reactivity of PPPOH causes damage to the cell's cytoplasmic membrane, leading to cell death. PPPA also reacts with nitro, alkynyl, and alkylaminoalkyl groups, as well as carboxy, cyano, and alkenyl groups on proteins and amino acids. PPPA hydrolyzes phenoxy and cyclohexane rings found in some antibiotics such as tetracycline.

Versatile small molecule scaffold