Building Blocks

<p>1-(4-Chlorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid is a pyrazole with anticancer activity. It inhibits the growth of cancer cells by inhibiting the protein synthesis and DNA replication in tumour cells. <br>This active form binds to DNA polymerase, thereby preventing transcription and replication. This compound also has antiviral activity against herpes virus and vaccinia virus, and is effective against some tumour cell lines. 1-(4-Chlorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid has been shown to be active against leukemia cells, lymphoma cells, neuroblastoma cells, breast cancer cells, colon cancer cells, prostate cancer cells, pancreatic cancer cells, hepatocellular carcinoma cells, lung cancer cell lines and other types of human cancers. The spectrum of this compound includes various types of human cancers (e.g.,</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>4-Morpholino-piperidine 2HCl is a heterocyclic organic compound that is used as an intermediate in the synthesis of pharmaceuticals. It has been shown to be structurally similar to benzyl, and can be identified by GC/MS. 4-Morpholino-piperidine 2HCl is also known as ethyl isonipecotate, dihydrochloride, or hydrogenation. 4-Morpholino-piperidine 2HCl is a white solid or crystalline powder that has a melting point of 71°C and a boiling point of 235°C.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Ethyl 2,3-dihydro-1-benzofuran-3-carboxylate is a salicylaldehyde that is synthesized by the cyclooxygenase pathway. It has anti-inflammatory properties and is used as an active ingredient in nonsteroidal anti-inflammatory drugs. It has been shown to inhibit cyclooxygenase, which is one of the enzymes that converts arachidonic acid to prostaglandin H2. This drug also inhibits thromboxane A2 synthesis and platelet aggregation, preventing blood clotting. Ethyl 2,3-dihydro-1-benzofuran-3-carboxylate is metabolized by acylation or benzoylation reactions with the enzyme benzofuran synthase. The efficiency of this drug can be optimized by using a trifluoromethanesulfonate catalyst.

<p>2-Chloro-5-fluoropyrazine is a chemical compound that is used as an intermediate in the synthesis of other compounds. It is a synthetic intermediate that can be prepared by the amination of chloral with trifluoromethoxybenzene. The coupling reaction between 2-chloro-5-fluoropyrazine and various electrophiles has been shown to be efficient. This molecule can also be synthesized by reacting pyrazines with chlorine gas in the presence of catalysts such as palladium or nickel. 2-Chloro-5-fluoropyrazine has been used in Buchwald-Hartwig aminations, which are a scalable method for the synthesis of heterocycles.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>4,5-Dichloropicolinamide is a cancer drug that belongs to the class of drugs known as alkylating agents. It has been shown to disrupt the DNA of cancer cells and inhibit their growth. 4,5-Dichloropicolinamide also inhibits fetal development in pregnant women by increasing the levels of certain hormones in maternal serum.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>