Building Blocks

N-benzylsulfamide is a synthetic cannabinoid derivative that is activated by hydrochloric acid in the stomach. It is an agonist of the cannabinoid receptor, which is found in the brain and nervous system. N-benzylsulfamide has been shown to produce muscle relaxation by increasing potassium efflux from muscle cells and decreasing calcium influx, leading to decreased contractions. N-benzylsulfamide has also been shown to have anti-inflammatory effects. It inhibits prostaglandin synthesis by inhibiting cyclooxygenase activity, thus reducing inflammation. The molecule also binds to benzodiazepine receptors and can be used as a treatment for seizures or convulsions.

4-Hydrazinothieno[2,3-d]pyrimidine is an anti-cancer drug that is activated by xylene. It is used in the treatment of bowel disease and cancer. 4-Hydrazinothieno[2,3-d]pyrimidine has been shown to have antibacterial properties against Gram-positive bacteria and may be effective as a topical agent for skin infections. This drug also has platelet activating properties, which are mediated through the p2y12 receptor. This receptor is involved in inflammatory bowel disease, as well as other tissues such as the brain and heart. 4-Hydrazinothieno[2,3-d]pyrimidine may be useful in treating cancer because it inhibits the production of TNF-α (tumour necrosis factor alpha) which leads to tumor growth inhibition.

(-)-Menthone is a plant metabolite that is found in peppermint and other mint oils. It can be synthesized by the action of caffeic acid esterase on menthol, which is also present in peppermint oil. (-)-Menthone has been shown to inhibit the enzyme activities of human pathogens such as Salmonella typhimurium, Escherichia coli, and Shigella sonnei. (-)-Menthone also has genotoxic activity and has been shown to cause chromosome breaks in human lymphocytes. The reaction mechanism of (-)-menthone involves an intramolecular hydrogen transfer from one carbon atom to another. X-ray diffraction data from (-)-menthone crystals show a phase transition temperature of approximately -5°C for the molecule.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Chromoionophore xi (CI) is a monoclonal antibody that binds to the CCR5 receptor on the surface of HIV-1. The binding of CI to the receptor inhibits HIV-1 entry into CD4+ cells, leading to a decrease in viral load. CI has an effective dose of 0.8 μg/mL and inhibits HIV-1 infection by 50% at 1 μg/mL. Chromoionophore xi has been shown to be effective in inhibiting HIV-1 infection in vitro and in vivo in mice.

Versatile small molecule scaffold

Versatile small molecule scaffold