Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-(2,3-Dihydro-1,4-benzodioxine-6-sulfonyl)piperazine hydrochloride is an experimental drug that belongs to the group of pharmacological agents. It is a piperazine derivative with potent antagonistic effects against opioid receptors. It has been shown to have synergic effects when used with other drugs. Structural analysis revealed the presence of nitrogen atoms in the molecule and crystallinity was confirmed by x-ray diffraction data. The solubility of this compound in human serum is low. 1-(2,3-Dihydro-1,4-benzodioxine-6-sulfonyl)piperazine hydrochloride has been observed to inhibit the production of cytokines such as interleukin and tumor necrosis factor alpha (TNFα).

<p>2-Aminomethyl-3-phenylpropionic acid is a chemical compound that is used as a catalyst in the hydrocyanation of alkyne to produce unsaturated compounds. It is also an amino acid that contains an α-amino group and a carboxylic acid. 2-Aminomethyl-3-phenylpropionic acid has been shown to be effective for producing yields of up to 99% in nickel-based catalysts for the hydrocyanation of alkyne. This compound is also inexpensive, nonhazardous, and stable at high temperatures.</p>

1-Bromo-1-ethoxycyclopropane is a structural modification of the cyclopropanone ring. It has been shown to be resistant to many bacteria, such as Pseudomonas aeruginosa and Escherichia coli, and also inhibits the growth of fungi. 1-Bromo-1-ethoxycyclopropane has been shown to act as an antibacterial agent by inhibiting the synthesis of proteins in bacteria and can work synergistically with aminoglycosides. 1-Bromo-1-ethoxycyclopropane may have a role in nature as it has been found to inhibit the growth of malonate oxidase from organisms such as Acinetobacter calcoaceticus.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

N-(2-bromo-6-nitrophenyl)acetamide is a bidentate ligand that was synthesized as an acetylated derivative of diazonium salt. It binds to transition metal ions such as copper and nickel, which are important for the catalytic activity of many enzymes. The binding of N-(2-bromo-6-nitrophenyl)acetamide to the active site of these enzymes inhibits the reaction by forming a complex with the substrate, thereby preventing it from reacting with the enzyme. In addition, this ligand has been shown to have strong absorption in the visible range, which is useful for detection of transitions in organic molecules. Nitro groups can be introduced through nitration reactions or by adding nitrobenzene to N-(2-bromo-6-nitrophenyl)acetamide. One advantage of N-(2-bromo-6-nitrophenyl)acetamide over other

Versatile small molecule scaffold

<p>4-Aminopyrimidine-2-carbonitrile is an organic compound that is structurally related to pyrimidine derivatives. It is a drug candidate for the treatment of tuberculosis (TB) and other multidrug resistant bacteria. 4-Aminopyrimidine-2-carbonitrile has been shown to be more potent than formamide and triethyl orthoformate, but less potent than aminopyrazole. The mechanism of action of 4-aminopyrimidine-2-carbonitrile is not well understood, but it may involve an epoxide intermediate that generates reactive oxygen species, which causes necrosis in the bacterial cell. The drug also exhibits some activity against tumour necrosis factor alpha (TNFα).</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>