Acids and Synthetic Reagents

Applications (S)-5,6-Dehydro Pregabalin is derived from rac 5,6-Dehydro Pregabalin (D230055), which is an impurity of the anti-convulsant, Pregabalin (P704800).
References Dousa, M, et al.: J. Pharmac. Biomed. Anal., 53, 717 (2010);

Applications α-L-Idopyranose pentaacetate is used in the synthesis of mucopolysaccharides as antagonists agents.
References Hopwood., et al.: Clinica Chem. Acta, 123, 241 (1982), Ogamo., et al.: Carbohydr. Res., 105 (1982),

Applications Dihydrokainic acid is an EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake.
References Grunewald, M., et al.: J. Biol. Chem., 275, 9684 (2000); Shimamoto, K., et al.: Mol. Pharmacol., 53, 195 (1998);

Applications A Nicotinic acid (N429250) analogue used as a growth factor in Erwinia amylovora growth (pear and apple blossoms).
References Davis, A., et al.: Planta, 205, 305 (1998), Valls, F., et al.: J. Agric. Food Chem., 48, 3392 (2000), Gardener, M., et al.: J. Chem. Ecol., 2001, 27, 2545 (2001),

Applications Bevirimat is a HIV-1 maturation inhibitor, targetting the Gag CA-SP1 cleavage site. HIV Inhibitor.
References Coric, P. et al.: Eur. J. Med. Chem., 62, 453 (2013); Waki, K. et al.: PLoS Path., 8, e1002997 (2012);

Stability Unstable in Solution, Moisture Sensitive, Hygroscopic
Applications (S)-(+)-2-Amino-4-bromobutyric Acid Hydrobromide is a building block used in stereoselective preparation of phosphinic acid phosphapeptide analogs of glutamyl-γ-glutamate as potent inhibitors of folylpolyglutamate synthetase. Also used in the synthesis of isoindoline carbamate and acylsulfonamide containing macrocyclic peptidomimetics as inhibitors of HCV NS3/4A protease.
References Bartley, D., et al.: J. Org. Chem., 70, 6757 (2005); Jiang, Y., et al.: J. Med. Chem., 57, 1753 (2014);

Applications N-Carbethoxyphthalimide is used in the synthetic preparation of a novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors.
References Hua, Z., et al.: J. Med. Chem., 56, 10003 (2013);

Applications Sodium Tetrachloroaurate(III) Dihydrate, is an essential chemical compound used in chemical synthesis as gold catalyst.

Applications 4-(2,3-Dimethoxyphenyl)butanoic acid is a butyrate analogue with effects on apoptosis, proliferation and histone deacetylase (HDAC) activity in HT-29 colorectal cancer cells.
References Scheppach, W., et al.: Eur. J. Cancer, 31A, 1077 (1995), Wu, J., et al.: J. Lipid Res., 46, 1944 (2005), Kiefer, J., et al.: Br. J. Nutr., 96, 803 (2006),

Applications 4-Bromobenzotrifluoride is an aromatic compound that is used as a reagent to synthesize Bergenin (B318650), a compound that originates in Mallotus japonicus that exhibits hepatoprotective and antioxidant effects. 4-Bromobenzotrifluoride is also used as a reagent to prepare (±)-Preclamol, a partial dopamine D2 agonist that is used to treat Parkinson’s disease.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lim, H., et al.: Pharmacology, 63, 71 (2001); Parkan, K., et al.: Chem. Eur. J., 20, 4414 (2014); Pirtosek, Z., et al.: Clin. Neuro., 16, 550 (1993); Takahashi, H., et al.: Bioorg. Med. Chem., 11, 1781 (2003); Vasdev, N., et al.: Synapse, 60, 314 (2006)

Stability Moisture Sensitive
Applications 2-Acetamido-5-nitrophenylboronic acid, pinacol ester

Applications 18α-Glycyrrhetinic Acid rapidly and reversibly blocks gap junction intercellular communication (GJIC).
References Guo, Y., et. al.: Am. J. Phys.: 276, L1018 (1999)

Stability Photosensitive
Applications It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML).

Applications AMG 337 is a potent and selective inhibitor of mesencymal epethelial transition factor (MET factor) which has been implicated in several cancers.
References Boezio, A. et al.: J. Med. Chem., 59, 2326 (2016);

Applications SP 2509 reduces the effect of the LSD1 binding to CoREST, resulting in increased methylation of H3K4 and driving increased expression of p21, p27 and CCAAT/enhancer binding protein α in acute myeloid leukemia cells. Anti-leukemia agent.
References Sorna, V. et al.: J. Med. Chem., 56, 9496 (2013); Fiskus, W. et al.: Leukemia, 11, 2155 (2014);