Building Blocks

<p>Dimebon is a drug that binds to dopamine receptors (D2 and D3) and inhibits locomotor activity in rats. It also has been found to be effective in the treatment of cancer-induced cachexia, as well as bowel disease. Dimebon is a hydrogenated form of rac-(4aR,9bS)-2,8-dimethyl-1H,2H,3H,4H,4aH,5H,9bh-pyrido[4,3-b]indole. The drug was originally synthesized in the Soviet Union for use as an antidepressant but was never marketed because it caused severe side effects such as tardive dyskinesia. Dimebon has been shown to cause neuronal death through inhibition of the growth factor BDNF and its receptor activity. It also blocks dopamine release from nerve cells in the striatum. Dimebon is water soluble and can be taken orally or injected intravenously.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Bromo-1H-indene is the structural modification of naphthalene. This compound is a benzannulation product that can be systematically obtained through the addition of methoxy groups to the naphthalene ring. 5-Bromo-1H-indene has been shown to have a role in solar cells, as it can act as an electron donor and acceptor. This molecule also has a mechanistic role in transport, as it can bind to metal carbene complexes and form a stable complex with them. 5-Bromo-1H-indene has been used in the synthesis of biomolecules such as arene and fluorine, which are important for the treatment of cancer.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methyl-8-hydroxyquinoline (3MQ) is a chemical compound that has been shown to be an inhibitor of the enzyme cyclen. 3MQ binds to the active site of cyclen and blocks the binding of calcium ions, preventing the formation of calcium complexes with cyclen. This inhibition leads to a decrease in cyclen activity and an increase in the synthesis of protein. 3MQ has also been shown to be potent inhibitor against chloride ion currents through voltammetry experiments. It was found that its redox potential is very low, which suggests that it can be used as a probe for electron transfer reactions in cells. The photophysical properties of 3MQ have also been studied and it was found that this molecule absorbs light at wavelengths between 400–600 nm, which may lead to its use as a photosensitizer or photoantagonist for photodynamic therapy.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>6-Hydroxyquinoline-2-carboxylic acid is a drug that has been shown to inhibit phospholipidosis, which is the accumulation of phospholipids in cells. It also inhibits naphthalene-induced hyperphosphorylation and histamine release from mast cells. 6-Hydroxyquinoline-2-carboxylic acid is an acceptor for the pharmacophore model and has been validated by molecular properties. The optimization process for this compound was monitored and validated. This lead compound is being considered as a potential therapeutic agent for the treatment of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and lupus erythematosus.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Nitrothiophene-3-carbaldehyde (NTAC) is a tripodal that has been shown to be able to form aggregations with other molecules. It has been used in solar cells as a semiconductor material and can be used as a ligand for optical or x-ray sensors. NTAC also has the ability to absorb light and can be used as a dye in dye-sensitized solar cells. The electron affinity of NTAC is low, making it an effective electron acceptor for photocatalytic reactions. This compound is also useful for particle size measurements using microscopy techniques.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>