Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Tert-Butyl N-benzylcarbamate is a synthetic compound that is being developed for the treatment of cancer. It is an analog of carmustine, a drug used for the treatment of brain tumors, and has been shown to be effective against cell lines in vitro. Tert-Butyl N-benzylcarbamate binds to DNA and inhibits protein synthesis, leading to cancer cell death. The drug also inhibits the growth of cancer cells by inhibiting chloride channels and blocking the influx of hydrogen chloride into cells. Tert-Butyl N-benzylcarbamate has not been tested in humans yet, but it has shown promising results in animal models.</p>

<p>Versatile small molecule scaffold</p>

<p>Cycloheptanecarboxamide is a cellular amide that is used in the study of β-amino acids. Cycloheptanecarboxamide is a prodrug that is converted to cycloheptylamine, which has been shown to be an inhibitor of proliferation and a potent inhibitor of inflammatory diseases. Cycloheptylamine also inhibits the production of aliphatic hydrocarbons and mineralocorticoids, as well as the activation of mineralocorticoid receptors. It has been shown to be an organic solution that can be used to generate tartrate-resistant acid potassium ions (TRAP).</p>

<p>Dicyclohexylmethanol is a trifunctional compound that contains a hydroxyl group, and can be used as a hydrogen bond donor or acceptor. The chemical structure of dicyclohexylmethanol can be seen in the figure below. Dicyclohexylmethanol has been used for sample preparation for hydrogen chloride gas. It has also been used to determine the concentration of blood ethanol levels and to measure blood pH in humans. Dicyclohexylmethanol is an important reactant in asymmetric synthesis reactions due to its ability to form hydrogen bonds with both reactants.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Dichloroacetic acid methyl ester (DCA) is a metabolic disorder agent that belongs to the group of detergent compositions. It is an important intermediate in the synthesis of sodium salts and hiv infection inhibitors, such as hydrochloric acid and covalent linkages. DCA reacts with water molecules to form hydroxyl groups and then reacts with metal carbonyls to produce anhydrous sodium. This product also reacts with fatty acids to produce alcohol residue and can be used in the reaction solution. The product has a pyrazole ring with a hydroxyl group at one end and an alcohol residue at the other end.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-3,3,3-trifluoro-1-propene is a chemical compound that has been synthesized in an asymmetric reaction. The reactant is bromopropane and the product is 2,2,2-trifluoropropene. The methylene group on the propene molecule is activated by the nucleophilic attack of a fluoride ion from hydrogen fluoride to form a cavity with a highly strained bond. The kinetic study of this reaction revealed that the activation energy for the reaction is 42 kJ/mol. Palladium-catalyzed coupling reactions are catalyzed by palladium and require nonpolar solvents such as toluene or dichloromethane. This type of reaction has been shown to be exothermic with an isolated yield of 1%.</p>

<p>2-Cyano-5-fluorophenol is an organic compound that is used as a precursor to medicines and other chemicals. It reacts with calcium hydroxide in water to form 2-cyano-5-hydroxyfluorobenzene, which can be hydrolyzed to form 2-cyano-5-chlorofluorobenzene. This compound can also react with sodium hydroxide to produce sodium cyanate, which can be hydrolyzed to form sodium chloride and hydrogen cyanide gas. The alkali metal ions are needed for this reaction, which is why the product should not be exposed to water or moisture. 2-Cyano-5-fluorophenol has been shown to have liquid crystal properties and is used in the production of certain types of polymers. 2Cyano-5Fluorophenol crystals are also used in some medicines such as acetaminophen (paracetamol).</p>

<p>Versatile small molecule scaffold</p>

<p>Tri-GalNAc-NHS ester is a multivalent molecule composed of three GalNAc cluster arms. It is a protein degrader and a ligand of the asialoglycoprotein receptor (ASGPR) used for the development of targeted therapies for liver diseases. The GalNAc arms enable high-affinity binding to the ASGPR on hepatocyte surfaces. The crucial functional group, N-hydroxysuccinimide (NHS) ester, is known for its ease of conjugation with various biomolecules possessing amine (NH2) groups. This biocompatible reaction strategy allows the design and development of targeted conjugates such as drug-GalNAc conjugates, siRNA delivery vehicles, or probes for ASGPR imaging in the liver.</p>